Developmental Biology IV (2009) Syllabus

Course objectives:
Development can be viewed as an integral of molecular and cell biological events, and also is a process though which evolutionary changes in form is generated Through discussing how the principles and concepts of developmental biology developed and what kind of new challenges they generate, students are expected to nurture their framework in which they conduct their own work in various disciplines.

Familiarity with basic concepts of Molecular and Cell Biology is recommended.

This course will introduce basic principles and concepts of that direct developmental phenomena. Various developmental events, such as cell fate determination, cell differentiation, morphogenesis and animal behavior will be analyzed in light of gene expression, cell-cell interaction, intracellular signaling and evolution.
Classes will be run by critical reading of the primary literature and discussion. It is essential that you have read the papers before coming to the class. Please download the papers from the links provided below.This course will be conducted in English.

Time: 13:30 - 15:10 on Fridays

Place: National Institute of Genetics, B202 (Library 2nd floor seminar room)

Cource organizer: Yasushi HIROMI Participating faculty

Date Lecturers Topic and paper

Yasushi HIROMI

Cell-cell interactions
Kimble J
Alternations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans.
Dev Biol 87: 286-300, 1981
2009/11/13 Noriyoshi SAKAI
Yasushi HIROMI
Stem cell niche
Yoshida S, Sukeno M, Nabeshima Y
A vasculature-associated niche for undifferentiated spermatogonia in the mouse testis.
Science 317: 1722-1726, 2007
2009/11/20 Tsuyoshi KOIDE
Yasushi HIROMI

Proliferation vs differentiation decision of neural precursors
Chenn A, Walsh CA
Regulation of cerebral cortical size by control of cell cycle exit in neural precursors.
Science 297: 365-369, 2002@

2009/11/27 Toshihiko SHIROISHI
Genomic analysis of transcriptional regulation
Wendt KS, Yoshida K, Itoh T, Bando M, Koch B, Schirghuber E, Tsutsumi S, Nagae G, Ishihara K, Mishiro T, Yahata K, Imamoto F, Aburatani H, Nakao M, Imamoto N, Maeshima K, Shirahige K, Peters JM
Cohesin mediates transcriptional insulation by CCCTC-binding factor.
451: 796-801, 2008
2009/12/18 Ryu UEDA
Yasushi HIROMI

Genomic approach to behavior
Harbison ST, Carbone MA, Ayroles JF, Stone EA, Lyman RF, Mackay TFC
Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep.
Nature Genetics 41, 371-375, 2009

2010/1/8 Akatsuki KIMURA
Yasushi HIROMI

Numerical modeling of pattern formation
Farhadifar R, Roeper J-C, Aigouy B, Eaton S, Juelicher F
The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing.
Current Biology 17: 2095-2104, 2007

2010/1/22 Yumiko SAGA
Yasushi HIROMI
Axis specification in the mouse egg
Hiiragi T, Solter D
First cleavage plane of the mouse egg is not predetermined but defined by the topology of the two apposing pronuclei.
Nature 430:360-364, 2004
note date change!
Tatsumi HIRATA
Yasushi HIROMI
Proposing a mechanism that can explain mysterious (?) results
Feldheim DA, Kim YI, Bergemann AD, Frisen J, Barbacid M, Flanagan JG
Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping.
Neuron 25: 563-74, 2000

The reading list and the course schedule is tentative and is subject to change.
Appropriate grade level and Eligible Departments: (x) 1, (x) 2, (x) 3, (x) 4, (x) 5:
( ) School of Life ScienceC (x) All DepartmentsC( ) Other

To obtain credit one must attend five or more classes (of total of eight classes) . Grades (Pass/Fail) will be determined based on the extent of participation in class.

Developmental Biology II, III, and IV will all be done in the same style, critical reading of the primary literature, covering various topics in developmental biology. Students must read the assigned paper before coming to the class. Active participation in discussion is essential. There will be no overlap in the teaching material that will be used in Developmental Biology II, III, and IV. Taking any one of the three courses will likely give you an idea what development is about. If you wish to specialize in the field of Developmental Biology, we recommend taking all three courses.

Reading lists for the previous years: 2008 2007 2006

For students who are unable to appreciate scientific discussions in English, the course organizer will offer a one-hour discussion session in Japanese for each class. To schedule a discussion session, read the assigned paper and send an email to the course organizer, listing three issues/problems that you would like to discuss. The deadline for scheduling an appointment is 13:30 of the day of the class (Friday). Indicate the time of the day that does not suit you, during the period of Monday following the class to Friday of the next week.

Participating faculty:

name email
Kazuo EMOTO kemoto 5860 C201
Tatsumi HIRATA tathirat 6721 C518
Yasushi HIROMI yhiromi 6767 C415
Takuji IWASATO tiwasato 6773 C408
Akatsuki KIMURA akkimura 5854 A321
Koichi KAWAKAMI kokawaka 6740 C115
Tsuyoshi KOIDE tkoide 5843 X209
Yumiko SAGA ysaga 6829 R221
Noriyoshi SAKAI nosakai 5848 S109
Hiroyuki SASAKI hisasaki 6795 C505
Toshihiko SHIROISHI tshirois 6818 R115
Ryu UEDA rueda 6823 R205


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