Course objectives:
Development can be viewed as an integral of
molecular and cell biological events, and also is a process though
which evolutionary changes in form is generated. Through discussing how
the principles and concepts of developmental biology developed and what
kind of new challenges they generate, students are expected to nurture
their framework in which they conduct their own work in various
disciplines.
発生現象は分子細胞学的現象が「積分」されたものと捉えることができます.また,発生過程は形態変化の進化がおこる場所でもあります.この授業では,発生生物学の様々な原理や概念がどのようにして生まれ,どのような新たな問題を生み出すかを議論することを通じ,各自が自分の分野での研究の枠組みを作るのに役立ててもらうことを目指しています.
Prerequisites:
Familiarity with basic concepts of Molecular and Cell Biology is recommended.
分子細胞生物学の基礎的知識があるとより楽しめるでしょう.
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Contents:
This course will introduce basic principles and concepts of that direct
developmental phenomena. Various developmental events, such as cell fate
determination, cell
differentiation, morphogenesis and animal behavior will be analyzed in
light of gene expression, cell-cell interaction, intracellular
signaling and evolution.
この授業では個体発生を指令する様々な基本原理や概念をとりあげます.細胞運命決定,細胞分化,形態変化,行動等のイベントについて,遺伝子発現,細胞間相互作用,シグナル伝達や進化等の観点から分析します.
Classes will be run by critical reading of the
primary literature and discussion. Please download the paper from links below and take a look at it in advance. It is not necessary to have completely understood the paper before coming to class.
この授業は「原著論文を読んで議論する」という形式で行います.前持って論文を以下のリンクからダウンロードし,目を通しておいてください.完全に理解する必要はありません.
This course will be conducted in English. For questions and coments in Japanese, lecturers will provide simultaneous translation service to English.
この授業は英語で行いますが,日本語での質問やコメントに対しては講師が同時通訳サービスを提供します. |
Schedule:
Date |
Lecturers |
Topic and paper |
2013/10/21
|
Tatsumi HIRATA
Yasushi HIROMI
|
Developmental genetics
Tan JC, Nocka K, Ray P, Traktman P, Besmer P
The dominant W42 spotting phenotype results from a missense mutation in the c-kit receptor kinase.
Science 247: 209-212, 1990
Before you read this paper |
2013/10/28
|
Yuzuru KATO
Yasushi HIROMI |
Dosage compensation
Xu N, Tsai C-L, Lee JT
Transient Homologous Chromosome Pairing Marks the Onset of X Inactivation.
Science 311: 114-152, 2006
Before you read this paper
|
2013/11/11
|
Noriyoshi SAKAI
Yasushi HIROMI
note schedule change |
Germ cell plasticity
Kanatsu-Shinohara M, Inoue K, Lee J, Yoshimoto M, Ogonuki N, Miki H, Baba S, Kato T, Kazuki Y, Toyokuni S, Toyoshima M, Niwa O, Oshimura M, Heike T, Nakahata T, Ishino F, Ogura A, Shinohara T
Generation of pluripotent stem cells from neonatal mouse.
Cell 119: 1001-1012, 2004
Before you read this paper
|
2013/11/18
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Toshihiko SHIROISHI
Yasushi HIROMI
note schedule change |
Identification of cis-regulatry sequences from large genome data
Shen Y, Yue F, McCleary DF, Ye Z, Edsall L, Kuan S, Wagner U, Dixon J, Lee L, Lobanenkov VV, Ren B
A map of the cis-regulatory sequences in the mouse genome.
Nature 488: 116-120, 2012
Before you read this paper |
2013/11/25
|
Shinji IHARA
Yasushi HIROMI |
Cell fusion
Mohler WA, Shemer G, del Campo JJ, Valansi C, Opoku-Serebuoh E, Scranton V, Assaf N, White JG, Podbilewicz B
The Type I membrane protein EFF-1 Is essential for developmental cell fusion.
Developmental Cell 2: 355-362, 2002
Before you read this paper
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2013/12/16
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Ryu UEDA
Yasushi HIROMI |
Pattern formation/Compartmentalisation
Garcia-Bellido A, Ripoll A, Morata G.
Developmental Compartmentalisation of the Wing Disk of Drosophila.
Nature New Biology 245, 251-253, 1973
Before you read this paper |
2014/1/20
|
Hidenobu MIZUNO
Yasushi HIROMI |
Cellular mechanisms of memory storage
Martin KC, Casadio A, Zhu H, Yaping E, Rose JC, Chen M, Bailey CH, Kandel ER.
Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage.
Cell 91: 927-938, 1997
Before you read this paper
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2014/3/31 |
Yasushi HIROMI
Yumiko SAGA
note schedule change |
Mysterious phenotypes
Hiromi Y, Mlodzik M, West SR Rubin GM, Goodman CS
Ectopic expression of seven-up produces cell fate changes during ommatidial assembly.
Development 118: 1123-1135, 1993
Before you read this paper |
The reading list and the course schedule is tentative and is subject to change.
使用する論文は変更される可能性があります. |
Grades:
To obtain credit one must attend five or more classes (of total of eight classes) . Grades (A, B, C, D) will be determined based on the extent of participation in class.
単位取得には8セッションのうち5つ以上に出席する必要があります.成績(A,B,C,D)はクラスへの参加の程度によって判定します.
Notes:
Developmental Biology II-IV is a discussion-based course involving critical reading of the primary literature. Each year, one of the three courses (Developmental Biology II, III, or IV) will be offered, with no overlap in the
material used.
Taking any one of the three courses will likely give you an idea what
development is about. If you wish to specialize in the field of
Developmental Biology, we recommend taking all three courses.
発生生物学II-IVは原著論文をネタに議論する形式で行います.毎年3つの科目のどれか(発生生物学II, IIIまたはIV)が開講され,これら3科目での使用論文の重複はありません.どの科目を履修しても発生生物学の「味見」はできるでしょう.自分で発生研究を志しているなら3科目全てを聞いてみることをお勧めします.
Reading lists for the previous years: 2012 2011 2010 2009 2008 2007 2006
Other courses in developmental biology
Developmental Biology I (e-learning course, in Japanese)
Developmental Biology (offered in the Department of Basic Biology)
Reproductive Biology (offered in the Department of Basic Biology)
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