Koide Group • Mouse Genomics Resource Laboratory::National Institute of Genetics

Koide Group • Mouse Genomics Resource Laboratory

Behavioral genetics using wild-derived mouse strains

Faculty

KOIDE, Tsuyoshi

Associate Professor

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Research Summary

The genetic basis for individual differences in complex traits is still unclear. In order to clarify the mechanisms related to behavioral diversity, we are using a series of wild-derived mouse strains. Wild derived strains exhibit a prominent degree of wildness and phenotypic diversity among them. We are also developing efficient genome editing methodologies in rodents with CRISPR/Cas9. We are identifying genes related to behavioral diversity using these tools, and are aiming to understand the role of these genes in the molecular, cellular, and neural mechanisms that underlie this behavioral diversity.

We applied selective breeding on wild stock of mice and established genetically tamed mice. As a result of genetic analyses, we found a genomic signature of selection on chromosome 11. The region is syntenic to the genomic region which are selected during dog domestication. Currently, we are trying to apply this method to domestication of large rodents used for food in Africa.

Selected Publications

Takanami K, Kuroiwa M, Ishikawa R, Imai Y, Oishi A, Hashino M, Shimoda Y, Sakamoto H, Koide T. Function of gastrin-releasing peptide receptors in ocular itch transmission in the mouse trigeminal sensory system. Front Mol Neurosci. 2023 Nov 30;16:1280024.

Ono K, Sujino T, Miyamoto K, Harada Y, Kojo S, Yoshimatsu Y, Tanemoto S, Koda Y, Zheng J, Sayama K, Koide T, Teratani T, Mikami Y, Takabayashi K, Nakamoto N, Hosoe N, London M, Ogata H, Mucida D, Taniuchi I, Kanai T. Downregulation of chemokine receptor 9 facilitates CD4⁺CD8αα⁺ intraepithelial lymphocyte development. Nat Commun. 2023 Aug 24;14(1):5152.

Imai Y, Tanave A, Matsuyama M, Koide T. Efficient genome editing in wild strains of mice using the i-GONAD method. Sci Rep. 2022 Aug 15;12(1):13821.

Matsumura R, Yoshimi K, Sawai Y, Yasumune N, Kajihara K, Maejima T, Koide T, Node K, Akashi M. The role of cell-autonomous circadian oscillation of Cry transcription in circadian rhythm generation. Cell Rep. 2022 Apr 19;39(3):110703.