Organisms inhabit various environments and exhibit remarkable genome diversity. Our main research goal is to understand the relationships between genome diversity and habitat diversity. Currently, we are focusing on microbes. We use various bioinformatics and statistical methodologies related to comparative genomics and metagenomics for our research. We are also developing some bioinformatics methods and tools for genomics and metagenomics, and applying these methods for various collaborative researches in the Advanced Genomics Center.
(A) VITCOMIC2: Visualization tool for the phylogenetic composition of microbial communities. (left)
(B) A VITCOMIC2 visualization example of a microbial community sequence data. (right)
Yonezawa T, Segawa T, Mori H, Campos PF, Hongoh Y, Endo H, Akiyoshi A, Kohno N, Nishida S, Wu J, Jin H, Adachi J, Kishino H, Kurokawa K, Nogi Y, Tanabe H, Mukoyama H, Yoshida K, Rasoamiaramanana A, Yamagishi S, Hayashi Y, Yoshida A, Koike H, Akishinonomiya F, Willerslev E, Hasegawa M. Phylogenomics and Morphology of Extinct Paleognaths Reveal the Origin and Evolution of the Ratites. Curr Biol. 2017 Jan 9;27(1):68-77.
Mori H, Maruyama T, Yano M, Yamada T, Kurokawa K. VITCOMIC2: visualization tool for the phylogenetic composition of microbial communities based on 16S rRNA gene amplicons and metagenomic shotgun sequencing. BMC Syst Biol. 2018 Mar 19;12(Suppl 2):30.
Segawa T, Matsuzaki R, Takeuchi N, Akiyoshi A, Navarro F, Sugiyama S, Yonezawa T, Mori H. Bipolar dispersal of red-snow algae. Nat Commun. 2018 Aug 6;9(1):3094.
Kosakamoto H, Yamauchi T, Akuzawa-Tokita Y, Nishimura K, Soga T, Murakami T, Mori H, Yamamoto K, Miyazaki R, Koto A, Miura M, Obata F. Local Necrotic Cells Trigger Systemic Immune Activation via Gut Microbiome Dysbiosis in Drosophila. Cell Rep. 2020 Jul 21;32(3):107938.