In our laboratory, we are interested in understanding about microbial genome evolution and microbial community dynamics, and we are currently reaching out in the following two major research directions; I. Facilitate the development of an integrated database “MicrobeDB.jp”, II. Microbial community dynamics. Our research interests blend a background in microbial genomics and metagenomics with bioinformatics and integrated database developments that are just now allowing the prospect of illuminating microbial community dynamics. We are trying to gain a better understanding of how microbial diversity maintain as well as how it emerged. We are also trying to propose a new evolutionary scenario by recovering DNA information from paleontological remains.
Exploring microbial diversity in a continental serpentinite-hosted hydrothermal system.
Yonezawa, T., Segawa, T., Mori, H., Campos, P.F., Hongoh, Y., Endo, H., Akiyoshi, A., Manabe, M., Kohno, N., Nishida, S., Wu, J., Jin, H., Kishino, H., Kurokawa, K., Yoshifumi, N., Tanabe, H., Mukoyama, H., Yoshida, K., Rasoamiaramanana, A., Yamagishi, S., Hayashi, Y., Yoshida, A., Koike, H., Akishinonomiya, F., Willerslev, E., and Hasegawa, M. (2017). Phylogenomics and morphology of extinct paleognaths reveal the origin and evolution of the ratites. Curr Biol 27, 68-77.
Matsuki, T., Yahagi, K., Mori, H., Matsumoto, H., Hara, T., Tajima, S., Ogawa, E., Kodama, H., Yamamoto, K., Yamada, T., Matsumoto, S., and Kurokawa, K. (2016). A key genetic factor for fucosyllactose utilization affects infant gut microbiota development. Nat Commun 7, 11939.
Okai, S., Usui, F., Yokota, S., Hori-I, Y., Hasegawa, M., Nakamura, T., Okada, S., Yamamoto, K., Nishiyama, E., Mori, H., Yamada, T., Kurokawa, K., Matsumoto, S., Nanno, M., Naito, T., Kato, T., Miyauchi, E., Ohno, H., and Shinkura, R. (2016). High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in mice. Nat Microbiol 1, 16103.