Developmental Biology III 2008

Developmental Biology III 2008

syllabus

Various developmental events, such as cell fate determination, cell differentiation, morphogenesis and animal behavior will be analyzed in light of gene expression, cell-cell interaction, intracellular signaling and evolution. Classes will be run by critical reading of the primary literature and discussion. It is essential that you have read the papers before coming to the class. Please download the papers from the links provided below.

This course will be run in English.

Date/Time: Friday 13:30-15:10
Location: Library 2nd floor seminar room (B201)

Course organizer: Yasushi HIROMI (NIG)

Date Moderator Content

2008/10/31

Yasushi HIROMI
Minori SHINYA

Timing of developmenttal events
Newport J, Kirschner M.
A major developmental transition in early Xenopus embryos I, II
Cell 30: 675-686 and 687-696, 1982.　
assignment

2008/11/7
Hiroyuki SASAKI
Yasushi HIROMI
Pluripotential gene
Takahashi K, Yamanaka S.
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
Cell 126: 663-676, 2006.　
assignment

2008/11/14
Isao KATSURA
Yasushi HIROMI
Comparative genomics for a proteome
Li JB, Gerdes JM, Haycraft CJ, et al.
Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene.
Cell 117: 541-552, 2004.　
assignment

2008/11/21
Koichi KAWAKAMI
Yasushi HIROMI
Micro RNA in development
Choi WY, Giraldez AJ, Schier AF.
Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430.
Science 318: 271-274, 2008.

Giraldez AJ, Mishima Y, Rihel J,et al.
Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs.
Science 312: 75-79, 2006.　
assignment

2008/11/28

Yasushi HIROMI
Toshiyuki TAKANO

Cell competition
Moreno E, Basler K, Morata G.
Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development.
Nature 415: 755-759, 2002. 　
assignment

2008/12/19
Kazuo EMOTO
Yasushi HIROMI
Self-organization of biological membranes
Simons K, Ikonen E.
Functional rafts in cell membranes.
Nature 387: 569-72, 1997.　
assignment

2009/1/9
Takuji IWASATO
Yasushi HIROMI
Differentiation of olfactory sensory neurons
Li J, Ishii T, Feinstein P, Mombaerts P
Odorant receptor gene choice is reset by nuclear transfer from mouse olfactory sensory neurons.
Nature 428, 393-399, 2004.

Eggan K, Baldwin K, Tackett M, et al.
Mice cloned from olfactory sensory neurons.
Nature 428, 44-49, 2004.
assignment

2008/1/16
Yasushi HIROMI
Toshiyuki TAKANO
Systems biology approach to development
De Renzis S, Elemento O, Tavazoie S, Wieschaus EF
Unmasking activation of the zygotic genome using chromosomal deletions in the Drosophila embryo.
PLoS Biology 5: 1036-1051, 2007.　
assignment

Developmental Biology II, III, and IV will all be done in the same style, critical reading of the primary literature, covering various topics in developmental biology. Students must read the assigned paper before coming to the class. Active participation in discussion is essential. There will be no overlap in the teaching material that will be used in Developmental Biology II, III, and IV. Taking any one of the three courses will likely give you an idea what development is about. If you wish to specialize in the field of Developmental Biology, we recommend taking all three courses.

　

発生生物学II 2007 Developmental Biology II 2007

発生生物学IV 2006 Developmental Biology IV 2006

遺伝学専攻の授業 Courses at Dept. Genetics

遺伝学専攻ホームページ NIG Graduate Program

遺伝研ホームページ NIG homepage

　

　

last updated 2008/10/17

Date	Moderator	Content
2008/10/31	Yasushi HIROMI Minori SHINYA	Timing of developmenttal events Newport J, Kirschner M. A major developmental transition in early Xenopus embryos I, II Cell 30: 675-686 and 687-696, 1982.　 assignment
2008/11/7	Hiroyuki SASAKI Yasushi HIROMI	Pluripotential gene Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126: 663-676, 2006.　 assignment
2008/11/14	Isao KATSURA Yasushi HIROMI	Comparative genomics for a proteome Li JB, Gerdes JM, Haycraft CJ, et al. Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. Cell 117: 541-552, 2004.　 assignment
2008/11/21	Koichi KAWAKAMI Yasushi HIROMI	Micro RNA in development Choi WY, Giraldez AJ, Schier AF. Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430. Science 318: 271-274, 2008. Giraldez AJ, Mishima Y, Rihel J,et al. Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs. Science 312: 75-79, 2006.　 assignment
2008/11/28	Yasushi HIROMI Toshiyuki TAKANO	Cell competition Moreno E, Basler K, Morata G. Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development. Nature 415: 755-759, 2002. 　 assignment
2008/12/19	Kazuo EMOTO Yasushi HIROMI	Self-organization of biological membranes Simons K, Ikonen E. Functional rafts in cell membranes. Nature 387: 569-72, 1997.　 assignment
2009/1/9	Takuji IWASATO Yasushi HIROMI	Differentiation of olfactory sensory neurons Li J, Ishii T, Feinstein P, Mombaerts P Odorant receptor gene choice is reset by nuclear transfer from mouse olfactory sensory neurons. Nature 428, 393-399, 2004. Eggan K, Baldwin K, Tackett M, et al. Mice cloned from olfactory sensory neurons. Nature 428, 44-49, 2004. assignment
2008/1/16	Yasushi HIROMI Toshiyuki TAKANO	Systems biology approach to development De Renzis S, Elemento O, Tavazoie S, Wieschaus EF Unmasking activation of the zygotic genome using chromosomal deletions in the Drosophila embryo. PLoS Biology 5: 1036-1051, 2007.　 assignment

発生生物学II 2007	Developmental Biology II 2007
発生生物学IV 2006	Developmental Biology IV 2006
遺伝学専攻の授業	Courses at Dept. Genetics
遺伝学専攻ホームページ	NIG Graduate Program
遺伝研ホームページ	NIG homepage