Course objectives:
Development can be viewed as an integral of
molecular and cell biological events, and also is a process though
which evolutionary changes in form is generated Through discussing how
the principles and concepts of developmental biology developed and what
kind of new challenges they generate, students are expected to nurture
their framework in which they conduct their own work in various
disciplines.
Prerequisites:
Familiarity with basic concepts of Molecular and Cell Biology is recommended. |
Contents:
This course will introduce basic principles and concepts of that direct
developmental phenomena. Various developmental events, such as cell fate
determination, cell
differentiation, morphogenesis and animal behavior will be analyzed in
light of gene expression, cell-cell interaction, intracellular
signaling and evolution.
Classes will be run by critical reading of the
primary literature and discussion. Please download the paper from links below and take a look at it in advance. It is not necessary to have completely understood the paper before coming to class.
This course will be conducted in English. |
Time: 13:30 - 15:10 on Mondays (except for 4 sessions in November, when the class will be held in 15:20-17:00)
Place: National Institute of Genetics, B202 (Library 2nd floor seminar room)
This course is also offered as a part of the "Integrated Brain Science I, II" of the SOKENDAI Brain Science Joint Project.
People in other departments/institutions can participate in this class using the remote lecture system.
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Cource organizer: Yasushi HIROMI |
Participating faculty |
Schedule:
Date |
Lecturers |
Topic and paper |
2012/10/22
13:30-15:10 |
Yasushi HIROMI
Saori MIYAZAKI |
Cellular autonomy
Hake S and Freeling M
Analysis of genetic mosaics show that the extra epidermal cell divisions in Knotted mutant maize plants are induced by adjacent mesophiyll cells.
Nature 320: 621-623, 1986
How to obtain this paper
Introduction to the paper
|
2012/11/5
15:20-17:00 |
Ichiro HIRATANI
Yasushi HIROMI |
Cell cycle regulation
Newport JW, Kirschner MW
Regulation of the cell cycle during early Xenopus development.
Cell 37: 731-742, 1984
Before you read this paper |
2012/11/12
15:20-17:00 |
Hitoshi SAWA
Yasushi HIROMI |
Cell-cell signaling
Sternberg PW, Horvitz HR
Pattern formation during vulval development in C. elegans.
Cell 44: 761-772, 1986
Before you read this paper |
2012/11/19
15:20-17:00 |
Hiromi HIRATA
Yasushi HIROMI |
Reprogramming of cell fates
Davis RL, Weintraub H, Lassar AB
Expression of a single transfected cDNA converts fibroblasts to myoblasts.
Cell 51: 987-1000, 1987
Before you read this paper |
2012/11/26
15:20-17:00 |
Yumiko SAGA
Yasushi HIROMI |
Symmetry breaking of the embryo
Nonaka S, Shiratori H, Saijoh Y, Hamada H
Determ ination of left|right patterning of the mouse embryo by artificial nodal flow
Nature 418:96-99, 2002
Before you read this paper |
2012/12/3
13:30-15:10 |
Tsuyoshi KOIDE
Yasushi HIROMI |
Epigenetic reprogramming in cloned embryos
Dean W, Santos F, Stojkovic M, Zakhartchenko V, Walter J, Wolf E, Reik W
Conservation of methylation reprogramming in mammalian development: Aberrant reprogramming in cloned embryos.
PNAS 98: 13734-13738, 2001
Before you read this paper |
2013/1/7
13:30-15:10 |
Takuji IWASATO
Yasushi HIROMI |
Activity-dependent development of neuronal circuits
Stellwagen D, Shatz CJ
An instructive role for retinal waves in the development of retinogeniculate connectivity
Neuron 33: 357-367, 2002
Before you read this paper |
2013/1/21
13:30-15:10
|
Shu KONDO
Yasushi HIROMI |
Neurogenetic dissection of memory
McGuire SE, Le PT, Osborn AJ, Matsumoto K, Davis RL
Spatiotemporal rescue of memory dysfunction in Drosophila.
Science 302:1765-1768, 2003
Before you read this paper |
The reading list and the course schedule is tentative and is subject to change. |
Appropriate grade level and Eligible Departments: (x) 1, (x) 2, (x) 3, (x) 4, (x) 5:
( ) School of Life ScienceC (x) All DepartmentsC( ) Other |
Grades:
To obtain credit one must attend five or more classes (of total of eight classes) . Grades (A, B, C, D) will be determined based on the extent of participation in class.
Notes:
Developmental Biology II-IV is a discussion-based course involving critical reading of the primary literature. Each year, one of the three courses (Developmental Biology II, III, or IV) will be offered, with no overlap in the
material used.
Taking any one of the three courses will likely give you an idea what
development is about. If you wish to specialize in the field of
Developmental Biology, we recommend taking all three courses.
Reading lists for the previous years: 2011 2010 2009 2008 2007 2006
Other courses in developmental biology
Developmental Biology I (e-learning course, in Japanese)
Developmental Biology (offered in the Department of Basic Biology)
Reproductive Biology (offered in the Department of Basic Biology)
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