Development can be viewed as an integral of
molecular and cell biological events, and also is a process though
which evolutionary changes in form is generated Through discussing how
the principles and concepts of developmental biology developed and what
kind of new challenges they generate, students are expected to nurture
their framework in which they conduct their own work in various
Familiarity with basic concepts of Molecular and Cell Biology is recommended.
This course will introduce basic principles and concepts of that direct developmental phenomena. Various developmental events, such as cell fate determination, cell
differentiation, morphogenesis and animal behavior will be analyzed in
light of gene expression, cell-cell interaction, intracellular
signaling and evolution.
Classes will be run by critical reading of the
primary literature and discussion. It is essential that
you have read the papers before coming to the class. Please
download the papers from the links provided below.This course will be conducted in
Time: 13:30 - 15:10 on Fridays
Place: National Institute of Genetics, B202 (Library 2nd floor seminar room)
|Cource organizer: Yasushi HIROMI
||Topic and paper
Alternations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans.
Dev Biol 87: 286-300, 1981
|| Noriyoshi SAKAI
|Stem cell niche
Yoshida S, Sukeno M, Nabeshima Y
A vasculature-associated niche for undifferentiated spermatogonia in the mouse testis.
Science 317: 1722-1726, 2007
Proliferation vs differentiation decision of neural precursors
Chenn A, Walsh CA
Regulation of cerebral cortical size by control of cell cycle exit in neural precursors.
Science 297: 365-369, 2002@
|Genomic analysis of transcriptional regulation
Wendt KS, Yoshida K, Itoh T, Bando M, Koch B, Schirghuber E, Tsutsumi S, Nagae G, Ishihara K, Mishiro T, Yahata K, Imamoto F, Aburatani H, Nakao M, Imamoto N, Maeshima K, Shirahige K, Peters JM
Cohesin mediates transcriptional insulation by CCCTC-binding factor.
Nature 451: 796-801, 2008
Genomic approach to behavior
Harbison ST, Carbone MA, Ayroles JF, Stone EA, Lyman RF, Mackay TFC
Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep.
Nature Genetics 41, 371-375, 2009
|| Akatsuki KIMURA
Numerical modeling of pattern formation
Farhadifar R, Roeper J-C, Aigouy B, Eaton S, Juelicher F
The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing.
Current Biology 17: 2095-2104, 2007
|Axis specification in the mouse egg
Hiiragi T, Solter D
First cleavage plane of the mouse egg is not predetermined but defined by the topology of the two apposing pronuclei.
Nature 430:360-364, 2004
note date change!
|Proposing a mechanism that can explain mysterious (?) results
Feldheim DA, Kim YI, Bergemann AD, Frisen J, Barbacid M, Flanagan JG
Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping.
Neuron 25: 563-74, 2000
The reading list and the course
schedule is tentative and is subject to change.
|Appropriate grade level and Eligible Departments: (x) 1, (x) 2, (x) 3, (x) 4, (x) 5:
( ) School of Life ScienceC (x) All DepartmentsC( ) Other
To obtain credit one must attend five or more classes (of total of eight classes) . Grades (Pass/Fail) will be determined based on the
extent of participation in class.
Developmental Biology II, III, and IV will all be
done in the same style, critical reading of the primary literature,
covering various topics in developmental biology. Students must read
the assigned paper before coming to the class. Active participation in
discussion is essential. There will be no overlap in the teaching
material that will be used in Developmental Biology II, III, and IV.
Taking any one of the three courses will likely give you an idea what
development is about. If you wish to specialize in the field of
Developmental Biology, we recommend taking all three courses.
Reading lists for the previous years: 2008 2007 2006
For students who are unable to appreciate scientific discussions in
English, the course organizer will offer a one-hour discussion session
in Japanese for each class. To schedule a discussion session, read the
assigned paper and send an email to the course organizer, listing three
issues/problems that you would like to discuss. The deadline for
scheduling an appointment is 13:30 of the day of the class (Friday).
Indicate the time of the day that does not suit you, during the period
of Monday following the class to Friday of the next week.