Course description :
Various developmental events, such as cell fate determination, cell differentiation, morphogenesis and animal behavior will be analyzed in light of gene expression, cell-cell interaction, intracellular signaling and evolution. Classes will be run by critical reading of the primary literature and discussion.
科目の概要:
細胞運命決定、細胞分化、形態形成や個体の行動制御等の個体発生の様々な現象を、遺伝子発現調節、細胞間相互作用、細胞内情報伝達等の分子機構や進化の視点から議論し、論文講読とディスカッションを通した演習を行う。（講義）
Course purpose:
Development can be viewed as an integral of molecular and cell biological events, and also is a process though which evolutionary changes in form is generated. Through discussing how the principles and concepts of developmental biology developed and what kind of new challenges they generate, students are expected to nurture their framework in which they conduct their own work in various disciplines.
科目の目的 :
発生現象は分子細胞学的現象が「積分」されたものと捉えることができます。また、発生過程は形態変化の進化がおこる場所でもあります。この授業では、発生生物学の様々な原理や概念がどのようにして生まれ、どのような新たな問題を生み出すかを議論することを通じ、各自が自分の分野での研究の枠組みを作るのに役立ててもらうことを目指しています。
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Contents:
This course will introduce basic principles and concepts of that direct developmental phenomena. Various developmental events, such as cell fate determination, cell differentiation, morphogenesis and animal behavior will be analyzed in light of gene expression, cell-cell interaction, intracellular signaling and evolution. Classes will be run by critical reading of the primary literature and discussion. Please download the paper from links below and take a look at it in advance. It is not necessary to have completely understood the paper before coming to class. This course will be conducted in English. For questions and comments in Japanese, lecturers will provide simultaneous translation service to English.
授業内容:
授業計画：この授業では個体発生を指令する様々な基本原理や概念をとりあげます。細胞運命決定、細胞分化、形態変化、行動等のイベントについて、遺伝子発現、細胞間相互作用、シグナル伝達や進化等の観点から分析します。この授業は「原著論文を読んで議論する」という形式で行います。前もって論文を以下のリンクからダウンロードし、目を通しておいてください。完全に理解する必要はありません。この授業は英語で行いますが、日本語での質問やコメントに対しては講師が同時通訳サービスを提供します。 |
Time: 13:30 - 15:10 on Mondays 月曜13:30-15:10
Place: National Institute of Genetics, B301 (Library 3rd floor seminar room) 遺伝研B301(図書館３階）
People in other departments/institutions can participate in this class using the remote lecture system.
他専攻の方は遠隔講義システムで受講できます．
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| Cource organizer: SAWA Hitoshi 澤 斉 |
Participating faculty 担当教員リスト |
Schedule:
| Date |
Lecturers |
Topic and paper |
2022/11/ 7
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SAWA Hitoshi
澤 斉 |
Asymmetric division and phase separation
Germline P granules are liquid droplets that localize by controlled dissolution/condensation (PDF)
Clifford P. Brangwynne, Christian R. Eckmann, David S. Courson, Agata Rybarska, Carsten Hoege, Jobin Gharakhani,
Frank Julicher, and Anthony A. Hyman
Science, 324 (5935), DOI: 10.1126/science.1172046
Before you read this paper
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2022/11/21
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TSUDA Katsutoshi
津田 勝利 |
Signal canalization for tissue differentiation
Polarity and the Induction of Organized Vascular Tissues (PDF)
Author(s): T. SACHS
Source: Annals of Botany, MARCH 1969, New Series, Vol. 33, No. 130 (MARCH 1969), pp.
263-275 Published by: Oxford University Press
Before you read this paper
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2022/12/ 5
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NOSAKA-T Misuzu
野坂 実鈴 |
Mechanical stress and morphogenesis
Elastic Domains Regulate Growth and Organogenesis in the Plant Shoot Apical
Meristem (PDF)
Daniel Kierzkowski, Naomi Nakayama, Anne-Lise Routier-Kierzkowska, Alain Weber, Emmanuelle Bayer, Martine
Schorderet, Didier Reinhardt, Cris Kuhlemeier, and Richard S. Smith
Science, 335 (6072), DOI: 10.1126/science.1213100
Before you read this paper
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2022/12/12
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SAKAI Noriyoshi
酒井 則良 |
Stem cell niche
decapentaplegic Is Essential for the Maintenance and Division of Germline Stem Cells in the Drosophila Ovary (PDF)
Xie T. and Spradling AC.
Cell 1998 Jul 24;94(2):251-60. doi: 10.1016/s0092-8674(00)81424-5. PMID: 9695953
Before you read this paper
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2022/12/19
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YONEHARA Keisuke
米原 圭祐 |
Body axes determination
Left-right asymmetric expression of the TGFβ-family member lefty in mouse embryos (PDF)
Meno, C., Saijoh, Y., Fujii, H. et al.
Left-right asymmetric expression of the TGFβ-family member lefty in mouse embryos.
Nature 381, 151-155 (1996).
Before you read this paper
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| 2022/12/26 |
KAWAKAMI Koichi
川上 浩一
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Genetic compensation
Genetic compensation induced by deleterious mutations but not gene knockdowns (PDF)
Andrea Rossi, Zacharias Kontarakis, Claudia Gerri, Hendrik Nolte, Soraya Hölper, Marcus Krüger & Didier Y. R. Stainier
Nature volume 524, pages230-233 (2015) doi:10.1038/nature14580
Before you read this paper
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2023/ 1/16
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NAKAGAWA Naoki
中川 直樹 |
Gyrification of the cerebral cortex
Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion (PDF)
Marta Florio, Mareike Albert, Elena Taverna, Takashi Namba, Holger Brandl, Eric Lewitus, Christiane Haffner, Alex Sykes, Fong Kuan Wong, Jula Peters, Elaine Guhr, Sylvia Klemroth, Kay Prüfer, Janet Kelso, Ronald Naumann, Ina Nüsslein, Andreas Dahl, Robert Lachmann, Svante Pääbo, and Wieland B. Huttner
Science, 347 (6229), DOI: 10.1126/science.aaa1975
Before you read this paper
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2023/ 1/23
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KAWASAKI Takahiko
川崎 能彦 |
Environmental factors involved in development
Prenatal acoustic communication programs offspring for high posthatching temperatures
in a songbird (PDF)
Mariette M, Buchanan K. (2016)
Science, 353 (6301), DOI: 10.1126/science.aaf7049
Before you read this paper
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The reading list and the course schedule is tentative and is subject to change.
使用する論文は変更される可能性があります． |
Appropriate grade level and Eligible Departments: (x) 1, (x) 2, (x) 3, (x) 4, (x) 5:
( ) School of Life Science， (x) All Departments，( ) Other |
Pre-requisites: Familiarity with basic concepts of Molecular and Cell Biology is recommended.
This course will be conducted in English. For questions and comments in Japanese, lecturers will provide simultaneous translation service to English.
履修条件：分子細胞生物学の基礎的知識があるとより楽しめるでしょう。
その他：この授業は英語で行いますが、日本語での質問やコメントに対しては講師が同時通訳サービスを提供します。
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Grades:
To obtain credit one must attend five or more classes (of total of eight classes) . Grades (A, B, C, D) will be determined based on the activity of discussion with lecturer and other students.
単位取得には８セッションのうち５つ以上に出席する必要があります．成績（A,B,C,D）は講師や他の学生との議論への参加の程度によって判定します．
Notes:
Developmental Biology II-IV is a discussion-based course involving critical reading of the primary literature. Each year, one of the three courses (Developmental Biology II, III, or IV) will be offered, with no overlap in the material used. Taking any one of the three courses will likely give you an idea what development is about. If you wish to specialize in the field of Developmental Biology, we recommend taking all three courses.
発生生物学II-IVは原著論文をネタに議論する形式で行います．毎年3つの科目のどれか（発生生物学II, IIIまたはIV）が開講され，これら３科目での使用論文の重複はありません．どの科目を履修しても発生生物学の「味見」はできるでしょう．自分で発生研究を志しているなら３科目全てを聞いてみることをお勧めします．
Reading lists for the previous years:
2021
2020
2019
2018
2017
2016
2015
2014
2013
2012
2011
2010
2009
2008
2007
2006
Other courses in developmental biology
Developmental Biology I (e-learning course, in Japanese)
Developmental Biology (offered in the Department of Basic Biology)
Reproductive Biology (offered in the Department of Basic Biology)
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