Mechanism that regulates an efficient switch from cell elongation to cell division.

Division-site localization of RodZ is required for efficient Z ring formation in Escherichia coli

Yusuke Yoshii, Hironori Niki, Daisuke Shiomi

Molecular Microbiology 2019 DOI:10.1111/mmi.14217

Cell elongation and cell division are controlled by different complexes. The mechanisms that promotes a switch from elongation to division have been still unclear. It has been recently reported that a direct interaction between MreB actin, which regulates elongation, and FtsZ tubulin, which regulates division, promotes the switching at the division site. We have analyzed RodZ that interacts with MreB. In this paper, we found that RodZ also localized on the division site depending on FtsZ, and that MreB localized to the division site depending on RodZ. When RodZ is not localized to the division site, the formation of the division ring (Z ring) composed of FtsZ was delayed. The localization of RodZ to the division site promotes the division ring formation and efficient cell division. This work was supported by KAKENHI and NIG-JOINT A.

Figure1

Figure: Division site localization of RodZ promotes an efficient formation of Z ring (i.e. switch from elongation to division).


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