Developmental Biology III (2011) Syllabus

Course objectives:
Development can be viewed as an integral of molecular and cell biological events, and also is a process though which evolutionary changes in form is generated Through discussing how the principles and concepts of developmental biology developed and what kind of new challenges they generate, students are expected to nurture their framework in which they conduct their own work in various disciplines.

Familiarity with basic concepts of Molecular and Cell Biology is recommended.

This course will introduce basic principles and concepts of that direct developmental phenomena. Various developmental events, such as cell fate determination, cell differentiation, morphogenesis and animal behavior will be analyzed in light of gene expression, cell-cell interaction, intracellular signaling and evolution.

Classes will be run by critical reading of the primary literature and discussion. Please download the paper from links below and take a look at it in advance. It is not necessary to have completely understood the paper before coming to class.

This course will be conducted in English.

Time: 13:30 - 15:10 on Fridays

Place: National Institute of Genetics, B202 (Library 2nd floor seminar room)
This course is also offered as a part of the "Integrated Brain Science I, II" of the SOKENDAI Brain Science Joint Project.
People in other departments/institutions can participate in this class using the remote lecture system.

Cource organizer: Yasushi HIROMI Participating faculty

Date Lecturers Topic and paper

Yasushi HIROMI

Asymmetric division
Rhyu MS, Jan L, Jan YN
Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells.
Cell 76: 477-491, 1994

An advice on how to read this paper @

2011/11/4 Kazuki HORIKAWA
Yasushi HIROMI

Morphogen gradient
Gregor T, McGregor AP, Bialek, Wieschaus E
Stability and nuclear dynamics of the Bicoid morphogen gradient.
Cell 130: 141-152, 2007

Introduction to the paper

2011/11/11 Noriyoshi SAKAI
Yasushi HIROMI

Germ-line stem cells
Brinster RL, Avarbock MR
Germline transmision of donor haplotype following spermatogonial transplantation.
PNAS 91: 11303-11307, 1994
Brinster RL, Zimmermann JW
Spermatogenesis following male germ-cell transplantation.
PNAS 91: 11298-11302, 1994

Before you read these papers

2011/11/18 Miho ASAOKA
Yasushi HIROMI

Stem cell "niche"
Xie T, Spradling AC
A niche maintaining germ line stem cells in the Drosophila ovary.
Science 290: 328-330, 2000

Before you read this paper

2011/11/25 Toshihiko SHIROISHI
Yasushi HIROMI

Evolution of morphology
Tamura K, Nomura N, Seki R, Yonei-Tamura S, Yokoyama H
Embryological evidence identifies wing digits in birds as digits 1, 2, and 3.
Science 331: 753-757, 2011

Before you read this paper

2012/1/20 Kazuhide ASAKAWA
Yasushi HIROMI

Embryonic movement in organogenesis
Kahn J, Schwartz Y, et al.
Muscle contraction is necessary to maintain joint progenitor cell fate.
Developmental Cell 16: 734-743, 2009

Before you read this paper

2012/1/27 Ryu UEDA
Yasushi HIROMI

Organ specification
Halder G, Callaerts P , Gehring WJ
Induction of ectopic eyes by targetted expression of the eyeless gene of Drosophila
Science 267: 1788-1792, 1995

Before you read this paper

Yasushi HIROMI
Tatsumi HIRATA

Making a difference among multiple nuclei within a single cell
Sanes JR, Johnson YR, Kotzbauer PT, Mudd J, Hanley T, Martinou JC, Merlie JP
Selective expression of an acetylcholine receptor-lacZ transgene in synaptic nuclei of adult muscle fibers.
Development 113: 1181-1190, 1991

Before you read this paper

The reading list and the course schedule is tentative and is subject to change.
Appropriate grade level and Eligible Departments: (x) 1, (x) 2, (x) 3, (x) 4, (x) 5:
( ) School of Life ScienceC (x) All DepartmentsC( ) Other

To obtain credit one must attend five or more classes (of total of eight classes) . Grades (A, B, C, D) will be determined based on the extent of participation in class.

Developmental Biology II, III, and IV will all be done in the same style, critical reading of the primary literature, covering various topics in developmental biology. Students must read the assigned paper before coming to the class. Active participation in discussion is essential. There will be no overlap in the teaching material that will be used in Developmental Biology II, III, and IV. Taking any one of the three courses will likely give you an idea what development is about. If you wish to specialize in the field of Developmental Biology, we recommend taking all three courses.

Reading lists for the previous years: 2010 2009 2008 2007 2006

For students who are unable to appreciate scientific discussions in English, the course organizer will offer a one-hour discussion session in Japanese for each class. To schedule a discussion session, read the assigned paper and send an email to the course organizer, listing three issues/problems that you would like to discuss. The deadline for scheduling an appointment is 13:30 of the day of the class (Friday). Indicate the time of the day that does not suit you, during the period of Monday following the class to Friday of the next week.

Participating faculty:

name email
Hiromi HIRATA hihirata 5825 C214
Tatsumi HIRATA tathirat 6721 C518
Yasushi HIROMI yhiromi 6767 C415
Kazuki HORIKAWA khorikaw 6799 C218
Takuji IWASATO tiwasato 6773 C408
Tsuyoshi KOIDE tkoide 5843 X209
Yumiko SAGA ysaga 6829 R221
Hitoshi SAWA hisawa 6845 G307
Noriyoshi SAKAI nosakai 5848 S109
Toshihiko SHIROISHI tshirois 6818 R115
Ryu UEDA rueda 6823 R205


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