Japanese

MURAYAMA, Yasuto

MURAYAMA, Yasuto

Department Center for Frontier Research Chromosome Biochemistry Laboratory
Job Associate Professor
Degree Doctor of Science (Yokohama City University)
Education Nihon University College of Bioresource Sciences Department of Applied Biological Science
Yokohama City University
Contact ystmurayama@nig.ac.jp

RESEARCH SUMMARY

Controlling chromosome structure is essential not only for faithful chromosome segregation but also for gene transcription and DNA replication and repair. Ring-shaped SMC complexes (cohesin, condensin and SMC5/6) are central architects of the chromosome structure. These large complexes topologically entrap DNA strands to allow vital chromosomal functions to be carried out. We have successfully purified the SMC1/3 complex and reconstituted its functional DNA binding reaction. Our aim is to investigate the molecular mechanisms by which SMC complexes regulate the chromosome structure.

LECTURE