Cells are a beautiful example of architecture made by the nature. How such harmonious architecture is constructed ‘without an architect’ remains a mystery. This laboratory is studying the mechanisms underlying the movement and positioning of intracellular organelles (such as the cell nucleus) at appropriate positions with appropriate sizes, using approaches involving quantitative microscopy and structural calculations of cells. Through our studies, we aim to understand the secrets of constructing the cell.
Cell division at the 1-cell stage (left) and cell arrangement pattern during development (right) in the C. elegans embryo. The upper panels show actual C. elegans embryos and the lower panels show our quantitative simulations. (The lower right visualization was obtained using software developed by Dr. A. Funahashi [Keio Univ].)
Torisawa T, Kimura A. The generation of dynein networks by multi-layered regulation and their implication in cell division. Front Cell Dev Biol. 2020 Jan 31; 8:22.
Kondo T, Kimura A. Choice between 1- and 2-furrow cytokinesis in Caenorhabditis elegans embryos with tripolar spindles. Mol Biol Cell. 2019 Jul 22;30(16):2065-2075.
Kimura K, Mamane A, Sasaki T, Sato K, Takagi J, Niwayama R, Hufnagel L, Shimamoto Y, Joanny JF, Uchida S, Kimura A. Endoplasmic-reticulum-mediated microtubule alignment governs cytoplasmic streaming. Nat Cell Biol. 2017 Apr;19(4):399-406.