We study the evolutionary process for acquisition of novel phenotypic characters by comparative genomics and molecular evolutionary approaches, using various materials such as animals, fungi, or bacteria. Particularly, we have recently focused more on (1) Molecular evolutionary analysis of genes associated with sensory organs, (2) Evolution of septal pore cap in fungi, (3) Biodiversity and dynamics of marine microbes based on metagenomic analysis, (4) Molecular phylogeny based on mitochondrial and nuclear genes, (5) Study of disease causal gene and gene model of disease, (6) Knowledge finding and system development for big data in life science.
Molecular phylogeny of cnidarian opsin genes. We found that cnidarian opsin genes are divided into three groups and evolved independently in each lineages (class/subclass).
Kinjo, S., Kiyomoto, M., Yamamoto, T., Ikeo, K., and Yaguchi, S. HpBase: a genome database of a sea urchin, Hemicentrotus pulcherrimus. Development, Growth & Differentiation. in press.
Hashimoto, S., Tabuchi, Y., Yurino, H., Hirohashi, Y., Deshimaru, S., Asano, T., Mariya, T., Oshima, K., Takamura, Y., Ukita, Y., Ametani, A., Kondo, N., Monma, N., Takeda, T., Misu, S., Okayama, T., Ikeo, K., Saito, T., Kaneko, S., Suzuki, Y., Hattori, M., Matsushima, K., and Torigoe, T. (2017). Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues. Sci Rep 7, 14225.
Gojobori, T., Ikeo, K., Katayama, Y., Kawabata, T., Kinjo, A.R., Kinoshita, K., Kwon, Y., Migita, O., Mizutani, H., Muraoka, M., Nagata, K., Omori, S., Sugawara, H., Yamada, D., and Yura, K. (2016). VaProS: a database-integration approach for protein/genome information retrieval. J Struct Funct Genomics 17, 69-81.