Developmental Biology II (2013) Syllabus 発生生物学 II (2013) シラバス

Course objectives:
Development can be viewed as an integral of molecular and cell biological events, and also is a process though which evolutionary changes in form is generated. Through discussing how the principles and concepts of developmental biology developed and what kind of new challenges they generate, students are expected to nurture their framework in which they conduct their own work in various disciplines.

Familiarity with basic concepts of Molecular and Cell Biology is recommended.

This course will introduce basic principles and concepts of that direct developmental phenomena. Various developmental events, such as cell fate determination, cell differentiation, morphogenesis and animal behavior will be analyzed in light of gene expression, cell-cell interaction, intracellular signaling and evolution.

Classes will be run by critical reading of the primary literature and discussion. Please download the paper from links below and take a look at it in advance. It is not necessary to have completely understood the paper before coming to class.

This course will be conducted in English. For questions and coments in Japanese, lecturers will provide simultaneous translation service to English.

Time: 13:30 - 15:10 on Mondays 月曜13:30-15:10

Place: National Institute of Genetics, B202 (Library 2nd floor seminar room) 遺伝研B202(図書館2階)
This course is also offered as a part of the "Integrated Brain Science I, II" of the SOKENDAI Brain Science Joint Project.
People in other departments/institutions can participate in this class using the remote lecture system.

Cource organizer: Yumiko SAGA 相賀 裕美子 Participating faculty 担当教員リスト

Date Lecturers Topic and paper
Tatsumi HIRATA
Yasushi HIROMI

Developmental genetics
Tan JC, Nocka K, Ray P, Traktman P, Besmer P
The dominant W42 spotting phenotype results from a missense mutation in the c-kit receptor kinase.
Science 247: 209-212, 1990
Before you read this paper

Yuzuru KATO
Yasushi HIROMI

Dosage compensation
Xu N, Tsai C-L, Lee JT
Transient Homologous Chromosome Pairing Marks the Onset of X Inactivation.
Science 311: 114-152, 2006
Before you read this paper

Noriyoshi SAKAI
Yasushi HIROMI

note schedule change

Germ cell plasticity
Kanatsu-Shinohara M, Inoue K, Lee J, Yoshimoto M, Ogonuki N, Miki H, Baba S, Kato T, Kazuki Y, Toyokuni S, Toyoshima M, Niwa O, Oshimura M, Heike T, Nakahata T, Ishino F, Ogura A, Shinohara T
Generation of pluripotent stem cells from neonatal mouse.
Cell 119: 1001-1012, 2004
Before you read this paper

Yasushi HIROMI

note schedule change

Identification of cis-regulatry sequences from large genome data
Shen Y, Yue F, McCleary DF, Ye Z, Edsall L, Kuan S, Wagner U, Dixon J, Lee L, Lobanenkov VV, Ren B
A map of the cis-regulatory sequences in the mouse genome.
Nature 488: 116-120, 2012
Before you read this paper

Shinji IHARA
Yasushi HIROMI

Cell fusion
Mohler WA, Shemer G, del Campo JJ, Valansi C, Opoku-Serebuoh E, Scranton V, Assaf N, White JG, Podbilewicz B
The Type I membrane protein EFF-1 Is essential for developmental cell fusion.
Developmental Cell 2: 355-362, 2002

Before you read this paper

Yasushi HIROMI

Pattern formation/Compartmentalisation
Garcia-Bellido A, Ripoll A, Morata G.
Developmental Compartmentalisation of the Wing Disk of Drosophila.
Nature New Biology 245, 251-253, 1973
Before you read this paper


Hidenobu MIZUNO
Yasushi HIROMI

Cellular mechanisms of memory storage
Martin KC, Casadio A, Zhu H, Yaping E, Rose JC, Chen M, Bailey CH, Kandel ER.
Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage.
Cell 91: 927-938, 1997
Before you read this paper


Yasushi HIROMI
Yumiko SAGA

note schedule change

Mysterious phenotypes
Hiromi Y, Mlodzik M, West SR Rubin GM, Goodman CS
Ectopic expression of seven-up produces cell fate changes during ommatidial assembly.
Development 118: 1123-1135, 1993
Before you read this paper

The reading list and the course schedule is tentative and is subject to change.
Appropriate grade level and Eligible Departments: (x) 1, (x) 2, (x) 3, (x) 4, (x) 5:
( ) School of Life Science, (x) All Departments,( ) Other

To obtain credit one must attend five or more classes (of total of eight classes) . Grades (A, B, C, D) will be determined based on the extent of participation in class.

Developmental Biology II-IV is a discussion-based course involving critical reading of the primary literature. Each year, one of the three courses (Developmental Biology II, III, or IV) will be offered, with no overlap in the material used. Taking any one of the three courses will likely give you an idea what development is about. If you wish to specialize in the field of Developmental Biology, we recommend taking all three courses.
発生生物学II-IVは原著論文をネタに議論する形式で行います.毎年3つの科目のどれか(発生生物学II, IIIまたはIV)が開講され,これら3科目での使用論文の重複はありません.どの科目を履修しても発生生物学の「味見」はできるでしょう.自分で発生研究を志しているなら3科目全てを聞いてみることをお勧めします.

Reading lists for the previous years: 2012 2011 2010 2009 2008 2007 2006


Other courses in developmental biology

Developmental Biology I (e-learning course, in Japanese)

Developmental Biology (offered in the Department of Basic Biology)

Reproductive Biology (offered in the Department of Basic Biology)

Participating faculty:

name email
Hiromi HIRATA  平田 普三 hihirata 5825 C214
Tatsumi HIRATA 平田 たつみ tathirat 6721 C518
Takuji IWASATO 岩里 琢治 tiwasato 6773 C408
Tsuyoshi KOIDE 小出 剛 tkoide 5843 X209
Yumiko SAGA 相賀 裕美子 ysaga 6829 R221
Hitoshi SAWA 澤 斉 hisawa 6845 G307
Noriyoshi SAKAI 酒井 則良 nosakai 5848 S109
Toshihiko SHIROISHI 城石 俊彦 tshirois 6818 R115
Ryu UEDA 上田 龍 rueda 6823 R205


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