Course objectives:
Development can be viewed as an integral of
molecular and cell biological events, and also is a process though
which evolutionary changes in form is generated Through discussing how
the principles and concepts of developmental biology developed and what
kind of new challenges they generate, students are expected to nurture
their framework in which they conduct their own work in various
disciplines.
Prerequisites:
Familiarity with basic concepts of Molecular and Cell Biology is recommended. |
Contents:
This course will introduce basic principles and concepts of that direct
developmental phenomena. Various developmental events, such as cell fate
determination, cell
differentiation, morphogenesis and animal behavior will be analyzed in
light of gene expression, cell-cell interaction, intracellular
signaling and evolution.
Classes will be run by critical reading of the
primary literature and discussion. Please download the paper from links below and take a look at it in advance. It is not necessary to have completely understood the paper before coming to class.
This course will be conducted in English. |
Time: 13:30 - 15:10 on Fridays
Place: National Institute of Genetics, B202 (Library 2nd floor seminar room)
This course is also offered as a part of the "Integrated Brain Science I, II" of the SOKENDAI Brain Science Joint Project.
People in other departments/institutions can participate in this class using the remote lecture system.
|
| Cource organizer: Yasushi HIROMI |
Participating faculty |
Schedule:
| Date |
Lecturers |
Topic and paper |
| 2011/10/28 |
Yasushi HIROMI
Mitsuru MORIMOTO |
Asymmetric division
Rhyu MS, Jan L, Jan YN
Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells.
Cell 76: 477-491, 1994
An advice on how to read this paper @
Quiz |
| 2011/11/4 |
Kazuki HORIKAWA
Yasushi HIROMI |
Morphogen gradient
Gregor T, McGregor AP, Bialek, Wieschaus E
Stability and nuclear dynamics of the Bicoid morphogen gradient.
Cell 130: 141-152, 2007
Introduction to the paper |
| 2011/11/11 |
Noriyoshi SAKAI
Yasushi HIROMI |
Germ-line stem cells
Brinster RL, Avarbock MR
Germline transmision of donor haplotype following spermatogonial transplantation.
PNAS 91: 11303-11307, 1994
Brinster RL, Zimmermann JW
Spermatogenesis following male germ-cell transplantation.
PNAS 91: 11298-11302, 1994
Before you read these papers |
| 2011/11/18 |
Miho ASAOKA
Yasushi HIROMI |
Stem cell "niche"
Xie T, Spradling AC
A niche maintaining germ line stem cells in the Drosophila ovary.
Science 290: 328-330, 2000
Before you read this paper |
| 2011/11/25 |
Toshihiko SHIROISHI
Yasushi HIROMI |
Evolution of morphology
Tamura K, Nomura N, Seki R, Yonei-Tamura S, Yokoyama H
Embryological evidence identifies wing digits in birds as digits 1, 2, and 3.
Science 331: 753-757, 2011
Before you read this paper |
| 2012/1/20 |
Kazuhide ASAKAWA
Yasushi HIROMI |
Embryonic movement in organogenesis
Kahn J, Schwartz Y, et al.
Muscle contraction is necessary to maintain joint progenitor cell fate.
Developmental Cell 16: 734-743, 2009
Before you read this paper |
| 2012/1/27 |
Ryu UEDA
Yasushi HIROMI |
Organ specification
Halder G, Callaerts P , Gehring WJ
Induction of ectopic eyes by targetted expression of the eyeless gene of Drosophila
Science 267: 1788-1792, 1995
Before you read this paper |
2012/2/10
|
Yasushi HIROMI
Tatsumi HIRATA
|
Making a difference among multiple nuclei within a single cell
Sanes JR, Johnson YR, Kotzbauer PT, Mudd J, Hanley T, Martinou JC, Merlie JP
Selective expression of an acetylcholine receptor-lacZ transgene in synaptic nuclei of adult muscle fibers.
Development 113: 1181-1190, 1991
Before you read this paper |
The reading list and the course
schedule is tentative and is subject to change. |
Appropriate grade level and Eligible Departments: (x) 1, (x) 2, (x) 3, (x) 4, (x) 5:
( ) School of Life ScienceC (x) All DepartmentsC( ) Other |
Grades:
To obtain credit one must attend five or more classes (of total of eight classes) . Grades (A, B, C, D) will be determined based on the
extent of participation in class.
Notes:
Developmental Biology II, III, and IV will all be
done in the same style, critical reading of the primary literature,
covering various topics in developmental biology. Students must read
the assigned paper before coming to the class. Active participation in discussion is essential. There will be no overlap in the teaching
material that will be used in Developmental Biology II, III, and IV.
Taking any one of the three courses will likely give you an idea what
development is about. If you wish to specialize in the field of
Developmental Biology, we recommend taking all three courses.
Reading lists for the previous years: 2010 2009 2008 2007 2006
For students who are unable to appreciate scientific discussions in
English, the course organizer will offer a one-hour discussion session
in Japanese for each class. To schedule a discussion session, read the
assigned paper and send an email to the course organizer, listing three
issues/problems that you would like to discuss. The deadline for
scheduling an appointment is 13:30 of the day of the class (Friday).
Indicate the time of the day that does not suit you, during the period
of Monday following the class to Friday of the next week. |