Inoue Group • Human Genetics Laboratory

Genomic medicine and evolutionary studies with next generation sequencing technology


INOUE, Ituro

Project Professor


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Project Assistant Professor


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Research Summary

Our research goal is to elucidate disease causalities and their patho-mechanisms, and ultimately to develop therapeutic tool. With the advent of next generation sequencing technologies, it becomes very handy to identify causalities of monogenic diseases as well as complex diseases. With the vast of genomic information at hand, we will combine gene expression profiles of the responsible tissues together with clinical information to understand the global picture of diseases.

We generated metagenomic sequencing data from the DNA samples extracted from the dental pulp of Jomon individuals, who lived in Japan more than 3000 years ago. Eleven putative ancient viral genomes were identified. Among them, we reconstructed the complete genomic sequence of the Siphovirus contig89, which resides in the human oral cavity.

Selected Publications

Revathidevi S, Hosomichi K, Natsume T, Nakaoka H, Fujito NT, Akatsuka H, Sato T, Munirajan AK, Inoue I. AMBRA1 p.Gln30Arg Mutation, Identified in a Cowden Syndrome Family, Exhibits Hyperproliferative Potential in hTERT-RPE1 Cells. Int J Mol Sci. 2022 Sep 22;23(19):11124.

Sugimoto R, Nishimura L, Nguyen PT, Inoue I. Extraction of CRISPR-targeted sequences from the metagenome. STAR Protoc. 2022 Sep 16;3(3):101525.

Yoshioka A, Nakaoka H, Fukumoto T, Inoue I, Nishigori C, Kunisada M. The landscape of genetic alterations of UVB-induced skin tumors in DNA repair-deficient mice. Exp Dermatol. 2022 Oct;31(10):1607-1617.

Yamaguchi M, Nakaoka H, Suda K, Yoshihara K, Ishiguro T, Yachida N, Saito K, Ueda H, Sugino K, Mori Y, Yamawaki K, Tamura R, Revathidevi S, Motoyama T, Tainaka K, Verhaak RGW, Inoue I, Enomoto T. Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium. Nat Commun. 2022 Feb 17;13(1):943.

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