開催日：2026/05/25
時間：14:00-15:00
場所：図書館3階セミナー室
演者：Silvana Gaudieri
演題：The impact of viral adaptation to the host’s immune response on infection outcome
要旨：The host’s anti-viral immune response is a major predictor of infection
outcome. This anti-viral response is, in part, governed by a set of
interconnected highly variable receptor-ligand pairs that are formed at both
the germline and somatic level. The variation exhibited by these host
molecules reflects the selection pressure likely exerted by pathogens
through thousands of generations. However, highly mutable RNA viruses
such as human immunodeficiency virus (HIV) can evade these host
immune responses, and such viral variations (adaptations) are a major
impediment to long-lasting and effective vaccines. Understanding the
complexity of the host-viral interaction is critical to immunogen design.
We have utilised high-resolution genetic and cellular approaches on
samples from rare cohorts of HIV-infected individuals to determine how
variation in the host and the virus can impact their interaction at the single
cell level. Genetic data from thousands of viral strains, host genotypes and
single cell transcriptomes highlight the multiple layers of our anti-viral
immune response but also the various adaptation mechanisms utilised by
viruses to enable them to continue to be global health issues.
司会：Kazuho Ikeo
言語：英語
連絡先：Kazuho Ikeo