November 4, 2011
Morphogen gradient
Gregor T, McGregor AP, Bialek, Wieschaus E
Stability and nuclear dynamics of the Bicoid morphogen gradient.
Cell 130: 141-152, 2007
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In this class, we will study the issues about gMorphogen Gradienth, being one of the most classical and important concepts in developmental biology.
Selected paper is;
Stability and Nuclear Dynamics of the Bicoid Morphogen Gradient
Gregor etal., Cell(2007)
http://www.cell.com/abstract/S0092-8674(07)00663-0
This is an unique study in that it poses a doubt for widely believed mechanisms in the formation of bicoid gradient by showing the diffusion dynamics of Bicoid protein. Based on their findings and the historical knowledge about gBicoidh, we will make a free discussion by asking what is the big question and how to solve it. We do not go deep into the mathematical model, so it is not necessary to fully understand the paper. Instead attendees are recommended to pre-study the basics about gBicoidh by referring a textbook for developmental biology or visiting the following link providing a free lecture by Eric Wieschaus (Bicoidfs story starts around 13:40 of 28:30 movie).
http://www.youtube.com/user/ibioseminars?feature=mhee#p/search/0/Ncxs21KEj0g
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