Developmental Biology II (2010) Syllabus

Course objectives: Development can be viewed as an integral of molecular and cell biological events, and also is a process though which evolutionary changes in form is generated Through discussing how the principles and concepts of developmental biology developed and what kind of new challenges they generate, students are expected to nurture their framework in which they conduct their own work in various disciplines. Prerequisites: Familiarity with basic concepts of Molecular and Cell Biology is recommended.
Contents: This course will introduce basic principles and concepts of that direct developmental phenomena. Various developmental events, such as cell fate determination, cell differentiation, morphogenesis and animal behavior will be analyzed in light of gene expression, cell-cell interaction, intracellular signaling and evolution. Classes will be run by critical reading of the primary literature and discussion. It is essential that you have read the papers before coming to the class. Please download the papers from the links provided below.This course will be conducted in English.
Time: 13:30 – 15:10 on Fridays Place: National Institute of Genetics, B202 (Library 2nd floor seminar room)
Cource organizer: Yasushi HIROMI Participating faculty
Schedule:
Date Lecturers Topic and paper
2010/10/29 Yasushi HIROMI Ichiro HIRATANI Developmental transition in early embryos Newport J, Kirschner M. A major developmental transition in early Xenopus embryos I, II Cell 30: 675-686 and 687-696, 1982
2010/11/5 Kazuo EMOTO (*) Yasushi HIROMI Novel cellular mechanisms in neuronal plasticity Grubb MS, Burrone J Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability Nature 465: 1070-1074, 2010 Kuba H, Oichi Y, Ohmori H Presynaptic activity regulates Na1 channel distribution at the axon initial segment. Nature 465: 1075-1078, 2010
2010/11/12 Saori MIYAZAKI Yasushi HIROMI Proliferation of plant germline Kim HJ, Oh SA, Brownfield L, Hong SH, Ryu H, Hwang I, Twell D, Nam HG Control of plant germline proliferation by SCF(FBL17) degradation of cell cycle inhibitors. Nature 455:1134-1137, 2008
2010/11/19 Takashi HAYASHI Yasushi HIROMI Differential adhesion as a mechanism of morphogenesis Steinberg MS Reconstruction of tissues by dissociated cells. Science 141:401-408, 1963 Steinberg MS, Takeichi M. Experimental specification of cell sorting, tissue spreading, and specific spatial patterning by quantitative differences in cadherin expression. Proc Natl Acad Sci USA 91:206-209, 1994
2010/11/26 Minori SHINYA Yasushi HIROMI Link between speciation and sex chromosome Kitano J, Ross JA, Mori S, Kume M, Jones FC, Chan YF, Absher DM, Grimwood J, Schmutz J, Myers RM, Kingsley DM, Peichel CL. A role for a neo-sex chromosome in stickleback speciation. Nature 461: 1079-83, 2009
2011/1/7 Koichi KAWAKAMI Yasushi HIROMI FGF signaling in brain patterning Cholfin JA, Rubenstein JL. Patterning of frontal cortex subdivisions by Fgf17. Proc Natl Acad Sci USA 104:7652-7657, 2007 Storm EE, Garel S, Borello U, Hebert JM, Martinez S, McConnell SK, Martin GR, Rubenstein JL. Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers. Development 133:1831-1844, 2006
2011/1/14 Takahiko KAWASAKI Yasushi HIROMI Role of neural activity in the neural development Borodinsky LN, Root CM, Cronin JA, Sann SB, Gu X, Spitzer NC Activity-dependent homeostatic specification of transmitter expression in embryonic neurons. Nature 429: 523-530, 2004
2011/1/21 Takuji IWASATO Yasushi HIROMI Ocular dominance column development in the primary visual cortex Crowley JC and Katz LC Development of ocular dominance columns in the absence of retinal input. Nat Neurosci. 2:1125-1130, 1999 Crowley JC and Katz LC Early development of ocular dominance columns. Science 290:1321-1324, 2000
The reading list and the course schedule is tentative and is subject to change. (*) special guest lecturer
Appropriate grade level and Eligible Departments: (x) 1, (x) 2, (x) 3, (x) 4, (x) 5: ( ) School of Life Science， (x) All Departments，( ) Other
Grades: To obtain credit one must attend five or more classes (of total of eight classes) . Grades (Pass/Fail) will be determined based on the extent of participation in class. Notes: Developmental Biology II, III, and IV will all be done in the same style, critical reading of the primary literature, covering various topics in developmental biology. Students must read the assigned paper before coming to the class. Active participation in discussion is essential. There will be no overlap in the teaching material that will be used in Developmental Biology II, III, and IV. Taking any one of the three courses will likely give you an idea what development is about. If you wish to specialize in the field of Developmental Biology, we recommend taking all three courses. Reading lists for the previous years: 2009 2008 2007 2006 For students who are unable to appreciate scientific discussions in English, the course organizer will offer a one-hour discussion session in Japanese for each class. To schedule a discussion session, read the assigned paper and send an email to the course organizer, listing three issues/problems that you would like to discuss. The deadline for scheduling an appointment is 13:30 of the day of the class (Friday). Indicate the time of the day that does not suit you, during the period of Monday following the class to Friday of the next week.
Participating faculty:
name email (xxxx[at]lab.nig.ac.jp) phone (055-981-xxxx) office
Tatsumi HIRATA tathirat 6721 C518
Yasushi HIROMI yhiromi 6767 C415
Takuji IWASATO tiwasato 6773 C408
Akatsuki KIMURA akkimura 5854 A321
Koichi KAWAKAMI kokawaka 6740 C115
Tsuyoshi KOIDE tkoide 5843 X209
Yumiko SAGA ysaga 6829 R221
Noriyoshi SAKAI nosakai 5848 S109
Toshihiko SHIROISHI tshirois 6818 R115
Ryu UEDA rueda 6823 R205
 
last updated 101211

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