Development can be viewed as an integral of
molecular and cell biological events, and also is a process though
which evolutionary changes in form is generated Through discussing how
the principles and concepts of developmental biology developed and what
kind of new challenges they generate, students are expected to nurture
their framework in which they conduct their own work in various
Familiarity with basic concepts of Molecular and Cell Biology is recommended.
||Topic and paper
|Developmental transition in early embryos
Newport J, Kirschner M.
A major developmental transition in early Xenopus embryos I, II
Cell 30: 675-686 and 687-696, 1982
|| Kazuo EMOTO (*)
|Novel cellular mechanisms in neuronal plasticity
Grubb MS, Burrone J
Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability
Nature 465: 1070-1074, 2010
Kuba H, Oichi Y, Ohmori H
Presynaptic activity regulates Na1 channel distribution at the axon initial segment.
Nature 465: 1075-1078, 2010
Proliferation of plant germline
Kim HJ, Oh SA, Brownfield L, Hong SH, Ryu H, Hwang I, Twell D, Nam HG
Control of plant germline proliferation by SCF(FBL17) degradation of cell cycle inhibitors.
Nature 455:1134-1137, 2008
|Differential adhesion as a mechanism of morphogenesis
Reconstruction of tissues by dissociated cells.
Science 141:401-408, 1963
Steinberg MS, Takeichi M.
Experimental specification of cell sorting, tissue spreading, and specific spatial patterning by quantitative differences in cadherin expression.
Proc Natl Acad Sci USA 91:206-209, 1994
Link between speciation and sex chromosome
Kitano J, Ross JA, Mori S, Kume M, Jones FC, Chan YF, Absher DM, Grimwood J, Schmutz J, Myers RM, Kingsley DM, Peichel CL.
A role for a neo-sex chromosome in stickleback speciation.
Nature 461: 1079-83, 2009
|| Koichi KAWAKAMI
FGF signaling in brain patterning
Cholfin JA, Rubenstein JL.
Patterning of frontal cortex subdivisions by Fgf17.
Proc Natl Acad Sci USA 104:7652-7657, 2007
Storm EE, Garel S, Borello U, Hebert JM, Martinez S, McConnell SK, Martin GR, Rubenstein JL.
Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers.
Development 133:1831-1844, 2006
|Role of neural activity in the neural development
Borodinsky LN, Root CM, Cronin JA, Sann SB, Gu X, Spitzer NC
Activity-dependent homeostatic specification of transmitter expression in embryonic neurons.
Nature 429: 523-530, 2004
|Ocular dominance column development in the primary visual cortex
Crowley JC and Katz LC
Development of ocular dominance columns in the absence of retinal input.
Nat Neurosci. 2:1125-1130, 1999
Crowley JC and Katz LC
Early development of ocular dominance columns.
Science 290:1321-1324, 2000
The reading list and the course
schedule is tentative and is subject to change.
(*) special guest lecturer
To obtain credit one must attend five or more classes (of total of eight classes) . Grades (Pass/Fail) will be determined based on the
extent of participation in class.
Developmental Biology II, III, and IV will all be
done in the same style, critical reading of the primary literature,
covering various topics in developmental biology. Students must read
the assigned paper before coming to the class. Active participation in
discussion is essential. There will be no overlap in the teaching
material that will be used in Developmental Biology II, III, and IV.
Taking any one of the three courses will likely give you an idea what
development is about. If you wish to specialize in the field of
Developmental Biology, we recommend taking all three courses.
Reading lists for the previous years: 2009 2008 2007 2006
For students who are unable to appreciate scientific discussions in
English, the course organizer will offer a one-hour discussion session
in Japanese for each class. To schedule a discussion session, read the
assigned paper and send an email to the course organizer, listing three
issues/problems that you would like to discuss. The deadline for
scheduling an appointment is 13:30 of the day of the class (Friday).
Indicate the time of the day that does not suit you, during the period
of Monday following the class to Friday of the next week.