Kuraku Group • Molecular Life History Laboratory

Decoding evolution by understanding the mechanism of genomic readout

Faculty



Research Summary

Our group aims to infer the molecular-level history of complex life, based on molecular phylogenetic approaches to evolutionarily dissecting biodiversity with increasing knowledge of cellular events from genome-wide profiling. We mainly focus on vertebrates including elusive wild species with unique phenotypes. Our interests are categorized into these themes.

1) Elucidating the evolutionary history of genomes by cross-species comparisons
2) Decoding genome evolution mechanisms taking cellular events into account
3) Improving genome-wide data acquisition and analysis methods


The FoxG group of genes analyzed as a proxy of the whole genome. These genes have different retention patterns (A), evolutionary rates of the genes and flanking genomic regions (B and C, respectively), and embryonic expression domains (D, in catshark embryos). Their inter-relationship and its orchestration within a genome remain largely unexplored and belong to our laboratory’s theme.

Selected Publications

Onimaru K, Tatsumi K, Tanegashima C, Kadota M, Nishimura O, Kuraku S. Developmental hourglass and heterochronic shifts in fin and limb development. eLife. 2021 Feb 9;10:e62865. doi: 10.7554/eLife.62865.

Kajikawa E, Horo U, Ide T, Mizuno K, Minegishi K, Hara Y, Ikawa Y, Nishimura H, Uchikawa M, Kiyonari H, Kuraku S, Hamada H. Nodal paralogues underlie distinct mechanisms for visceral left-right asymmetry in reptiles and mammals. Nat Ecol Evol. 2020 Feb;4(2):261-269. doi: 10.1038/s41559-019-1072-2. Epub 2020 Jan 6.

Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K, Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R, Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A, Kuratani S, Sato K, Hyodo S, Kuraku S. Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates. Nat Ecol Evol. 2018 Nov;2(11):1761-1771. doi: 10.1038/s41559-018-0673-5. Epub 2018 Oct 8.

Hara Y, Takeuchi M, Kageyama Y, Tatsumi K, Hibi M, Kiyonari H, Kuraku S. Madagascar ground gecko genome analysis characterizes asymmetric fates of duplicated genes. BMC Biol. 2018 Apr 16;16(1):40. doi: 10.1186/s12915-018-0509-4.


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