Koide Group • Mouse Genomics Resource Laboratory

Behavioral genetics using wild-derived mouse strains


Research Summary

The genetic basis for individual differences in complex traits is still unclear. In order to clarify the mechanisms related to behavioral diversity, we are using a series of wild-derived mouse strains. Wild derived strains exhibit a prominent degree of wildness and phenotypic diversity among them. We are also developing efficient genome editing methodologies in rodents with CRISPR/Cas9. We are identifying genes related to behavioral diversity using these tools, and are aiming to understand the role of these genes in the molecular, cellular, and neural mechanisms that underlie this behavioral diversity.

We applied selective breeding on wild stock of mice and established genetically tamed mice. As a result of genetic analyses, we found a genomic signature of selection on chromosome 11. The region is syntenic to the genomic region which are selected during dog domestication. Currently, we are trying to apply this method to domestication of large rodents used for food in Africa.

Selected Publications

Imai Y, Tanave A, Matsuyama M, Koide T. Efficient genome editing in wild strains of mice using the i-GONAD method. Sci Rep. 2022 Aug 15;12(1):13821.

Matsumura R, Yoshimi K, Sawai Y, Yasumune N, Kajihara K, Maejima T, Koide T, Node K, Akashi M. The role of cell-autonomous circadian oscillation of Cry transcription in circadian rhythm generation. Cell Rep. 2022 Apr 19;39(3):110703.

Matsumoto Y, Nagayama H, Nakaoka H, Toyoda A, Goto T, Koide T. Combined change of behavioral traits for domestication and gene-networks in mice selectively bred for active tameness. Genes Brain Behav. 2021 Mar;20(3):e12721.

Tanave A, Imai Y, Koide T. Nested retrotransposition in the East Asian mouse genome causes the classical nonagouti mutation. Commun Biol. 2019 Aug 2;2:283.

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