Course description :
Various developmental events, such as cell fate determination, cell differentiation, morphogenesis and animal behavior will be analyzed in light of gene expression, cell-cell interaction, intracellular signaling and evolution. Classes will be run by critical reading of the primary literature and discussion.
科目の概要:
細胞運命決定、細胞分化、形態形成や個体の行動制御等の個体発生の様々な現象を、遺伝子発現調節、細胞間相互作用、細胞内情報伝達等の分子機構や進化の視点から議論し、論文講読とディスカッションを通した演習を行う。
Course purpose:
Development can be viewed as an integral of molecular and cell biological
events, and also is a process though which evolutionary changes in form is
generated. Through discussing how the principles and concepts of developmental
biology developed and what kind of new challenges they generate, students are
expected to nurture their framework in which they conduct their own work in
various disciplines.
科目の目的 :
発生現象は分子細胞学的現象が「積分」されたものと捉えることができます．また，発生過程は形態変化の進化がおこる場所でもあります．この授業では，発生生物学の様々な原理や概念がどのようにして生まれ，どのような新たな問題を生み出すかを議論することを通じ，各自が自分の分野での研究の枠組みを作るのに役立ててもらうことを目指しています．
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Contents:
This course will introduce basic principles and concepts of that direct developmental phenomena. Various developmental events, such as cell fate determination, cell differentiation, morphogenesis and animal behavior will be analyzed in light of gene expression, cell-cell interaction, intracellular signaling and evolution.Classes will be run by critical reading of the primary literature and discussion. Please download the paper from links below and take a look at it in advance. It is not necessary to have completely understood the paper before coming to class. This course will be conducted in English. For questions and coments in Japanese, lecturers will provide simultaneous translation service to English.
授業内容:
この授業では個体発生を指令する様々な基本原理や概念をとりあげます．細胞運命決定，細胞分化，形態変化，行動等のイベントについて，遺伝子発現，細胞間相互作用，シグナル伝達や進化等の観点から分析します．この授業は「原著論文を読んで議論する」という形式で行います．前持って論文を以下のリンクからダウンロードし，目を通しておいてください．完全に理解する必要はありません．この授業は英語で行いますが，日本語での質問やコメントに対しては講師が同時通訳サービスを提供します． |
Time: 13:30 - 15:10 on Mondays 月曜13:30-15:10
Place: National Institute of Genetics, B202 (Library 2nd floor seminar room) 遺伝研B202(図書館２階）
This course is also offered as a part of the Integrative Bioscience Education Program.
People in other departments/institutions can participate in this class using the remote lecture system.
この授業は統合生命科学教育プログラムの一部としても履修できます．他専攻の方は遠隔講義システムで受講できます．
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| Cource organizer: Yumiko Saga 相賀 裕美子 |
Participating faculty 担当教員リスト |
Schedule:
| Date |
Lecturers |
Topic and paper |
2016/11/7
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Takuji IWASATO
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Discovery of odorant receptors and development of the olfactory system
A novel multigene family may encode odorant receptors: a molecular basis for odor recognition.
1991 Apr 5;65(1):175-87. Buck L1, Axel R.
Before you read this paper
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2016/11/14
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Hitoshi SAWA |
Cell-cell signaling
Pattern formation during vulval development in C. elegans.
Sternberg PW, Horvitz HR
Cell 44: 761-772, 1986
Before you read this paper |
2016/11/21
|
Katsutoshi TSUDA |
Regulation of organ
initiation in plant
Regulation of phyllotaxis by polar auxin
transport
Didier Reinhardt, Eva-Rachele Pesce, Pia Stieger, Therese Mandel, Kurt Baltensperger, Malcolm Bennett, Jan Traas, Jir˘ı´ Friml, ris Kuhlemeier
Before you read this paper
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2016/11/28
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Yan ZHU |
Matrix elasticity and cell lineage determination
Matrix Elasticity Directs Stem Cell Lineage Specification
Adam J. Engler, Shamik Sen, H. Lee Sweeney, Dennis E. Discher
Before you read this paper |
| 2016/12/ 5 |
Yumiko SAGA |
Temporal coliniality
with Hox genes
Uncoupling time and space in the collinear regulation of Hox genes.
Tschopp P, Tarchini B, Spitz F, Zakany J, Duboule D.
PLoS Genet. 2009 Mar;5(3):e1000398.
参考論文（reference papers)
Gene transpositions in the HoxD complex reveal a hierarchy of regulatory controls.
van der Hoeven F, Zakany J, Duboule D.
Cell. 1996 Jun 28;85(7):1025-35
Breaking Colinearity in the Mouse HoxD Complex
Takashi Kondo and Denis Duboule
Cell, Vol. 97, 407-417, 1999
Before you read this paper |
2016/12/12
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Toshihiko SHIROISHI |
Evolution of cis-regulatory elements
Progressive Loss of Function in a Limb Enhancer during Snake Evolution
Evgeny Z. Kvon, Olga K. Kamneva, Uira´ S. Melo, Iros Barozzi, Marco
Osterwalder, Brandon J. Mannion, Virginie Tissie`res, Catherine S.
Pickle, Ingrid Plajzer-Frick, Elizabeth A. Lee, Momoe Kato, Tyler H.
Garvin, Jennifer A. Akiyama, Veena Afzal, Javier Lopez-Rios, Edward M.
Rubin, Diane E. Dickel, Len A. Pennacchio, and Axel Vise
Before you read this paper |
2017/ 1/16
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Yuzuru KATO |
germ cell determination
Induction of germ cell formation by oskar
Anne Ephrussi, Ruth Lehmann
Before you read this paper |
2017/ 1/23
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Tsuyoshi KOIDE |
Early experience and
epigenetic modification
Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress
Dong Liu,
Josie Diorio,
Beth Tannenbaum,
Christian Caldji,
Darlene Francis,
Alison Freedman,
Shakti Sharma,
Deborah Pearson,
Paul M. Plotsky,
Michael J. Meaney
Science. 1997 Sep 12;277(5332):1659-62.
Epigenetic programming by maternal behavior.
Weaver IC1, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR,
Dymov S, Szyf M, Meaney MJ.
Nat Neurosci. 2004 Aug;7(8):847-54.
Before you read this paper
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The reading list and the course schedule is tentative and is subject to change.
使用する論文は変更される可能性があります． |
Appropriate grade level and Eligible Departments: (x) 1, (x) 2, (x) 3, (x) 4, (x) 5:
( ) School of Life Science， (x) All Departments，( ) Other |
Grades:
To obtain credit one must attend five or more classes (of total of eight classes) . Grades (A, B, C, D) will be determined based on the extent of participation in class.
単位取得には８セッションのうち５つ以上に出席する必要があります．成績（A,B,C,D）はクラスへの参加の程度によって判定します．
Notes:
Developmental Biology II-IV is a discussion-based course involving critical reading of the primary literature. Each year, one of the three courses (Developmental Biology II, III, or IV) will be offered, with no overlap in the material used. Taking any one of the three courses will likely give you an idea what development is about. If you wish to specialize in the field of Developmental Biology, we recommend taking all three courses.
発生生物学II-IVは原著論文をネタに議論する形式で行います．毎年3つの科目のどれか（発生生物学II, IIIまたはIV）が開講され，これら３科目での使用論文の重複はありません．どの科目を履修しても発生生物学の「味見」はできるでしょう．自分で発生研究を志しているなら３科目全てを聞いてみることをお勧めします．
Reading lists for the previous years:
2015
2014 2013 2012 2011 2010 2009 2008 2007 2006
Other courses in developmental biology
Developmental Biology I (e-learning course, in Japanese)
Developmental Biology (offered in the Department of Basic Biology)
Reproductive Biology (offered in the Department of Basic Biology)
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