Course description:
Various developmental events, such as cell fate determination, cell differentiation, morphogenesis and animal behavior will be analyzed in light of gene expression, cell-cell interaction, intracellular signaling and evolution. Classes will be run by critical reading of the primary literature and discussion.
科目の概要:
細胞運命決定、細胞分化、形態形成や個体の行動制御等の個体発生の様々な現象を、遺伝子発現調節、細胞間相互作用、細胞内情報伝達等の分子機構や進化の視点から議論し、論文講読とディスカッションを通した演習を行う。（講義）
Course purpose:
Development can be viewed as an integral of molecular and cell biological events, and also is a process though which evolutionary changes in form is generated. Through discussing how the principles and concepts of developmental biology developed and what kind of new challenges they generate, students are expected to nurture their framework in which they conduct their own work in various disciplines.
科目の目的:
発生現象は分子細胞学的現象が「積分」されたものと捉えることができます。また、発生過程は形態変化の進化がおこる場所でもあります。この授業では、発生生物学の様々な原理や概念がどのようにして生まれ、どのような新たな問題を生み出すかを議論することを通じ、各自が自分の分野での研究の枠組みを作るのに役立ててもらうことを目指しています。
|
Contents:
This course will introduce basic principles and concepts of that direct developmental phenomena. Various developmental events, such as cell fate determination, cell differentiation, morphogenesis and animal behavior will be analyzed in light of gene expression, cell-cell interaction, intracellular signaling and evolution. Classes will be run by critical reading of the primary literature and discussion. Please download the paper from links below and take a look at it in advance. It is not necessary to have completely understood the paper before coming to class. This course will be conducted in English. For questions and comments in Japanese, lecturers will provide simultaneous translation service to English.
授業内容:
授業計画：この授業では個体発生を指令する様々な基本原理や概念をとりあげます。細胞運命決定、細胞分化、形態変化、行動等のイベントについて、遺伝子発現、細胞間相互作用、シグナル伝達や進化等の観点から分析します。この授業は「原著論文を読んで議論する」という形式で行います。前もって論文を以下のリンクからダウンロードし、目を通しておいてください。完全に理解する必要はありません。この授業は英語で行いますが、日本語での質問やコメントに対しては講師が同時通訳サービスを提供します。 |
Time: 13:30 - 15:10 on Mondays 月曜13:30-15:10
Place: National Institute of Genetics, B301 (Library 3rd floor seminar room) 遺伝研B301(図書館３階）
People in other departments/institutions can participate in this class using the remote lecture system.
他専攻の方は遠隔講義システムで受講できます．
|
| Cource organizer: SAWA Hitoshi 澤 斉 |
Participating faculty 担当教員リスト |
Schedule:
| Date |
Lecturers |
Topic and paper |
2023/11/ 6
|
NEGISHI Takefumi
根岸 剛文 |
Mitotic spindle orientation in development
Orientation of Asymmetric Stem Cell Division by the APC Tumor Suppressor and Centrosome (PDF)
Yukiko M. Yamashita, D. Leanne Jones, and Margaret T. Fuller
Science 301 (5639), . DOI: 10.1126/science.1087795
Before you read this paper
|
2023/11/13
|
SATO Yutaka
佐藤 豊 |
Stem cell homeostasis
Control of Arabidopsis shoot stem cell homeostasis by two antagonistic CLE peptide signalling pathways (PDF)
Jenia Schlegel, Gregoire Denay, Rene Wink, Karine Gustavo Pinto, Yvonne Stahl, Julia Schmid, Patrick Blumke, Rudiger GW Simon
eLife 2021;10:e70934. DOI
Before you read this paper
|
2023/11/27
|
MIYOSHI Keita
三好 啓太 |
Maternal-to-zygotic transition
SMAUG Is a Major Regulator of Maternal mRNA Destabilization in Drosophila and Its Translation Is Activated by the PAN GU Kinase (PDF)
Wael Tadros 1 5, Aaron L. Goldman 2 5, Tomas Babak 1 3, Fiona Menzies 1 5, Leah Vardy 6 7, Terry Orr-Weaver 6 7, Timothy R. Hughes 1 2 3, J. Timothy Westwood 8, Craig A. Smibert 4, Howard D. Lipshitz
DOI 10.1016/j.devcel.2006.10.005
Before you read this paper
|
2023/12/ 4
|
HIRATA Tatsumi
平田 たつみ |
Species-specific pace of development
A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals (PDF)
Jorge Lazaro, Maria Costanzo, Marina Sanaki-Matsumiya, Charles Girardot, Masafumi Hayashi, Katsuhiko Hayashi, Sebastian Diecke, Thomas B Hildebrandt, Giovanna Lazzari, Jun Wu, Stoyan Petkov, Rudiger Behr, Vikas Trivedi, Mitsuhiro Matsuda, Miki Ebisuya
Cell Stem Cell 2023; 30:938-949. doi: 10.1016/j.stem.2023.05.014.
Before you read this paper
|
2023/12/11
|
KAWAGUCHI Akane
川口 茜 |
Regeneration
Cells keep a memory of their tissue origin during axolotl limb regeneration (PDF)
Martin Kragl, Dunja Knapp, Eugen Nacu, Shahryar Khattak, Malcolm Maden, Hans Henning Epperlein & Elly M. Tanaka
doi:10.1038/nature08152
Advancements to the axolotl model for regeneration and aging. (PDF)
Warren A. Vieira,1 Kaylee M. Wells,1 and Catherine D. McCusker
doi:10.1159/000504294
Understanding positional cues in salamander limb regeneration: implications for optimizing cell-based regenerative therapies (PDF)
Catherine D. McCusker* and David M. Gardiner
doi:10.1242/dmm.013359
Before you read this paper
|
| 2023/12/18 |
KIMURA Akatsuki
木村 暁
|
Accuracy of morphogen gradient
Probing the Limits to Positional Information (PDF)
Gregor, T., Tank, D. W., Wieschaus, E. F. & Bialek, W.
Cell 130, 153-164 (2007).
Before you read this paper
|
2024/ 1/15
|
NONOMURA Ken-ichi
野々村 賢一 |
Evolution of reproductive systems
DNA methylation restrains transposons from adopting a chromatin signature permissive for meiotic recombination (PDF)
Natasha Zamudio, Joan Barau, Aurélie Teissandier, Marius Walter, Maté Borsos, Nicolas Servant, and Déborah Bourc'his
doi: 10.1101/gad.257840.114
Before you read this paper
|
2024/ 1/22
|
KUBO Fumi
久保 郁 |
Topographic map formation
Genetic Analysis of Ephrin-A2 and Ephrin-A5 Shows Their Requirement in Multiple Aspects of Retinocollicular Mapping (PDF)
Neuron 2000:
Vol. 25, Issue 3, pp. 563-574
D A Feldheim 1 , Y I Kim, A D Bergemann, J Frisen, M Barbacid, J G Flanagan
Before you read this paper
|
The reading list and the course schedule is tentative and is subject to change.
使用する論文は変更される可能性があります． |
Appropriate grade level and Eligible Programs: (x) 1, (x) 2, (x) 3, (x) 4, (x) 5:
(x) All Programs |
Pre-requisites: Familiarity with basic concepts of Molecular and Cell Biology is recommended.
This course will be conducted in English. For questions and comments in Japanese, lecturers will provide simultaneous translation service to English.
履修条件：分子細胞生物学の基礎的知識があるとより楽しめるでしょう。
その他：この授業は英語で行いますが、日本語での質問やコメントに対しては講師が同時通訳サービスを提供します。
|
Grades:
To obtain credit one must attend five or more classes (of total of eight classes). Grades (A, B, C, D) will be determined based on the activity of discussion with lecturer and other students.
単位取得には８セッションのうち５つ以上に出席する必要があります．成績（A,B,C,D）は講師や他の学生との議論への参加の程度によって判定します．
Notes:
Developmental Biology 1, 2 is a discussion-based course involving critical reading of the primary literature. Each year, one of the two courses (Developmental Biology 1 or 2) will be offered, with no overlap in the material used. Taking any one of the two courses will likely give you an idea what development is about. If you wish to specialize in the field of Developmental Biology, we recommend taking all two courses.
発生生物学1, 2は原著論文をネタに議論する形式で行います．毎年2つの科目のどれか（発生生物学1または2）が開講され，これら2科目での使用論文の重複はありません．どの科目を履修しても発生生物学の「味見」はできるでしょう．自分で発生研究を志しているなら2科目全てを聞いてみることをお勧めします．
Reading lists for the previous years:
2022
2021
2020
2019
2018
2017
2016
2015
2014
2013
2012
2011
2010
2009
2008
2007
2006
Other courses in developmental biology
Developmental Biology I (e-learning course, in Japanese)
Developmental Biology (offered in the Department of Basic Biology)
Reproductive Biology (offered in the Department of Basic Biology)
|