Division of Population Genetics • Saitou Group

Genome evolution of organisms with special reference to human


Research Summary

We study genome evolution of organisms mainly through computer analyses. We are particularly interested in evolution of modern humans and primate and mammalian evolution toward human. Research interests are (1) genome data analysis of modern humans with special reference to those in Japanese Archipelago including ancient DNA, (2) lineagespecific evolutionary changes at different levels of organism groups such as Hominidae, primates, mammals, and vertebrates, (3) development of methods useful for evolutionary genomic studies.

Conservation levels of noncoding sequences identical only among Hominidae (human, chimpanzee, gorilla, and orangutan) and their flanking regions. From Saber et al. (2016).


Kanzawa-Kiriyama, H., Kryukov, K., Jinam, T.A., Hosomichi, K., Saso, A., Suwa, G., Ueda, S., Yoneda, M., Tajima, A., Shinoda, K., Inoue I., and Saitou, N. (2017). A partial nuclear genome of the Jomons who lived 3000 years ago in Fukushima, Japan. J Hum Genet 62, 213-221.

Saber, M.M., Babarinde, I.A., Hettiarachchi, N., and Saitou, N. (2016). Emergence and evolution of Hominidae-specific coding and noncoding genomic sequences. Genome Biol Evol 8, 2076-2092.

Babarinde, I.A., and Saitou, N. (2016). Genomic locations of conserved noncoding sequences and their proximal protein-coding genes in mammalian expression dynamics. Mol Biol Evol 33, 1807-1817.