Developmental Biology III (2014) Syllabus
発生生物学 III (2014) シラバス




Course objectives:
Development can be viewed as an integral of molecular and cell biological events, and also is a process though which evolutionary changes in form is generated. Through discussing how the principles and concepts of developmental biology developed and what kind of new challenges they generate, students are expected to nurture their framework in which they conduct their own work in various disciplines.

発生現象は分子細胞学的現象が「積分」されたものと捉えることができます.また,発生過程は形態変化の進化がおこる場所でもあります.この授業では,発生生物学の様々な原理や概念がどのようにして生まれ,どのような新たな問題を生み出すかを議論することを通じ,各自が自分の分野での研究の枠組みを作るのに役立ててもらうことを目指しています.

Prerequisites:
Familiarity with basic concepts of Molecular and Cell Biology is recommended.
分子細胞生物学の基礎的知識があるとより楽しめるでしょう.

Contents:
This course will introduce basic principles and concepts of that direct developmental phenomena. Various developmental events, such as cell fate determination, cell differentiation, morphogenesis and animal behavior will be analyzed in light of gene expression, cell-cell interaction, intracellular signaling and evolution.
この授業では個体発生を指令する様々な基本原理や概念をとりあげます.細胞運命決定,細胞分化,形態変化,行動等のイベントについて,遺伝子発現,細胞間相互作用,シグナル伝達や進化等の観点から分析します.

Classes will be run by critical reading of the primary literature and discussion. Please download the paper from links below and take a look at it in advance. It is not necessary to have completely understood the paper before coming to class.
この授業は「原著論文を読んで議論する」という形式で行います.前持って論文を以下のリンクからダウンロードし,目を通しておいてください.完全に理解する必要はありません.

This course will be conducted in English. For questions and coments in Japanese, lecturers will provide simultaneous translation service to English.
この授業は英語で行いますが,日本語での質問やコメントに対しては講師が同時通訳サービスを提供します.

Time: 13:30 - 15:10 on Mondays 月曜13:30-15:10

Place: National Institute of Genetics, B202 (Library 2nd floor seminar room) 遺伝研B202(図書館2階)
This course is also offered as a part of the "Integrated Brain Science I, II" of the SOKENDAI Brain Science Joint Project.
People in other departments/institutions can participate in this class using the remote lecture system.
この授業は脳科学専攻間融合プログラム統合脳科学I,IIの一部としても履修できます.他専攻の方は遠隔講義システムで受講できます.

Cource organizer: Yumiko Saga 相賀 裕美子 Participating faculty 担当教員リスト
Schedule:

Date Lecturers Topic and paper
2014/10/20
Hitoshi SAWA

Cell-cell interaction and asymmetric division
Goldstein B.
Induction of gut in Caenorhabditis elegans embryos.
Nature. 1992 May 21;357(6375):255-7.

Before you read this paper
2014/10/27
Rieko AJIMA

Morphogen and patterning
Robert D. Riddle, Randy L. Johnson, Ed Laufer, and Cliff Tabin
Sonic hedgehog Mediates the Polarizing Activity of the ZPA
Cell, Vol. 75, 1401-1416, December 31, 1993

Before you read this paper
2014/11/10
Hiromi HIRATA

Reprogramming
Gurdon JB.
The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles.
J Embryol Exp Morphol. 1962 Dec;10:622-40.
Campbell KH, McWhir J, Ritchie WA and Wilmut I.
Sheep cloned by nuclear transfer from a cultured cell line.
Nature. 1996 Mar 7; 380 (6569): 64-6.

Before you read this paper
2014/11/17
Yoichiro TAMORI

Organ growth control
Moreno E., Basler, K., Morata, G.
Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development.
Nature 416: 755-759, 2002.

Before you read this paper
2014/12/8 Takanori AMANO

Evolution of gene regulation
Schmidt D, Schwalie PC, Wilson MD, Ballester B, Goncalves A et al.
Five-Vertebrate ChIP-seq Reveals the Evolutionary Dynamics of Transcription Factor Binding
Science 328: 1036-1040, 2010.

Before you read this paper
2015/1/19
Yumiko SAGA

Neural Crest Pasticity
Trainor P, Krumlauf R.
Plasticity in mouse neural crest cells reveals a new patterning role for cranial mesoderm.
Nat Cell Biol. 2000 Feb;2(2):96-102.

Before you read this paper
2015/1/26

Takuji IWASATO

Development of the Cerebral Cortex
von Melchner L1, Pallas SL, Sur M
Visual behaviour mediated by retinal projections directed to the auditory pathway.
Nature. 2000 Apr 20;404(6780):871-6.

Before you read this paper
2015/2/2
Tsuyoshi KOIDE

Interplay between behavior and myelination
Makinodan, M., Rosen, K.M., Corfas, G.
A critical period for social experience-dependent oligodendrocyte maturation and myelination
Science 337, 1357-1360, 2012

Before you read this paper

The reading list and the course schedule is tentative and is subject to change.
使用する論文は変更される可能性があります.
Appropriate grade level and Eligible Departments: (x) 1, (x) 2, (x) 3, (x) 4, (x) 5:
( ) School of Life Science, (x) All Departments,( ) Other

Grades:
To obtain credit one must attend five or more classes (of total of eight classes) . Grades (A, B, C, D) will be determined based on the extent of participation in class.
単位取得には8セッションのうち5つ以上に出席する必要があります.成績(A,B,C,D)はクラスへの参加の程度によって判定します.

Notes:
Developmental Biology II-IV is a discussion-based course involving critical reading of the primary literature. Each year, one of the three courses (Developmental Biology II, III, or IV) will be offered, with no overlap in the material used. Taking any one of the three courses will likely give you an idea what development is about. If you wish to specialize in the field of Developmental Biology, we recommend taking all three courses.
発生生物学II-IVは原著論文をネタに議論する形式で行います.毎年3つの科目のどれか(発生生物学II, IIIまたはIV)が開講され,これら3科目での使用論文の重複はありません.どの科目を履修しても発生生物学の「味見」はできるでしょう.自分で発生研究を志しているなら3科目全てを聞いてみることをお勧めします.

Reading lists for the previous years: 2013 2012 2011 2010 2009 2008 2007 2006

 

Other courses in developmental biology

Developmental Biology I (e-learning course, in Japanese)

Developmental Biology (offered in the Department of Basic Biology)

Reproductive Biology (offered in the Department of Basic Biology)



Participating faculty:

name email
(xxxx[at]nig.ac.jp)
phone
(055-981-xxxx)
office
Yumiko SAGA 相賀 裕美子 ysaga 6829 R221

Hitoshi SAWA  澤 斉

hisawa

6845

G307

Rieko AJIMA  安島 理恵子

rajima

6832

R219

Hiromi HIRATA  平田 普三

hihirata

5825

C214

Yoichiro TAMORI  田守 洋一郎

yotamori

6813

G403

Tsuyoshi KOIDE 小出 剛

tkoide

5843

X209

Takanori AMANO 天野 孝紀

tamano

6820

R117

Takuji IWASATO 岩里 琢治

tiwasato

6773

C408

 


last updated 141119