Our laboratory is interested in relation of cellular fine structures and their functions in tissue organization. We are studying the molecular networks on cellular fine structures involved in various cell activities by molecular genetics and various imaging techniques, using a model animal, Drosophila melanogaster. Currently we are addressing the following issues; 1. Development and function of neural networks, 2. homeostasis of tissue organization and its impairment causing tumor generation.
(A) Genetically labeled neurons in a Drosophila brain. (B) Cell competition-dependent apoptosis (arrows) in mhj-/- clones (blue nuclei) and compensatory cellular hypertrophy (arrowheads) in wild-type clones (pale blue nuclei), induced in post-mitotic follicular epithelium. (C) Imaginal disc epithelium, a model for studies on tumorigenesis.
Tamori, Y., Suzuki, E., and Deng, W.M. (2016). Epithelial tumors originate in tumor hotspots, a tissue-intrinsic microenvironment. PLoS Biol 14, e1002537.
Tamori, Y., and Deng, W.M. (2014). Compensatory cellular hypertrophy: the other strategy for tissue homeostasis. Trends Cell Biol 24, 230-237.
Kurusu, M., Katsuki, T., Zinn, K., and Suzuki, E. (2012). Developmental changes in expression, subcellular distribution, and function of Drosophila N-cadherin, guided by a cellintrinsic program during neuronal differentiation. Dev Biol 366, 204-217.