Developmental Biology II (2016) Syllabus
発生生物学 II (2016) シラバス

Course description :
Various developmental events, such as cell fate determination, cell differentiation, morphogenesis and animal behavior will be analyzed in light of gene expression, cell-cell interaction, intracellular signaling and evolution. Classes will be run by critical reading of the primary literature and discussion.


Course purpose:
Development can be viewed as an integral of molecular and cell biological events, and also is a process though which evolutionary changes in form is generated. Through discussing how the principles and concepts of developmental biology developed and what kind of new challenges they generate, students are expected to nurture their framework in which they conduct their own work in various disciplines.

科目の目的 :

This course will introduce basic principles and concepts of that direct developmental phenomena. Various developmental events, such as cell fate determination, cell differentiation, morphogenesis and animal behavior will be analyzed in light of gene expression, cell-cell interaction, intracellular signaling and evolution.Classes will be run by critical reading of the primary literature and discussion. Please download the paper from links below and take a look at it in advance. It is not necessary to have completely understood the paper before coming to class. This course will be conducted in English. For questions and coments in Japanese, lecturers will provide simultaneous translation service to English.



Time: 13:30 - 15:10 on Mondays 月曜13:30-15:10

Place: National Institute of Genetics, B202 (Library 2nd floor seminar room) 遺伝研B202(図書館2階)
This course is also offered as a part of the Integrative Bioscience Education Program.
People in other departments/institutions can participate in this class using the remote lecture system.

Cource organizer: Yumiko Saga 相賀 裕美子 Participating faculty 担当教員リスト

Date Lecturers Topic and paper
Discovery of odorant receptors and development of the olfactory system
A novel multigene family may encode odorant receptors: a molecular basis for odor recognition.
1991 Apr 5;65(1):175-87. Buck L1, Axel R.
Before you read this paper
Hitoshi SAWA Cell-cell signaling
Pattern formation during vulval development in C. elegans.
Sternberg PW, Horvitz HR
Cell 44: 761-772, 1986
Before you read this paper
Katsutoshi TSUDA

Regulation of organ initiation in plant
Regulation of phyllotaxis by polar auxin transport
Didier Reinhardt, Eva-Rachele Pesce, Pia Stieger, Therese Mandel, Kurt Baltensperger, Malcolm Bennett, Jan Traas, Jir˘ı´ Friml, ris Kuhlemeier
Before you read this paper

Yan ZHU Matrix elasticity and cell lineage determination
Matrix Elasticity Directs Stem Cell Lineage Specification
Adam J. Engler, Shamik Sen, H. Lee Sweeney, Dennis E. Discher
Before you read this paper
2016/12/ 5 Yumiko SAGA Temporal coliniality with Hox genes
Uncoupling time and space in the collinear regulation of Hox genes.
Tschopp P, Tarchini B, Spitz F, Zakany J, Duboule D.
PLoS Genet. 2009 Mar;5(3):e1000398.
参考論文(reference papers)
Gene transpositions in the HoxD complex reveal a hierarchy of regulatory controls.
van der Hoeven F, Zakany J, Duboule D.
Cell. 1996 Jun 28;85(7):1025-35
Breaking Colinearity in the Mouse HoxD Complex
Takashi Kondo and Denis Duboule
Cell, Vol. 97, 407-417, 1999
Before you read this paper
Toshihiko SHIROISHI Evolution of cis-regulatory elements
Progressive Loss of Function in a Limb Enhancer during Snake Evolution
Evgeny Z. Kvon, Olga K. Kamneva, Uira´ S. Melo, Iros Barozzi, Marco Osterwalder, Brandon J. Mannion, Virginie Tissie`res, Catherine S. Pickle, Ingrid Plajzer-Frick, Elizabeth A. Lee, Momoe Kato, Tyler H. Garvin, Jennifer A. Akiyama, Veena Afzal, Javier Lopez-Rios, Edward M. Rubin, Diane E. Dickel, Len A. Pennacchio, and Axel Vise
Before you read this paper
2017/ 1/16
Yuzuru KATO germ cell determination
Induction of germ cell formation by oskar
Anne Ephrussi, Ruth Lehmann
Before you read this paper
2017/ 1/23
Tsuyoshi KOIDE

Early experience and epigenetic modification
Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress
Dong Liu, Josie Diorio, Beth Tannenbaum, Christian Caldji, Darlene Francis, Alison Freedman, Shakti Sharma, Deborah Pearson, Paul M. Plotsky, Michael J. Meaney
Science. 1997 Sep 12;277(5332):1659-62.
Epigenetic programming by maternal behavior.
Weaver IC1, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ.
Nat Neurosci. 2004 Aug;7(8):847-54.
Before you read this paper

The reading list and the course schedule is tentative and is subject to change.
Appropriate grade level and Eligible Departments: (x) 1, (x) 2, (x) 3, (x) 4, (x) 5:
( ) School of Life Science, (x) All Departments,( ) Other

To obtain credit one must attend five or more classes (of total of eight classes) . Grades (A, B, C, D) will be determined based on the extent of participation in class.

Developmental Biology II-IV is a discussion-based course involving critical reading of the primary literature. Each year, one of the three courses (Developmental Biology II, III, or IV) will be offered, with no overlap in the material used. Taking any one of the three courses will likely give you an idea what development is about. If you wish to specialize in the field of Developmental Biology, we recommend taking all three courses.
発生生物学II-IVは原著論文をネタに議論する形式で行います.毎年3つの科目のどれか(発生生物学II, IIIまたはIV)が開講され,これら3科目での使用論文の重複はありません.どの科目を履修しても発生生物学の「味見」はできるでしょう.自分で発生研究を志しているなら3科目全てを聞いてみることをお勧めします.

Reading lists for the previous years: 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006


Other courses in developmental biology

Developmental Biology I (e-learning course, in Japanese)

Developmental Biology (offered in the Department of Basic Biology)

Reproductive Biology (offered in the Department of Basic Biology)

Participating faculty:

name email phone
岩里 琢治 6773 C408
Hitoshi SAWA
澤 斉



Katsutoshi TSUDA
津田 勝利






Yumiko SAGA
相賀 裕美子



城石 俊彦



Yuzuru KATO
加藤 譲



Tsuyoshi KOIDE
小出 剛




last updated 161018