Comparative Genomics Laboratory • Toyoda Group

Comparative genomics through ultra-large scale sequencing


Research Summary

The Comparative Genomics Laboratory was established in April 2008 with the task to understand basic rules of biological systems based on actively reading and analyzing various genomes of interest using cutting-edge DNA sequencing and analysis technology. Currently, we are analyzing personalized genomes of primates in addition to the organisms those living in the extreme environmental conditions. The figures in the left column show examples of such activities.

Picture of the animals whose genomes have been analyzed


Takehana, Y., Matsuda, M., Myosho, T., Suster, M.L., Kawakami, K., Shin-I, T., Kohara, Y., Kuroki, Y., Toyoda, A., Fujiyama, A., Hamaguchi, S., Sakaizumi, M., and Naruse, K. (2014). Co-option of Sox3 as the male-determining factor on the Y chromosome in the fish Oryzias dancena. Nat Commun 5, 4157.

Nikaido, M., Noguchi, H., Nishihara, H., Toyoda, A., Suzuki, Y., Rei Kajitani, R., Suzuki, H., Okuno, M., Aibara, M., Ngatunga, B.P., Mzighani, S.I., Kalombo, H.W.J., Masengi, K.W.A., Tuda, J., Nogami, S., Maeda, R., Iwata,M., Abe, Y., Fujimura, K., Okabe, M., Amano, T., Maeno, A., Shiroishi, T., Itoh, T., Sugano, S., Kohara, Y., Fujiyama, A., and Okada, N. (2013). Coelacanth genomes reveal signatures for evolutionary transition from water to land. Genome Research 23, 1740-1748.

Huang, X., Kurata, N., Wei, X., Wang, Z.X., Wang, A., Zhao, Q., Zhao, Y., Liu, K., Lu, H., Li, W., Guo, Y., Lu, Y., Zhou, C., Fan, D., Weng, Q., Zhu, C., Huang, T., Zhang, L., Wang, Y., Feng, L., Furuumi, H., Kubo, T., Miyabayashi, T., Yuan, X., Xu, Q., Dong, G., Zhan, Q., Li, C., Fujiyama, A., Toyoda, A., Lu, T., Feng, Q., Qian, Q., Li, J., and Han, B. (2012). A map of rice genome variation reveals the origin of cultivated rice. Nature 490, 497-501.