Course description :
Various developmental events, such as cell fate determination, cell differentiation, morphogenesis and animal behavior will be analyzed in light of gene expression, cell-cell interaction, intracellular signaling and evolution. Classes will be run by critical reading of the primary literature and discussion.
科目の概要:
細胞運命決定、細胞分化、形態形成や個体の行動制御等の個体発生の様々な現象を、遺伝子発現調節、細胞間相互作用、細胞内情報伝達等の分子機構や進化の視点から議論し、論文講読とディスカッションを通した演習を行う。（講義）
Course purpose:
Development can be viewed as an integral of molecular and cell biological events, and also is a process though which evolutionary changes in form is generated. Through discussing how the principles and concepts of developmental biology developed and what kind of new challenges they generate, students are expected to nurture their framework in which they conduct their own work in various disciplines.
科目の目的 :
発生現象は分子細胞学的現象が「積分」されたものと捉えることができます。また、発生過程は形態変化の進化がおこる場所でもあります。この授業では、発生生物学の様々な原理や概念がどのようにして生まれ、どのような新たな問題を生み出すかを議論することを通じ、各自が自分の分野での研究の枠組みを作るのに役立ててもらうことを目指しています。
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Contents:
This course will introduce basic principles and concepts of that direct developmental phenomena. Various developmental events, such as cell fate determination, cell differentiation, morphogenesis and animal behavior will be analyzed in light of gene expression, cell-cell interaction, intracellular signaling and evolution. Classes will be run by critical reading of the primary literature and discussion. Please download the paper from links below and take a look at it in advance. It is not necessary to have completely understood the paper before coming to class. This course will be conducted in English. For questions and comments in Japanese, lecturers will provide simultaneous translation service to English.
授業内容:
授業計画：この授業では個体発生を指令する様々な基本原理や概念をとりあげます。細胞運命決定、細胞分化、形態変化、行動等のイベントについて、遺伝子発現、細胞間相互作用、シグナル伝達や進化等の観点から分析します。この授業は「原著論文を読んで議論する」という形式で行います。前持って論文を以下のリンクからダウンロードし、目を通しておいてください。完全に理解する必要はありません。この授業は英語で行いますが、日本語での質問やコメントに対しては講師が同時通訳サービスを提供します。 |
Time: 13:30 - 15:10 on Mondays 月曜13:30-15:10
Place: National Institute of Genetics, B202 (Library 2nd floor seminar room) 遺伝研B202(図書館２階）
This course is also offered as a part of the Integrative Bioscience Education Program.
People in other departments/institutions can participate in this class using the remote lecture system.
この授業は統合生命科学教育プログラムの一部としても履修できます．他専攻の方は遠隔講義システムで受講できます．
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| Cource organizer: Yumiko Saga 相賀 裕美子 |
Participating faculty 担当教員リスト |
Schedule:
| Date |
Lecturers |
Topic and paper |
2018/11/ 5
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Hitoshi SAWA 澤 |
Cell-cell interaction and asymmetric cell division
Induction of gut in Caenorhabditis elegans embryos.
Goldstein B.
Nature. 1992 May 21;357(6375):255-7.
Before you read this paper
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2018/11/12
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Katsutoshi TSUDA 津田
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Tuning crop traits by editing developmental genes
Engineering Quantitative Trait Variation for Crop Improvement by Genome Editing
Daniel Rodriguez-Leal, Zachary H. Lemmon, Jarrett Man, Madelaine E. Bartlett, Zachary B. Lippman
Volume 171, Issue 2, 5 October 2017, Pages 470-480.e8
Before you read this paper
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2018/11/19
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Kuniaki SAITO 齋藤 都暁 |
Epigenetic control of developmental genes
DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development
Masaki Okano, Daphne W. Bell, Daniel A. Haber, and En Li
Nature. Cell, Vol. 99, 247-257, October 29, 1999
Before you read this paper
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2018/12/ 3
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Yan Zhu |
Morphogen gradient
A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
Briscoe J, Pierani A, Jessell TM, Ericson J.
Cell. 2000 May 12;101(4):435-45.
Before you read this paper
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| 2018/12/10 |
Takuji IWASATO 岩里 |
Adult neurogenesis
Neurogenesis in the adult human hippocampus
Eriksson PS, Perfilieva E, Bjork-Eriksson T, Alborn AM, Nordborg C, Peterson DA, Gage FH.
Nat Med. 1998 Nov;4(11):1313-7.
Before you read this paper
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2018/12/17
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Fumi KUBO 久保 |
Axon guidance
Floor-plate-derived netrin-1 is dispensable for commissural axon guidance.
Dominici C, Moreno-Bravo JA, Puiggros SR, Rappeneau Q, Rama N, Vieugue
P, Bernet A, Mehlen P, Chedotal A.
Nature. 2017 May 18;545(7654):350-354.
Before you read this paper
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2019/ 1/21
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Tsuyoshi KOIDE 小出 |
Development of Behavior
Main paper:
Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult.
Gross C, Zhuang X, Stark K, Ramboz S, Oosting R, Kirby L, Santarelli L, Beck S, Hen R.
Nature, 416 (6879) 396-400, 2002.
Secondary paper:
Serotonin receptor 1A knockout: An animal model of anxiety-related disorder.
Ramboz S, Oosting R, A?t Amara D, Kung HF, Blier P, Mendelsohn M, Mann JJ, Brunner D, and Hen R.
PNAS, 95 (24) 14476-14481, 1998;
Before you read this paper
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2019/ 1/28
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Yumiko SAGA 相賀 |
Adult stem cells
Main paper:
Identification of stem cells in small
intestine and colon by marker gene Lgr5
Nick Barker, Johan H. van Es, Jeroen Kuipers, Pekka Kujala, Maaike van den Born, Miranda Cozijnsen, Andrea Haegebarth, Jeroen Korving, Harry Begthel, Peter J. Peters & Hans Clevers
NATURE|Vol 449| 25 October 2007 / doi:10.1038/nature06196
Secondary paper:
A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
Hua Tian, Brian Biehs, Soren Warming, Kevin G. Leong, Linda Rangell, Ophir D. Klein & Frederic J. de Sauvage
NATURE | Vol 478 |13 October 2011 / doi:10.1038/nature10408
Before you read this paper
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The reading list and the course schedule is tentative and is subject to change.
使用する論文は変更される可能性があります． |
Appropriate grade level and Eligible Departments: (x) 1, (x) 2, (x) 3, (x) 4, (x) 5:
( ) School of Life Science， (x) All Departments，( ) Other |
Pre-requisites: Familiarity with basic concepts of Molecular and Cell Biology is recommended.
This course will be conducted in English. For questions and comments in Japanese, lecturers will provide simultaneous translation service to English.
履修条件：分子細胞生物学の基礎的知識があるとより楽しめるでしょう。
その他：この授業は英語で行いますが、日本語での質問やコメントに対しては講師が同時通訳サービスを提供します。
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Grades:
To obtain credit one must attend five or more classes (of total of eight classes) . Grades (A, B, C, D) will be determined based on the extent of participation in class.
単位取得には８セッションのうち５つ以上に出席する必要があります．成績（A,B,C,D）はクラスへの参加の程度によって判定します．
Notes:
Developmental Biology II-IV is a discussion-based course involving critical reading of the primary literature. Each year, one of the three courses (Developmental Biology II, III, or IV) will be offered, with no overlap in the material used. Taking any one of the three courses will likely give you an idea what development is about. If you wish to specialize in the field of Developmental Biology, we recommend taking all three courses.
発生生物学II-IVは原著論文をネタに議論する形式で行います．毎年3つの科目のどれか（発生生物学II, IIIまたはIV）が開講され，これら３科目での使用論文の重複はありません．どの科目を履修しても発生生物学の「味見」はできるでしょう．自分で発生研究を志しているなら３科目全てを聞いてみることをお勧めします．
Reading lists for the previous years:
2017
2016
2015
2014
2013
2012
2011
2010
2009
2008
2007
2006
Other courses in developmental biology
Developmental Biology I (e-learning course, in Japanese)
Developmental Biology (offered in the Department of Basic Biology)
Reproductive Biology (offered in the Department of Basic Biology)
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