determination, cell differentiation, morphogenesis and animal behavior will be analyzed in light of gene expression, cell-cell interaction, intracellular signaling and evolution. Classes will be run by critical reading of the primary literature and discussion. It is essential that you have read the papers before coming to the class. Please download the papers from the links provided below.

This course will be run in English. Date/Time: Friday 13:30-15:10 Location: Library 2nd floor seminar room (B201) Course organizer: Yasushi HIROMI (NIG)

Date	Moderator	Content
2007/10/26	Naoyuki FUSE Yasushi HIROMI	Morphogenesis: the Biology of Shape Bertet C, Sulak L, Lecuit T. Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation. Nature 429, 667-67,2004.　　assignment
2007/11/2	Kenta SUMIYAMA Yasushi HIROMI	Homeotic Transformation in Mice Depew Mj, Lufkin T, Rubenstein JLR. Specification of jaw subdivisions by Dlx genes. Science 298, 381-385, 2002　　assignment
2007/11/9	Kotaro KIMURA Yasushi HIROMI	Developmental Regulation by microRNA – The beginning Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75, 843-854, 1993.　　assignment
2007/11/16	Hiroshi SHIMIZU Yasushi HIROMI	Positional Information Strigini M, Cohen SM. Wingless gradient formation in the Drosophila wing. Current Biology 10, 293-300, 2000.
2007/11/30	Tesuji KAKUTANI Yasushi HIROMI	Epigenetic mutations affecting development Jacobsen SE, Meyerowitz EM. Hypermethylated SUPERMAN epigenetic alleles in Arabidopsis Science 277, 1100-1103, 1997 assignment
2007/12/7	Kazuo EMOTO Yasushi HIROMI	Neuronal Polarity de Anda FC, Pollarolo G, Da Silva JS, Camoletto PG, Feiguin F, Dotti CG. Centrosome localization determines neuronal polarity. Nature 436, 704-708, 2005. assignment
2007/12/21	Aya TAKAHASHI Yasushi HIROMI	Stochasticity in Biological Process Delattre M, Felix, AM. Development and evolution of a variable left-right asymmetry in nematodes: the handedness of P11/P12 migration. Developmental Biology 232, 362-371, 2001. assignment
2008/1/18	Akatsuki KIMURA Yasushi HIROMI	Quantitative Modeling / Robustness Barkai N, Leibler S. Robustness in simple biochemical networks. Nature 387, 913-917, 1997. assignment supplement

Papers can be downloaded from NIG IP addresses only. Outside students taking this course who cannot access these papers at their home institution should contact the course organizer (yhiromi(at)lab.nig.ac.jp).

発生生物学IV 2006	Developmental Biology IV 2006
遺伝学専攻の授業	Courses at Dept. Genetics
遺伝学専攻ホームページ	NIG Graduate Program
遺伝研ホームページ	NIG homepage

　 last updated 2007/12/22