Genomic medicine and evolutionary studies with next generation sequencing technology

Faculty

INOUE, Ituro

Project Professor

 

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FUJITO, Naoko

Project Assistant Professor

 

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Research Summary

Our research goal is to elucidate disease causalities and their patho-mechanisms, and ultimately to develop therapeutic tool. With the advent of next generation sequencing technologies, it becomes very handy to identify causalities of monogenic diseases as well as complex diseases. With the vast of genomic information at hand, we will combine gene expression profiles of the responsible tissues together with clinical information to understand the global picture of diseases.

Selected Publications

Revathidevi S, Hosomichi K, Natsume T, Nakaoka H, Fujito NT, Akatsuka H, Sato T, Munirajan AK, Inoue I. AMBRA1 p.Gln30Arg Mutation, Identified in a Cowden Syndrome Family, Exhibits Hyperproliferative Potential in hTERT-RPE1 Cells. Int J Mol Sci. 2022 Sep 22;23(19):11124.

Sugimoto R, Nishimura L, Nguyen PT, Inoue I. Extraction of CRISPR-targeted sequences from the metagenome. STAR Protoc. 2022 Sep 16;3(3):101525.

Yoshioka A, Nakaoka H, Fukumoto T, Inoue I, Nishigori C, Kunisada M. The landscape of genetic alterations of UVB-induced skin tumors in DNA repair-deficient mice. Exp Dermatol. 2022 Oct;31(10):1607-1617.

Yamaguchi M, Nakaoka H, Suda K, Yoshihara K, Ishiguro T, Yachida N, Saito K, Ueda H, Sugino K, Mori Y, Yamawaki K, Tamura R, Revathidevi S, Motoyama T, Tainaka K, Verhaak RGW, Inoue I, Enomoto T. Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium. Nat Commun. 2022 Feb 17;13(1):943.