Developmental Biology IV (2012) Syllabus

Course objectives:
Development can be viewed as an integral of molecular and cell biological events, and also is a process though which evolutionary changes in form is generated Through discussing how the principles and concepts of developmental biology developed and what kind of new challenges they generate, students are expected to nurture their framework in which they conduct their own work in various disciplines.

Familiarity with basic concepts of Molecular and Cell Biology is recommended.

This course will introduce basic principles and concepts of that direct developmental phenomena. Various developmental events, such as cell fate determination, cell differentiation, morphogenesis and animal behavior will be analyzed in light of gene expression, cell-cell interaction, intracellular signaling and evolution.

Classes will be run by critical reading of the primary literature and discussion. Please download the paper from links below and take a look at it in advance. It is not necessary to have completely understood the paper before coming to class.

This course will be conducted in English.

Time: 13:30 - 15:10 on Mondays (except for 4 sessions in November, when the class will be held in 15:20-17:00)

Place: National Institute of Genetics, B202 (Library 2nd floor seminar room)
This course is also offered as a part of the "Integrated Brain Science I, II" of the SOKENDAI Brain Science Joint Project.
People in other departments/institutions can participate in this class using the remote lecture system.

Cource organizer: Yasushi HIROMI Participating faculty

Date Lecturers Topic and paper
Yasushi HIROMI

Cellular autonomy
Hake S and Freeling M
Analysis of genetic mosaics show that the extra epidermal cell divisions in Knotted mutant maize plants are induced by adjacent mesophiyll cells.
Nature 320: 621-623, 1986

How to obtain this paper
Introduction to the paper

Yasushi HIROMI

Cell cycle regulation
Newport JW, Kirschner MW
Regulation of the cell cycle during early Xenopus development.
Cell 37: 731-742, 1984

Before you read this paper

Hitoshi SAWA
Yasushi HIROMI

Cell-cell signaling
Sternberg PW, Horvitz HR
Pattern formation during vulval development in C. elegans.
Cell 44: 761-772, 1986

Before you read this paper

Yasushi HIROMI

Reprogramming of cell fates
Davis RL, Weintraub H, Lassar AB
Expression of a single transfected cDNA converts fibroblasts to myoblasts.
Cell 51: 987-1000, 1987

Before you read this paper

Yumiko SAGA
Yasushi HIROMI

Symmetry breaking of the embryo
Nonaka S, Shiratori H, Saijoh Y, Hamada H
Determ ination of left|right patterning of the mouse embryo by artificial nodal flow
Nature 418:96-99, 2002

Before you read this paper

Tsuyoshi KOIDE
Yasushi HIROMI

Epigenetic reprogramming in cloned embryos
Dean W, Santos F, Stojkovic M, Zakhartchenko V, Walter J, Wolf E, Reik W
Conservation of methylation reprogramming in mammalian development: Aberrant reprogramming in cloned embryos.
PNAS 98: 13734-13738, 2001

Before you read this paper

Yasushi HIROMI

Activity-dependent development of neuronal circuits
Stellwagen D, Shatz CJ
An instructive role for retinal waves in the development of retinogeniculate connectivity
Neuron 33: 357-367, 2002

Before you read this paper

Yasushi HIROMI

Neurogenetic dissection of memory
McGuire SE, Le PT, Osborn AJ, Matsumoto K, Davis RL
Spatiotemporal rescue of memory dysfunction in Drosophila.
Science 302:1765-1768, 2003

Before you read this paper

The reading list and the course schedule is tentative and is subject to change.
Appropriate grade level and Eligible Departments: (x) 1, (x) 2, (x) 3, (x) 4, (x) 5:
( ) School of Life ScienceC (x) All DepartmentsC( ) Other

To obtain credit one must attend five or more classes (of total of eight classes) . Grades (A, B, C, D) will be determined based on the extent of participation in class.

Developmental Biology II-IV is a discussion-based course involving critical reading of the primary literature. Each year, one of the three courses (Developmental Biology II, III, or IV) will be offered, with no overlap in the material used. Taking any one of the three courses will likely give you an idea what development is about. If you wish to specialize in the field of Developmental Biology, we recommend taking all three courses.

Reading lists for the previous years: 2011 2010 2009 2008 2007 2006


Other courses in developmental biology

Developmental Biology I (e-learning course, in Japanese)

Developmental Biology (offered in the Department of Basic Biology)

Reproductive Biology (offered in the Department of Basic Biology)

Participating faculty:

name email
Hiromi HIRATA hihirata 5825 C214
Tatsumi HIRATA tathirat 6721 C518
Yasushi HIROMI yhiromi 6767 C415
Takuji IWASATO tiwasato 6773 C408
Tsuyoshi KOIDE tkoide 5843 X209
Yumiko SAGA ysaga 6829 R221
Hitoshi SAWA hisawa 6845 G307
Noriyoshi SAKAI nosakai 5848 S109
Toshihiko SHIROISHI tshirois 6818 R115
Ryu UEDA rueda 6823 R205


last updated 121220