文部科学省科学研究費補助金「新学術領域研究」 シリア・中心体系による生体情報フローの制御

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公募班(平成27-28年度)

A01: 水野 健作(東北大学大学院生命科学研究科)

  1. Katsuno, H., Toriyama, M., Hosokawa, Y., Mizuno, K., Ikeda, K., Sakumura, Y., and Inagaki, N. Actin migration driven by directional assembly and disassembly of membrane-anchored actin filaments. Cell Reports in press (2015).
  2. Amagai, Y., Itoh, T., Fukuda, M., and Mizuno, K. Rabin8 suppresses autophagosome formation independently of its guanine nucleotide-exchange activity toward Rab8. J. Biochem. in press (2015).
  3. Abiko, H., Fujiwara, S., Ohashi, K., Hiatari, R., Mashiko, T., Sakamoto, N., Sato, M., and Mizuno, K. Rho guanine nucleotide exchange factors involved in cyclic-stretch-induced reorientation of vascular endothelial cells. J. Cell Sci. 128, 1683-1695 (2015).
  4. Oda, T., Chiba, S., Nagai, T., and Mizuno, K. Binding to Cep164, but not EB1, is essential for centriolar localization of TTBK2 and its function in ciliogenesis. Genes Cells 19, 927-940 (2014).
  5. Homma, Y., Kanno, S. I., Sasaki, K., Nishita, M., Yasui, A., Asano, T., Ohashi, K., and Mizuno, K. Insulin receptor substrate-4 binds to Slingshot-1 phosphatase and promotes cofilin dephosphorylation. J. Biol. Chem. 289, 26302-26313 (2014).
  6. Ohashi, K., Sampei, K., Nakagawa, M., Uchiumi, N., Amanuma, T., Aiba, S., Oikawa, M., and Mizuno, K. Damnacanthal, an effective inhibitor of LIM-kinase, inhibits cell migration and invasion. Mol. Biol. Cell 25, 828-840 (2014).
  7. Nagai, T., and Mizuno, K. Multifaceted roles of Furry proteins in invertebrates and vertebrates. J. Biochem. 155, 137-146 (2014).
  8. Nagai, T., Ikeda, M., Chiba, S., Kanno, S., and Mizuno, K. (2013). Furry promotes acetylation of microtubules in the mitotic spindle via inhibition of SIRT2 tubulin-deacetylase. J. Cell Sci. 126, 4369-4380.
  9. Chiba, S., Amagai, Y., Homma, Y., Fukuda, M., and Mizuno, K. (2013). NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15. EMBO J. 32, 874-885.
  10. Higashida, C., Kiuchi, T., Akiba, Y., Mizuno, H., Maruoka, M., Narumiya, S., Mizuno, K., and Watanabe, N. (2013). F- and G-actin homeostasis regulates mechanosensitive actin nucleation by formins. Nat. Cell Biol. 15, 395-405.
  11. Borroni, E. M., Cancellieri, C., Vacchini, A., Benureau, Y., Lagane, B., Bachelerie, F., Arenzana-Seisdedos, F., Mizuno, K., Mantovani, A., Bonecchi, R., and Locati, M. (2013). b-Arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6. Sci. Signal. 6, ra30.
  12. Mizuno, K. (2013). Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation. Cell. Signal. 25, 457-469.
  13. Hou, X., Katahira, T., Ohashi, K., Mizuno, K., Sugiyama, S, and Nakamura, H. (2013). Coactosin accelerates cell dynamism by promoting actin polymerization. Dev. Biol. 379, 53-63.
  14. Ikeda, M., Chiba, S., Ohashi, K., and Mizuno, K. (2012). Furry protein promotes Aurora A-mediated Polo-like kinase 1 activation. J. Biol. Chem. 287, 27670-27681.
  15. Ohashi, K., Kiuchi, T., Shoji, K., Sampei, K., and Mizuno, K. (2012). Visualization of cofilin-actin and Ras-Raf interactions by bimolecular fluorescence complementation assays using a new pair of split Venus fragments. BioTechniques 52, 45-50.
  16. Nishio, M., Hamada, K., Kawahara, K., Sasaki, M., Noguchi, F., Chiba, S., Mizuno, K., Suzuki, S. O., Dong, Y., Tokuda, M., Morikawa, T., Hikasa, H., Eggenschwiler, J., Yabuta, N., Nojima, H., Nakagawa, K., Hata, Y., Nishina, H., Mimori, K., Mori, M., Sasaki, T., Mak, T. W., Nakano, T., Itami, S., and Suzuki, A. (2012). Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J. Clin. Invest. 122, 4505-4518.
  17. Kiuchi, T., Nagai, T., Ohashi, K., and Mizuno, K. (2011). Measurements of spatiotemporal changes in G-actin concentration reveal its effect on stimulus-induced actin assembly and lamellipodium extension. J. Cell Biol. 193, 365-380.
  18. Ohashi, K., Fujiwara, S., Watanabe, T., Kondo, H., Kiuchi, T., Sato, M., and Mizuno, K. (2011). LIM-kinase has a dual role in regulating lamellipodium extension by decelerating the rate of actin retrograde flow and the rate of actin polymerization. J. Biol. Chem. 286, 36340-36351.
  19. Itoh, G., Kanno, S., Uchida, K. S. K., Chiba, S., Sugino, S., Watanabe, K., Mizuno, K., Yasui, A., Hirota, T., and Tanaka, K. (2011). CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment. EMBO J. 30, 130-144.
  20. Tsuji, T., Ohta, Y., Kanno, Y., Hirose, K., Ohashi, K., and Mizuno, K. (2010). Involvement of p114-RhoGEF and Lfc in Wnt-3a- and Dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells. Mol. Biol. Cell 21, 3590-3600.
  21. Xiao, K., Sun, J., Kim, J., Rajagopal, S., Zhai, B., Villen, J., Haas, W., Kovacs, J. J., Shukla, A. K., Hara, M., Hernandez, M., Lachmann, A., Zhao, S., Lin, Y., Cheng, Y., Mizuno, K., Ma'ayan, A., Gygi, S. P., and Lefkowitz, R. J. (2010). Global phosphorylation analysis of b-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc. Natl. Acad. Sci. U.S.A. 107, 15299-15304.

A01: 福田 光則(東北大学大学院生命科学研究科)

  1. Tamura, K., Ohbayashi, N., Ishibashi, K. and Fukuda, M. (2011) Structure-function analysis of VPS9-ankyrin-repeat protein (Varp) in the trafficking of tyrosinase-related protein 1 in melanocytes. J. Biol. Chem. 286, 7507-7521
  2. Itoh, T., Kanno, E., Uemura, T., Waguri, S. and Fukuda, M. (2011) OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation. J. Cell Biol. 192, 839-853
  3. Matsui, T., Itoh, T. and Fukuda, M. (2011) Small GTPase Rab12 regulates constitutive degradation of transferrin receptor. Traffic 12, 1432-1443
  4. Fukuda, M., Kobayashi, H., Ishibashi, K. and Ohbayashi, N. (2011) Genome-wide investigation of the Rab binding activity of RUN domains: Development of a novel tool that specifically traps GTP-Rab35. Cell Struct. Funct. 36, 155-170
  5. Imai, A., Yoshie, S., Ishibashi, K., Haga-Tsujimura, M., Nashida, T., Shimomura, H. and Fukuda, M. (2011) EPI64 protein functions as a physiological GTPase-activating protein for Rab27 protein and regulates amylase release in rat parotid acinar cells. J. Biol. Chem. 286, 33854-33862
  6. Ishibashi, K., Fujita, N., Kanno, E., Omori, H., Yoshimori, T., Itoh, T. and Fukuda, M. (2011) Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12–5-16L2 complex. Autophagy 7, 1500-1513
  7. Ohbayashi, N., Maruta, Y., Ishida, M. and Fukuda, M. (2012) Melanoregulin regulates retrograde melanosome transport through interaction with the RILP–p150Glued complex in melanocytes. J. Cell Sci. 125, 1508-1518
  8. Ohbayashi, N., Yatsu, A., Tamura, K. and Fukuda, M. (2012) The Rab21-GEF activity of Varp, but not its Rab32/38 effector function, is required for dendrite formation in melanocytes. Mol. Biol. Cell 23, 669-678
  9. Chesneau, L., Dambournet, D., Machicoane, M., Kouranti, I., Fukuda, M., Goud, G. and Echard, A. (2012) An ARF6/Rab35 GTPase cascade for endocytic recycling and successful cytokinesis. Curr. Biol. 22, 147-153
  10. Kobayashi, H. and Fukuda, M. (2012) Rab35 regulates Arf6 activity through centaurin-β2 (ACAP2) during neurite outgrowth. J. Cell Sci. 125, 2235-2243
  11. Mori, Y., Matsui, T., Furutani, Y., Yoshihara, Y. and Fukuda, M. (2012) Small GTPase Rab17 regulates dendritic morphogenesis and postsynaptic development of hippocampal neurons. J. Biol. Chem. 287, 8963-8973
  12. Ishida, M., Ohbayashi, N., Maruta, Y., Ebata, Y. and Fukuda, M. (2012) Functional involvement of Rab1A in microtubule-dependent anterograde melanosome transport in melanocytes. J. Cell Sci. 125, 5177-5187
  13. Ishibashi, K., Uemura, T., Waguri, S. and Fukuda, M. (2012) Atg16L1, an essential factor for canonical autophagy, participates in hormone secretion from PC12 cells independently of autophagic activity. Mol. Biol. Cell 23, 3193-3202
  14. Yasuda, T., Saegusa, C., Kamakura, S., Sumimoto, H. and Fukuda, M. (2012) Rab27 effector Slp2-a transports the apical signaling molecule podocalyxin to the apical surface of MDCK II cells and regulates claudin-2 expression. Mol. Biol. Cell 23, 3229-3239
  15. Matsui, T., Ohbayashi, N. and Fukuda, M. (2012) The Rab interacting lysosomal protein (RILP) homology domain functions as a novel effector domain for small GTPase Rab36: Rab36 regulates retrograde melanosome transport in melanocytes. J. Biol. Chem. 287, 28619-28631
  16. Gálvez-Santisteban, M., Rodriguez-Fraticelli, A. E., Bryant, D. M., Vergarajauregui, S., Yasuda, T., Bañón-Rodríguez, I., Bernascone, I., Datta, A., Spivak, N., Young, K., Slim, C. L., Brakeman, P. R., Fukuda, M., Mostov, K. E. and Martín-Belmonte, F. (2012) Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells. Nature Cell Biol. 14, 838-849
  17. Yoshida-Amano, Y., Hachiya, A., Ohuchi, A., Kobinger, G. P., Kitahara, T., Takema, Y. and Fukuda, M. (2012) Essential role of RAB27A in determining constitutive human skin color. PLoS One 7, e41160
  18. Mori, Y., Matsui, T. and Fukuda, M. (2013) Rabex-5 protein regulates dendritic localization of small GTPase Rab17 and neurite morphogenesis in hippocampal neurons. J. Biol. Chem. 288, 9835-9847
  19. Matsui, T. and Fukuda, M. (2013) Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4. EMBO Rep. 14, 450-457
  20. Chiba, S., Amagai, Y., Homma, Y., Fukuda, M. and Mizuno, K. (2013) NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15. EMBO J. 32, 874-885
  21. Yatsu, A., Ohbayashi, N., Tamura, K. and Fukuda, M. (2013) Syntaxin-3 is required for melanosomal localization of Tyrp1 in melanocytes. J. Invest. Dermatol. 133, 2237-2246
  22. Kobayashi, H. and Fukuda, M. (2013) Rab35 establishes the EHD1-association site by coordinating two distinct effectors during neurite outgrowth. J. Cell Sci. 126, 2424-2435
  23. Fujita, N., Morita, E., Itoh, T., Tanaka, A., Nakaoka, M., Osada, Y., Umemoto, T., Saitoh, T., Nakatogawa, H., Kobayashi, S., Haraguchi, T., Guan, J. L., Iwai, K., Tokunaga, F., Saito, K., Ishibashi, K., Akira, S., Fukuda, M., Noda, T. and Yoshimori, T. (2013) Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin. J. Cell Biol. 203, 115-128
  24. Yasuda, T. and Fukuda, M. (2014) Slp2-a controls renal epithelial cell size through regulation of Rap–ezrin signaling independently of Rab27. J. Cell Sci. 127, 557-570
  25. Ishida, M., Arai, S. P., Ohbayashi, N. and Fukuda, M. (2014) The GTPase-deficient Rab27A(Q78L) mutant inhibits melanosome transport in melanocytes through trapping of Rab27A effector protein Slac2-a/melanophilin in their cytosol: Development of a novel melanosome-targeting tag. J. Biol. Chem. 289, 11059-11067
  26. Matsui, T., Noguchi, K. and Fukuda, M. (2014) Dennd3 functions as a guanine nucleotide exchange factor for small GTPase Rab12 in mouse embryonic fibroblasts. J. Biol. Chem. 289, 13986-13995
  27. Mori, Y., Fukuda, M. and Henley, J. M. (2014) Small GTPase Rab17 regulates the surface expression of kainate receptors but not α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in hippocampal neurons via dendritic trafficking of Syntaxin-4 protein. J. Biol. Chem. 289, 20773-20787
  28. Kobayashi, H., Etoh, K., Ohbayashi, N. and Fukuda, M. (2014) Rab35 promotes the recruitment of Rab8, Rab13 and Rab36 to recycling endosomes through MICAL-L1 during neurite outgrowth. Biol. Open 3, 803-814
  29. Nishikimi, A., Ishihara, S., Ozawa, M., Etoh, K., Fukuda, M., Kinashi, T. and Katagiri, K. (2014) Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking. Sci. Signal. 7, ra72
  30. Yatsu, A., Shimada, H., Ohbayashi, N. and Fukuda, M. (2015) Rab40C is a novel Varp-binding protein that promotes proteasomal degradation of Varp in melanocytes. Biol. Open 4, 267-275
  31. Ishida, M., Ohbayashi, N. and Fukuda, M. (2015) Rab1A regulates anterograde melanosome transport by recruiting kinesin-1 to melanosomes through interaction with SKIP. Sci. Rep. 5, 8238
  32. Etoh, K. and Fukuda, M. (2015) Structure-function analyses of the small GTPase Rab35 and its efffector protein centaurin-β2/ACAP2 during neurite outgrowth of PC12 cells. J. Biol. Chem. 290, 9064-9074

A01: 小田 賢幸(東京大学大学院医学系研究科)

  1. Oda T, Yanagisawa H, Kikkawa M.
    Detailed structural and biochemical characterization of the nexin-dynein regulatory complex.
    Molecular Biology of the Cell, 26, 264-304. 2015
  2. Oda T, Yanagisawa H, Kamiya R, Kikkawa M.
    A molecular ruler determines the repeat length in eukaryotic cilia and flagella.
    Science, 346, 857-860. 2014
  3. Oda T, Yanagisawa H, Yagi T, Kikkawa M.
    Mechanosignaling between central apparatus and radial spokes controls axonemal dynein activity.
    Journal of Cell Biology 204, 807-819. 2014.
  4. Oda T, Kikkawa M.
    Novel structural labeling method using cryo-electron tomography and biotin-streptavidin system.
    Journal of Structural Biology 183, 305-311. 2013.
  5. Oda T, Yagi T, Yanagisawa H, Kikkawa M.
    Identification of the Outer-Inner Dynein Linker as a Hub Controller for Axonemal Dynein Activities.
    Current Biology 23, 656-664. 2013.

A01: 豊島 陽子(東京大学大学院総合文化研究科)

  1. Yamaguchi, S., Saito, K., Sutoh, M., Nishizaka, T., Toyoshima, Y. Y. and *Yajima, J. Torque generation by axonemal outer-arm dynein. Biophys J, 108: 872-879 (2015) 10.1016/j.bpj.2014.12.038.
  2. Torisawa, T., Ichikawa, M., Furuta, A., Saito, K., Oiwa, K., Kojima, H., *Toyoshima, Y. Y. and *Furuta, K. Autoinhibition and cooperative activation mechanisms of cytoplasmic dynein. Nature Cell Biol. 16(11): 1118-1124 (2014) doi:0.1038/ncb3048
  3. Nishikawa, Y., Oyama, T., Kamiya, N., Kon, T., Toyoshima, Y. Y., Nakamura, H. and *Kuris, G. Structure of the entire stalk region of the dynein motor domein. J Mol Biol, 426: 3232-3245 (2014) doi: 10.1016/j.jmb.2014.06.023.
  4. Obinata, T., Amemiya, S., Takai, R., Sato, N., Ichikawa, M. & Toyoshima, Y.Y. (2014)
    Sea lily muscle lacks a troponin-regulatory system, while it contains paramyosin. Zool. Sci. 31,122-128.
  5. Ito, M., Arif Md. Rashedul Kabir, A.,M.,R. Inoue, D., Torisawa, T, Toyoshima, Y.Y., Sada1, K. & Kakugo, A.(2014)
    Formation of ring-shaped microtubule assemblies through active self-organization on dynein. Polymer J. 46, 220–225.
  6. Furuta, K., Furuta, A., Toyoshima, Y.Y., Amino, M., Oiwa, K., and Kojima, H. (2013)
    Measuring collective transport by defined numbers of processive and nonprocessive kinesin motors. Proc Natl Acad Sci U S A. 110, 501-6.
  7. Shibata, K., Miura, M., Watanabe, Y., Saito, K., Nishimura, A., Furuta, K. and Toyoshima, Y. Y. (2012)
    A Single Protofilament Is Sufficient to Support Unidirectional Walking of Dynein and Kinesin. PLoS One. 7, e42990.
  8. Toyoshima, Y. Y. and Higuchi, H. (2012)
    Motile and enzymatic properties of native dynein molecules. Handbook of Dynein pp123-144. (eds. Hirose, K. and Amos, L., Pan Stanford Publishing)
  9. Shapasand, K., Uemura, I., Saito, T., Asano, T., Hata, K., Shibata, K., Toyoshima, Y. Y., Hasegawa, M. & Hisanaga, S. (2012)
    Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylation in Alzheimer’s disease. J. Neurosci., 32, 2430-2441.
  10. Kitai, T., Watanabe, Y., Toyoshima, Y. Y., Kobayashi, T., Murayama, T., Sakaue, H., Suzuki, H., and Takahagi, T. (2011)
    Simple method of synthesizing nickel–nitrilotriacetic acid gold nanoparticles with a narrow size distribution for protein labeling. Jap. J. Appl.Phys. 50, 0950021-095024.
  11. Ichikawa, M., Watanabe, Y., Murayama, T., and Toyoshima, Y. Y. (2011)
    Recombinant human cytoplasmic dynein heavy chain 1 and 2: Observation of dynein-2 motor activity in vitro. FEBS Lett. 585, 2419–2423.
  12. Torisawa, T., Nakayama, A., Furuta, K., Yamada, M., Hirotsune, S. and Toyoshima, Y. Y. (2011)
    Functional Dissection of LIS1 and NDEL1 Towards Understanding the Molecular Mechanisms of Cytoplasmic Dynein Regulation. J. Biol.Chem. 286, 1959-1965.
  13. Miura, M., Matsubara, A., Kobayashi, T., Edamatsu, M., and Toyoshima, Y. Y. (2010)
    Nucleotide-dependent behavior of single molecules of cytoplasmic dynein on microtubules in vitro. FEBS Lett. 584, 2351-2355.

A01: 若林 憲一(東京工業大学資源化学研究所)

  1. Wakabayashi, K., Kamiya, R. (2015)
    Axonemal motility in Chlamydomonas
    Methods in Cell Biology 127:387-402
  2. Owa, M., Furuta, A., Usukura, J., Arisaka F., King, S.M., Witman, G.B., Kamiya, R., and Wakabayashi, K. (2014)
    Cooperative binding of the outer arm docking complex underlies the regular arrangement of outer arm dynein in the axoneme
    Proceedings of the National Academy of Sciences of the United States of America 111:9461-6.
  3. 荒井 祐介, 若林 憲一, 吉川 雅英, 奥 寛雅, 石川 正俊
    暗視野顕微鏡法におけるクラミドモナスの三次元トラッキング
    日本ロボット学会誌Vol. 31 (2013) No. 10 p. 1028-1035
  4. Ide, T., Owa, M., King, S.M., Kamiya, R., Wakabayashi, K. (2013)
    Protein-Protein Interactions between Intermediate Chains and the Docking Complex of Chlamydomonas Flagellar Outer Arm Dynein
    FEBS Lett. 587:2143-9.
  5. Engel, B.D., Ishikawa, H., Wemmer, K.A., Geimer, S., Wakabayashi, K., Hirono, M., Craige, B., Pazour, G.J., Witman, G.B., Kamiya, R., and Marshall, W.F. (2012)
    The role of retrograde intraflagellar transport in flagellar assembly and function
    J Cell Biol. 199:151-167.
  6. Mochiji, S., Wakabayashi, K. (2012)
    Redox regulation of phototactic migration in the green alga Chlamydomonas reinhardtii and its possible application
    Commun Integr Biol. 5:196-8
  7. VanderWaal, K.E., Yamamoto, R., Wakabayashi, K., Fox, L., Kamiya, R., Dutcher, S.K., Bayly, P., Sale, W.S., and Porter, M.E. (2011)
    bop5 mutations reveal new roles for the IC138 phosphoprotein in the regulation of flagellar behavior
    Mol Biol Cell. 22:2862-74
  8. Wakabayashi, K., Misawa, Y., Mochiji, S., and Kamiya, R. (2011)
    Reduction-oxidation poise regulates the sign of phototaxis in Chlamydomonas reinhardtii
    Proc Natl Acad Sci U S A. 108:11280-4
  9. Kohno, T., Wakabayashi, K., Diener, D.R., Rosenbaum, J.L., and Kamiya, R. (2011)
    Subunit interactions within the Chlamydomonas flagellar spokehead
    Cytoskeleton (Hoboken) 68:237-46

A01: 中山 和久(京都大学大学院薬学研究科)

  1. Takashima, K., Saitoh, A., Funabashi, T., Hirose, S., Yagi, C., Nozaki, S., Sato, S., Shin, H.-W. & Nakayama, K. (2015) COPI-mediated retrieval of SCAP is critical for regulating lipogenesis under basal and sterol-deficient conditions. J. Cell Sci., 128, in press.
  2. Kubo, K., Kobayashi, M., Nozaki, S., Yagi, C., Hatsuzawa, K., Katoh, Y., Shin, H.-W., Takahashi, S. & Nakayama, K. (2015) SNAP23/25 and VAMP2 mediate exocytic event of transferrin receptor-containing recycling vesicles. Biol. Open, 4, in press.
  3. Naito, T., Takatsu, H., Miyano, R., Takada, N., Nakayama, K. & Shin, H.-W. (2015) Phospholipid flippase ATP10A translocates phosphatidylcholine and is involved in plasma membrane dynamics. J. Biol. Chem., 290, 15004-15017.
  4. Katoh, Y., Nozaki, S., Hartanto, D., Miyano, R. & Nakayama, K. (2015) Architectures of multisubunit complexes revealed by a visible immunoprecipitation assay using fluorescent fusion proteins. J. Cell Sci., 128, 2351-2362.
  5. Ishida, R., Yamamoto, A., Nakayama, K., Sohda, M., Misumi, Y., Yasunaga, T. & Nakamura, N. (2015) GM130 is a parallel tetramer in a flexible rod-like structure and N-terminally open (Y-shaped) and closed (I-shaped) conformations. FEBS J., 282, 2232-2244.
  6. Takatsu, H., Tanaka, G., Segawa, K., Suzuki, J., Nagata, S., Nakayama, K. & Shin, H.-W. (2014) Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane. J. Biol. Chem., 289, 33543-33556.
  7. Nakazawa, S., Sakanaka, M., Furuta, K., Natsuhara, M., Takano, H., Tsuchiya, S., Okuno, Y., Ohtsu, H., Nishibori, M., Thurmond, R.L., Hirasawa, N., Nakayama, K., Ichikawa, A., Sugimoto, Y. & Tanaka, S. (2014) Histamine synthesis is required for granule maturation in murine mast cells. Eur. J. Immunol., 44, 204-214.
  8. Nakai, W., Kondo, Y., Saitoh, A., Naito, T., Nakayama, K. & Shin, H.-W. (2013) ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus. Mol. Biol. Cell, 24, 2570-2581.
  9. Ueda, T., Hanai, A., Takei, T., Kubo, K., Ohgi, M., Sakagami, H., Takahashi, S., Shin, H.-W. & Nakayama, K. (2013) EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis. FEBS Lett., 587, 1617-1623.
  10. Takatsu, H., Katoh, Y., Ueda, T., Waguri, S., Murayama, T., Takahashi, S., Shin, H.-W. & Nakayama, K. (2013) Mitosis-coupled, microtubule-dependent clustering of endosomal vesicles around centrosomes. Cell Struct. Funct., 38, 31-41.
  11. Kondo, Y., Hanai, A., Nakai, W., Katoh, Y., Nakayama, K. & Shin, H.-W. (2012) ARF1 and ARF3 are required for the integrity of recycling endosomes and the recycling pathway. Cell Struct. Funct., 37, 141-154.
  12. Nakamura, K., Man, Z., Xie, Y., Hanai, A., Makyio, H., Kawasaki, M., Kato, R., Shin, H.-W., Nakayama, K. & Wakatsuki, S. (2012) Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase. J. Biol. Chem., 287, 25478-25489.
  13. Takahashi, S., Kubo, K., Waguri, S., Yabashi, A., Shin, H.-W., Katoh, Y. & Nakayama, K. (2012) Rab11 regulates exocytosis of recycling vesicles at the plasma membrane. J. Cell Sci., 125, 4049-4057.
  14. Makyio, H., Ohgi, M., Takei, T., Takahashi, S., Takatsu, H., Katoh, Y., Hanai, A., Ueda, T., Kanaho, Y., Xie, Y., Shin, H.-W., Kamikubo, H., Kataoka, M., Kawasaki, M., Kato, R., Wakatsuki, S. & Nakayama, K. (2012) Structural basis for Arf6–MKLP1 complex formation on the Flemming body responsible for cytokinesis. EMBO J., 31, 2590-2603.
  15. Fukumatsu, M., Ogawa, M., Arakawa, S., Suzuki, M., Furuse, M., Nakayama, K., Shimizu, S., Kim, M., Mimuro, H. & Sasakawa, C. (2012) Shigella targets epithelial tricellular junctions and uses a noncanonical clathrin-dependent endocytic pathway to spread between cells. Cell Host Microbe, 11, 325-336.
  16. Takano, H., Furuta, K., Yamashita, K., Sakanaka, M., Itano, N., Gohda, E., Nakayama, K., Kimata, K., Sugimoto, Y., Ichikawa, A. & Tanaka, S. (2012) Restriction of mast cell proliferation through hyaluronan synthesis by co-cultured fibroblasts. Biol. Pharm. Bull., 35, 408-412.
  17. Takashima, K., Saitoh, A., Hirose, S., Nakai, W., Kondo, Y., Takasu, Y., Kakeya, H., Shin, H.-W. & Nakayama, K. (2011) GBF1-Arf-COPI-ArfGAP–mediated Golgi-to-ER transport involved in regulation of lipid homeostasis. Cell Struct. Funct., 36, 223-235.
  18. Takatsu, H., Baba, K., Shima, T., Umino, H., Kato, U., Umeda, M., Nakayama, K. & Shin, H.-W. (2011) ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50-independent manner. J. Biol. Chem., 286, 38159-38167.
  19. Takahashi, S., Takei, T., Koga, H., Takatsu, H., Shin, H.-W. & Nakayama, K. (2011) Distinct roles of Rab11 and Arf6 in the regulation of Rab11-FIP3/Arfophilin-1 localization in mitotic cells. Genes Cells, 16, 938-950.
  20. Man, Z., Kondo, Y., Koga, H., Umino, H., Nakayama, K. & Shin, H.-W. (2011) Arfaptins are localized to the trans-Golgi by interaction with Arl1, but not Arfs. J. Biol. Chem., 286, 11569-11578.

A01: 藤原 敬宏(京都大学物質-細胞統合システム拠点)

  1. Hiramoto-Yamaki, N., Tanaka, K.A., Suzuki, K.G., Hirosawa, K.M., Miyahara, M.S., Kalay, Z., Tanaka, K., Kasai, R.S., Kusumi, A., and Fujiwara, T.K. (2014). Ultrafast diffusion of a fluorescent cholesterol analog in compartmentalized plasma membranes. Traffic 15, 583-612.
  2. Kalay, Z., Fujiwara, T.K., Otaka, A., and Kusumi, A. (2014). Lateral diffusion in a discrete fluid membrane with immobile particles. Phys. Rev. E 89, 022724.
  3. Imayoshi, I., Isomura, A., Harima, Y., Kawaguchi, K., Kori, H., Miyachi, H., Fujiwara, T., Ishidate, F., and Kageyama, R. (2013). Oscillatory control of factors determining multipotency and fate in mouse neural progenitors. Science 342, 1203-1208.
  4. Yoshikawa, N., Hirori, H., Watanabe, H., Aoki, T., Ihara, T., Kusuda, R., Wolpert, C., Fujiwara, T.K., Kusumi, A., Kanemitsu, Y., and Tanaka, K. (2013). Biexciton state causes photoluminescence fluctuations in CdSe/ZnS core/shell quantum dots at high photoexcitation densities. Phys. Rev. B 88, 155440.
  5. Nishimura, H., Ritchie, K., Kasai, R.S., Goto, M., Morone, N., Sugimura, H., Tanaka, K., Sase, I., Yoshimura, A., Nakano, Y., Fujiwara, T.K., and Kusumi, A. (2013). Biocompatible fluorescent silicon nanocrystals for single-molecule tracking and fluorescence imaging. J. Cell Biol. 202, 967-983.
  6. Koyama-Honda, I., Itakura, E., Fujiwara, T.K., and Mizushima, N. (2013). Temporal analysis of recruitment of mammalian ATG proteins to the autophagosome formation site. Autophagy 9, 1491-1499.
  7. Takamatsu, S., Onoguchi, K., Onomoto, K., Narita, R., Takahasi, K., Ishidate, F., Fujiwara, T.K., Yoneyama, M., Kato, H., and Fujita, T. (2013). Functional characterization of domains of IPS-1 using an inducible oligomerization system. PLoS One 8, e53578.
  8. Shibata, A.C., Chen, L.H., Nagai, R., Ishidate, F., Chadda, R., Miwa, Y., Naruse, K., Shirai, Y.M., Fujiwara, T.K., and Kusumi, A. (2013). Rac1 recruitment to the archipelago structure of the focal adhesion through the fluid membrane as revealed by single-molecule analysis. Cytoskeleton 70, 161-177.
  9. Suzuki, K.G., Kasai, R.S., Hirosawa, K.M., Nemoto, Y.L., Ishibashi, M., Miwa, Y., Fujiwara, T.K., and Kusumi, A. (2012). Transient GPI-anchored protein homodimers are units for raft organization and function. Nat. Chem. Biol. 8, 774-783.
  10. Shibata, A.C., Fujiwara, T.K., Chen, L., Suzuki, K.G., Ishikawa, Y., Nemoto, Y.L., Miwa, Y., Kalay, Z., Chadda, R., Naruse, K., and Kusumi, A. (2012). Archipelago architecture of the focal adhesion: membrane molecules freely enter and exit from the focal adhesion zone. Cytoskeleton 69, 380-392.
  11. Sheng, R., Chen, Y., Yung Gee, H., Stec, E., Melowic, H.R., Blatner, N.R., Tun, M.P., Kim, Y., Kallberg, M., Fujiwara, T.K., Hong, J.H., Kim, K.P., Lu, H., Kusumi, A., Lee, M.G., and Cho, W. (2012). Cholesterol modulates cell signaling and protein networking by specifically interacting with PDZ domain-containing scaffold proteins. Nat. Commun. 3, 1249.
  12. Kalay, Z., Fujiwara, T.K., and Kusumi, A. (2012). Confining domains lead to reaction bursts: reaction kinetics in the plasma membrane. PLoS One 7, e32948.
  13. Kasai, R.S., Suzuki, K.G., Prossnitz, E.R., Koyama-Honda, I., Nakada, C., Fujiwara, T.K., and Kusumi, A. (2011). Full characterization of GPCR monomer-dimer dynamic equilibrium by single molecule imaging. J. Cell Biol. 192, 463-480.
  14. Tanaka, K.A., Suzuki, K.G., Shirai, Y.M., Shibutani, S.T., Miyahara, M.S., Tsuboi, H., Yahara, M., Yoshimura, A., Mayor, S., Fujiwara, T.K., and Kusumi, A. (2010). Membrane molecules mobile even after chemical fixation. Nat. Methods 7, 865-866.
  15. Umemura, Y.M., Vrljic, M., Nishimura, S.Y., Fujiwara, T.K., Suzuki, K.G., and Kusumi, A. (2008). Both MHC class II and its GPI-anchored form undergo hop diffusion as observed by single-molecule tracking. Biophys. J. 95, 435-450.

A01: 藤森 俊彦(基礎生物学研究所)

  1. Shi D, Komatsu K, Hirao M, Toyooka Y, Koyama H, Tissir F, Goffinet AM, Uemura T, Fujimori T. Celsr1 is required for the generation of polarity at multiple levels of the mouse oviduct. Development. 141, 4558-68. (2014)
  2. Imuta Y, Koyama H, Shi D, Eiraku M, Fujimori T, Sasaki H. Mechanical control of notochord morphogenesis by extra-embryonic tissues in mouse embryos. Mech Dev. 132, 44-58. (2014)
  3. Abe T, Sakaue-Sawano A, Kiyonari H, Shioi G, Inoue K, Horiuchi T, Nakao K, Miyawaki A, Aizawa S, Fujimori T. Visualization of cell cycle in mouse embryos with Fucci2 reporter directed by Rosa26 promoter. Development. 140, 237-46. (2013)
  4. Bashar MK, Komatsu K, Fujimori T, Kobayashi TJ. Automatic extraction of nuclei centroids of mouse embryonic cells from fluorescence microscopy images. PLoS One. 7, e35550. (2012)
  5. Shi D, Komatsu K, Uemura T, Fujimori T. Analysis of ciliary beat frequency and ovum transport ability in the mouse oviduct. Genes Cells. 16, 282-90. (2011)
  6. Abe T, Kiyonari H, Shioi G, Inoue K, Nakao K, Aizawa S, Fujimori T. Establishment of conditional reporter mouse lines at ROSA26 locus for live cell imaging. Genesis. 49, 579-90. (2011)
  7. Tissir F, Qu Y, Montcouquiol M, Zhou L, Komatsu K, Shi D, Fujimori T, Labeau J, Tyteca D, Courtoy P, Poumay Y, Uemura T, Goffinet AM. Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nat Neurosci. 13, 700-7. (2010)

A02: 大森 俊宏(東北大学大学院工学研究科)

  1. T. Omori, T. Ishikawa, D.Barthes-Biesel, A.-V. Salsac, J. Walter, Y. Imai, and T. Yamaguchi, Comparison between spring network models and continuum constitutive laws: application to the large deformation of a capsule in shear flow, Phys Rev E 83 (2011) 041918
  2. Toshihiro Omori, Yohsuke Imai, Takami Yamaguchi, and Takuji Ishikawa, Reorientation of a nonspherical capsule in creeping shear flow, Phys Rev Lett 108 (2012) 138102 被引用数:17件
  3. T. Omori, T. Ishikawa, D. Barthes-Biesel, A.-V. Salsac, Y. Imai, and T. Yamaguchi, Tension of red blood cell membrane in simple shear flow, Phys Rev E 86 (2012) 056321
  4. Toshihiro Omori, Takuji Ishikawa, Yohsuke Imai, and Takami Yamaguchi, Membrane tension of red blood cells pairwisely interacting in simple shear flow, J Biomech 46 (2013) 548-553
  5. T. Omori, T. Ishikawa, Y. Imai, and T. Yamaguchi, Shear-induced diffusion of red blood cells in a semi-dilute suspension, J Fluid Mech 724 (2013) 154-174
  6. Toshihiro Omori, Haruki Hosaka, Yohsuke Imai, Takami Yamaguchi, and Takuji Ishikawa, Numerical analysis of a red blood cell flowing thorough a thin micropore, Phys Rev E 89 (2014) 013008
  7. Toshihiro Omori, Takuji Ishikawa, Yohsuke Imai, and Takami Yamaguchi, Hydrodynamic interaction between two red blood cells in simple shear flow: its impact on the rheology of a semi-dilute suspension, Comput Mech 54 (2014) 933-941
  8. Daiki MATSUNAGA, Yohsuke IMAI, Toshihiro OMORI, Takuji ISHIKAWA, and Takami YAMAGUCHI, A full GPU implementation of a numerical method for simulating capsule suspensions, J Biomech Sci Eng 9 (2014) 14-00039
  9. T. Omori, and T. Ishikawa, Upward swimming of a sperm cell in shear flow, submitted
  10. K. Kyoya, D. Matsunaga, Y. Imai, T. Omori, and T. Ishikawa, Shape matters: Near-field mechanics dominates collective motions of ellipsoidal squirmers, submitted
  11. Toshihiro Omori, Yohsuke Imai, Kenji Kikuchi, Takuji Ishikawa, and Takami Yamaguchi, Hemodynamics in the Microcirculation and in Microfluidics, Annals of Biomedical Engineering, 43 (2015) 238-257
  12. Yohsuke Imai, Toshihiro Omori, Yuji Shimogonya, Takami Yamaguchi, and Takuji Ishikawa, Numerical methods for simulating blood flow at micro-, macro-, and multi-scales, submitted

A02: 稲葉 一男(筑波大学下田臨海実験センター)

  1. Konno A, Shiba K, Cai C, Inaba K. (2015) Branchial cilia and sperm flagella recruit distinct axonemal components. PLoS One. 10(5):e0126005.
  2. Inaba K. (2015) Calcium sensors of ciliary outer arm dynein: functions and phylogenetic considerations for eukaryotic evolution. Cilia. 4:6.
  3. Yaguchi S, Yaguchi J, Inaba K. (2014) Bicaudal-C is required for the formation of anterior neurogenic ectoderm in the sea urchin embryo. Sci Rep, 4:6852.
  4. Shiba K, Inaba K. (2014) Distinct roles of soluble and transmembrane adenylyl cyclases in the regulation of flagellar motility in ciona sperm. Int J Mol Sci. 15:13192-13208.
  5. Hirohashi N, Alvarez L, Shiba K, Fujiwara E, Iwata Y, Mohri T, Inaba K, Chiba K, Ochi H, Supuran CT, Kotzur N, Kakiuchi Y, Kaupp UB, Baba SA. (2013) Sperm from sneaker male squids exhibit chemotactic swarming to CO2. Curr Biol. 23:775-781.
  6. Jin Y, Yaguchi S, Shiba K, Yamada L, Yaguchi J, Shibata D, Sawada H, Inaba K. (2013) Glutathione transferase theta in apical ciliary tuft regulates mechanical reception and swimming behavior of sea urchin embryos. Cytoskeleton 70:453-470.
  7. Saito T, Shiba K, Inaba K, Yamada L, and Sawada H. (2012) Self-incompatibility response induced by calcium increase in sperm of the ascidian Ciona intestinalis. Proc Natl Acad Sci USA. (2012) 109:4158-4162.
  8. Mohri H, Inaba K, Ishijima S, Baba SA. (2012) Tubulin-dynein system in flagellar and ciliary movement. Proc Jpn Acad Ser B 88:397-415.
  9. Mizuno K, Shiba K, Okai M, Takahashi Y, Shitaka Y, Oiwa K, Tanokura M, Inaba K. (2012) Calaxin drives sperm chemotaxis by Ca2+-mediated direct modulation of a dynein motor. Proc Natl Acad Sci USA.109:20497-20502.
  10. Inaba K. (2011) Sperm flagella: comparative and phylogenetic perspectives of protein components. Mol Hum Reprod. 17:524-538.
  11. Yaguchi S, Yaguchi J, Wei Z, Jin Y, Angerer LM, Inaba K. (2011) Fez function is required to maintain the size of the animal plate in the sea urchin embryo. Development. 138:4233-4243.
  12. 稲葉一男 (2014). カルシウムシグナルによる哺乳類精子超活性化の制御. 細胞工学,Vol. 33(4), 366-371.
  13. 水野克俊, 柴小菊, 稲葉一男 (2013). 精子が卵を目指すしくみ―運動の方向転換を司るタンパク質「カラクシン」. 遺伝,Vol. 67(5), 610-617.

A02: 武川 睦寛(東京大学医科学研究所)

  1. Ichikawa K, Kubota Y, Nakamura T, Weng JS, Tomida T, Saito H and Takekawa M. MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP. Molecular Cell 58: 35-46 (2015)
  2. Sato Y, Goto E, Shibata Y, Kubota Y, Yamagata A, Goto-Ito S, Kubota K, Inoue J, Takekawa M, Tokunaga F, Fukai S. Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity. Nature Struct. & Mol. Biol. 22: 222-229 (2014)
  3. Nakamura T, Saito H and Takekawa M. SAPK pathways and p53 cooperatively regulate PLK4 activity and centrosome integrity under stress. Nature Commun. 4:1775 doi: 10.1038/ncomms2752 (2013)
  4. Tomida T, Osa S, Takekawa M, Iino Y and Saito H. The temporal pattern of stimulation determines the extent and duration of MAPK activation in a caenorhabditis elegans sensory neuron. Science Signaling 5, ra76 (2012)
  5. Otsuka M, Takata A, Yoshikawa T, Kojima K, Kishikawa T, Shibata C, Takekawa M, Yoshida H, Omata M, and Koike K. Receptor for activated protein kinase C: Requirement for efficient microRNA function and reduced expression in hepatocellular carcinoma. PLoS ONE 6, e24359 (2011)
  6. Kubota Y, O’Grady P, Saito H and Takekawa M. Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation. Nature Cell Biol. 13, 282-291 (2011)

A02: 池上 浩司(浜松医科大学)

  1. Hayasaka T, Goto-Inoue N, Masaki N, Ikegami K, Setou M. Application of 2,5-dihydroxyacetophenone with sublimation provides more efficientionization of lipid species by atmospheric-pressure matrix-assisted laser desorption/ionization imaging mass spectrometry. Surf Interface Anal. 46(12-13):1219-1222, 2014.
  2. Cytosolic carboxypeptidase 5 removes α- and γ-linked glutamates from tubulin. Berezniuk I, Lyons PJ, Sironi JJ, Xiao H, Setou M, Angeletti RH, Ikegami K, Fricker LD. J Biol Chem. 288(42):30445-30453, 2013.
  3. Konno A, Setou M, Ikegami K. Ciliary and flagellar structure and function--their regulations by posttranslational modifications of axonemal tubulin. Int Rev Cell Mol Biol. 294:133-171, 2012.
  4. Lee JE, et al. CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium. Nat Genet. 44(2):193-199, 2012.
  5. Berezniuk I, Vu HT, Lyons PJ, Sironi JJ, Xiao H, Burd B, Setou M, Angeletti RH, Ikegami K, Fricker LD. Cytosolic carboxypeptidase 1 is involved in processing α- and β-tubulin. J Biol Chem. 287(9):6503-6517, 2012.
  6. Ikegami K, Sato S, Nakamura K, Ostrowski LE, Setou M. Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry. Proc Natl Acad Sci USA. 107(23):10490-10495, 2010.
  7. Ikegami K, Setou M. Unique post-translational modifications in specialized microtubule architecture. Cell Struct Funct. 35(1):15-22, 2010.
  8. Ikegami K, Setou M. TTLL10 can perform tubulin glycylation when co-expressed with TTLL8. FEBS Lett. 583(12):1957-1963, 2009.

A02: 花房 洋(名古屋大学大学院理学研究科)

  1. Hanafusa, H., Kedashiro, S., Tezuka, M., Funatsu, M., Usami, S., Toyoshima, F., and Matsumoto, K.
    PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2. Nat. Cell Biol. in press
  2. Kedashiro, S., Pastuhov, S.I., Nishioka, T., Watanabe, T., Kaibuchi, K., Matsumoto, K., and Hanafusa, H.
    LRRK1-phosphorylated CLIP-170 regulates EGFR trafficking by recruiting p150Glued to microtubule plus ends. J. Cell Sci., 128:385-396 (2015)
  3. Ishikawa, K., Nara, A., Matsumoto, K., and Hanafusa, H.
    EGFR-dependent phosphorylation of Leucine-rich repeat kinase LRRK1 is important for proper endosomal trafficking of EGFR. Mol. Biol. Cell, 23:1294-1306 (2012).
  4. Hanafusa, H., Ishikawa, K., Kedashiro, S., 以下省略(10人中1番目)
    Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor. Nat. Commun., 2:158 (2011).

A02: 西田 満(神戸大学大学院医学研究科)

  1. Endo, M., Nishita, M., Fujii, M., and Minami, Y. (2015). Insight into the role of Wnt5a-induced signaling in normal and cancer cells. Int. Rev. Cell Mol. Biol. 314: 117-148.
  2. Homma, Y., Kanno, S., Sasaki, K., Nishita, M., Yasui, A., Asano, T., Ohashi, K., and Mizuno, K. (2014). Insulin receptor substrate-4 binds to Slingshot-1 phosphatase and promotes cofilin dephosphorylation. J. Biol. Chem. 289: 26302-26313.
  3. Nishita, M., Qiao, S., Miyamoto, M., Okinaka, Y., Yamada, M., Hashimoto, R., Iijima, K., Otani, H., Hartmann, C., Nishinakamura, R., and Minami, Y. (2014). Role of Wnt5a-Ror2 signaling in morphogenesis of the metanephric mesenchyme during ureteric budding. Mol. Cell. Biol. 34:3096-3105.
  4. Mori, K., Kitazawa, R., Kondo, T., Mori, M., Hamada, Y., Nishita, M., Minami, Y., Haraguchi, R., and Kitazawa, S. (2014). Oxidative stress-induced osteopenia by decreased beta-catenin signaling is partly induced by epigenetic derepression of sFRP-4 gene. PLoS ONE 9:e102797.
  5. Doi, R., Endo, M., Yamakoshi, K., Yamanashi, Y., Nishita, M., Fukada, S. I., and Minami, Y. (2014). Critical role of Frizzled1 in age-related alterations of Wnt/beta-catenin signal in myogenic cells during differentiation. Genes Cells 19:287-296.
  6. Li, X., Yamagata, K., Nishita, M., Endo, M., Arfian, N., Rikitake, Y., Emoto, N., Hirata, K., Tanaka, Y., and Minam, Y. (2013). Activation of Wnt5a-Ror2 signaling associated with epithelial-to-mesenchymal transition (EMT) of tubular epithelial cells during renal fibrosis. Genes Cells 18: 608-619.
  7. Maeda, K., Kobayashi, Y., Udagawa, N., Uehara, S., Ishihara, A., Mizoguchi, T., Kikuchi, Y., Takada, I., Kato, S., Kani, S., Nishita, M., Marumo, K., Martin, T. J., Minami, Y., and Takahashi, N. (2013). Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis. Nat. Med. 18: 405-412.
  8. Endo, M., Doi, R., Nishita, M., and Minami, Y. (2012). Ror family receptor tyrosine kinases regulate the maintenance of neural progenitor cells in the developing neocortex. J. Cell Sci. 125: 2017-2029.
  9. Yamagata, K., Li, X., Ikegaki, S., Oneyama, C., Okada, M., Nishita, M., and Minami, Y. (2012). Dissection of Wnt5a-Ror2 Signaling Leading to Matrix Metalloproteinase (MMP-13) Expression. J. Biol. Chem. 287: 1588-1599.
  10. Ren, D., Minami, Y., and Nishita, M. (2011). Critical role of Wnt5a–Ror2 signaling in motility and invasiveness of carcinoma cells following Snail-mediated epithelial-mesenchymal transition. Genes Cells 16: 304-315.
  11. Nishita, M., Itsukushima, S., Nomachi, A., Endo, M., Wang, Z., Inaba, D., Qiao, S., Takada, S., Kikuchi, A., and Minami, Y. (2010). Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization. Mol. Cell. Biol. 30: 3610-3619.
  12. Nishita, M., Enomoto, M., Yamagata, K., and Minami, Y. (2010). Cell/tissue-tropic functions of Wnt5a signaling in normal and cancer cells. Trends Cell Biol. 20: 346-354.
  13. Yamada, M., Udagawa, J., Matsumoto, A., Hashimoto, R., Hatta, T., Nishita, M., Minami, Y., and Otani, H. (2010). Ror2 is required for midgut elongation during mouse development. Dev. Dyn. 239: 941-953.

A02: 小林 哲夫(奈良先端科学技術大学院大学バイオサイエンス研究科)

  1. Kobayashi T*#, Kim S*, Lin YC, Inoue T, Dynlacht BD#. (*These authors contributed equally to this work.) (#Corresponding author)
    The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly
    J. Cell Biol., 204: 215-229 (2014)
  2. Li J, D’Angiolella V, Seeley ES, Kim S, Kobayashi T, Fu W, Campos EI, Pagano M, Dynlacht BD.
    USP33 regulates centrosome biogenesis via deubiquitylation of the centriolar protein CP110.
    Nature 495: 255-259 (2013)
  3. Li J, Kim S*, Kobayashi T*, Liang FX, Korzeniewski N, Duensing S, Dynlacht BD. (*These authors contributed equally to this work.)
    Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres.
    EMBO Rep. 13: 547-553 (2012)
  4. Kobayashi T*, Tsang WY*, Li J, Lane W, Dynlacht BD. (*These authors contributed equally to this work.)
    Centriolar Kinesin Kif24 Interacts with CP110 to Remodel Microtubules and Regulate Ciliogenesis.
    Cell 145: 914-925 (2011)
  5. Kobayashi T, Dynlacht BD.
    Regulating the transition from centriole to basal body.
    J. Cell Biol. 193: 435-444 (2011).
  6. Nakae I*, Fujino T*, Kobayashi T*, Sasaki A, Kikko Y, Fukuyama M, Gengyo-Ando K, Mitani S, Kontani K, Katada T. (*These authors contributed equally to this work.)
    The Arf-like GTPase Arl8 mediates delivery of endocytosed macromolecules to lysosomes in C. elegans.
    Mol. Biol. Cell 21: 2434-2442 (2010).

A02: 宮本 達雄(広島大学原爆放射線医科学研究所)

  1. YAP is essential for tissue tension to ensure vertebrate 3D body shape. Porazinski S*, Wang H*, Asaoka Y*, Behrndt M*, Miyamoto T*, Morita H, Hata S, Sasaki T, Krens SF, Osada Y, Asaka S, Momoi A, Linton S, Miesfeld JB, Link BA, Senga T, Castillo-Morales A, Urrutia AO, Shimizu N, Nagase H, Matsuura S, Bagby S, Kondoh H, Nishina H, Heisenberg CP, Furutani-Seiki M. (* Equal contribution) Nature, 521(7551):217-221, (2015)
  2. The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation. Miyamoto T, Hosoba K, Ochiai H, Royba E, Izumi H, Sakuma T, Yamamoto T, Dynlacht BD, Matsuura S. Cell Rep, pii: S2211-1247(15)00004-2, (2015)
  3. TALEN-mediated single-base-pair editing identification of an intergenic mutation of upstream of BUB1B as causative of PCS (MVA) syndrome. Ochiai H*, Miyamoto T*, Kanai A, Hosoba K, Sakuma T, Kudo Y, Asami K, Ogawa A, Watanabe A, Kajii K, Ymamoto T, Matsuura S. (* Equal contribution) Proc Natl Acad Sci USA, 111:1461-1466, (2014)
  4. Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity. Sakuma T, Ochiai H, Kaneko T, Mashimo T, Tokumasu D, Sakane Y, Suzuki K, Miyamoto T, Sakamoto N, Matsuura S, Yamamoto T. Sci Rep, 3: 3379, (2013)
  5. Efficient TALEN construction and evaluation methods for human cell and animal applications. Sakuma T, Hosoi S, Woltjen K, Suzuki KI, Kashiwagi K, Wada H, Ochiai H, Miyamoto T, Kawai N, Sasakura Y, Matsuura S, Okada Y, Kawahara A, Hayashi S, Yamamoto T. Genes Cells, 18: 315-326, (2013)
  6. Zinc-finger nuclease-mediated targeted insertion of reporter genes for quantitative imaging of gene expression in sea urchin embryos. Ochiai H, Sakamoto N, Nishikawa M, Suzuki K, Matsuura S, Miyamoto T, Sakuma T, Shibata T, Yamamoto T. Proc Natl Acad Sci USA, 109:10915−10920,(2012)
  7. Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates. Miyamoto T, Porazinski S, Wang H, Borovina A, Ciruna B, Shimizu A, Kajii T, Kikuchi A, Furutani-Seiki M, Matsuura S. Hum Mol Genet, 20(10):2058-2070, (2011)
  8. Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly. Matsumoto Y, Miyamoto T, Sakamoto H, Izumi H, Nakazawa Y, Ogi T, Tahara H, Oku S, Hiramoto A, Shiiki T, Fujisawa Y, Ohashi H, Matsuura S. DNA Repair (Amst), 10(3):314-321 (2011)
  9. In Vivo Imaging of Tight Junctions Using Claudin-EGFP transgenic Medaka. Miyamoto T, Furuse M, Furutani-Seiki M. Methods Mol Biol, 10(3):314-321 (2011)
  10. HpSulf, a heparan sulfate 6-O-endosulfatase, is involved in the regulation of VEGF signaling during sea urchin development. Fujita K, Takechi E, Sakamoto N, Sumiyoshi N, Izumi S, Miyamoto T, Matsuura S, Tsurugaya T, Akasaka K, Yamamoto T. Mech Dev, 127(3-4):235-45 (2010)

A02: 西坂 崇之(学習院大学物理学科)

  1. Kurushima, J., D. Nakane, T. Nishizaka, and H. Tomita. 2015. Bacteriocin protein BacL1 of Enterococcus faecalis targets cell division loci and specifically recognizes L-Ala2-cross-bridged peptidoglycan. Journal of bacteriology 197:286-295.
  2. Kinosita, Y., D. Nakane, M. Sugawa, T. Masaike, K. Mizutani, M. Miyata, and T. Nishizaka. 2014. Unitary step of gliding machinery in Mycoplasma mobile. Proc Natl Acad Sci USA 111:8601-8606.
  3. Yogo, K., T. Ogawa, M. Hayashi, Y. Harada, T. Nishizaka, and K. Kinosita, Jr. 2012. Direct observation of strand passage by DNA-topoisomerase and its limited processivity. PloS one 7:e34920.
  4. Sato, C., S. Manaka, D. Nakane, H. Nishiyama, M. Suga, T. Nishizaka, M. Miyata, and Y. Maruyama. 2012. Rapid imaging of mycoplasma in solution using Atmospheric Scanning Electron Microscopy (ASEM). Biochem Biophys Res Commun 417:1213-1218.
  5. Kim, K., J. Yajima, Y. Oh, W. Lee, S. Oowada, T. Nishizaka, and D. Kim. 2012. Nanoscale localization sampling based on nanoantenna arrays for super-resolution imaging of fluorescent monomers on sliding microtubules. Small 8:892-900, 786.
  6. Adachi, K., K. Oiwa, M. Yoshida, T. Nishizaka, and K. Kinosita, Jr. 2012. Controlled rotation of the F1-ATPase reveals differential and continuous binding changes for ATP synthesis. Nature communications 3:1022.
  7. Tsuji, T., S. Kawai-Noma, C. G. Pack, H. Terajima, J. Yajima, T. Nishizaka, M. Kinjo, and H. Taguchi. 2011. Single-particle tracking of quantum dot-conjugated prion proteins inside yeast cells. Biochem Biophys Res Commun 405:638-643.
  8. Sugawa, M., K. A. Okada, T. Masaike, and T. Nishizaka. 2011. A change in the radius of rotation of F1-ATPase indicates a tilting motion of the central shaft. Biophys J 101:2201-2206.
  9. Nishizaka, T., Y. Hasimoto, and T. Masaike. 2011. Simultaneous observation of chemomechanical coupling of a molecular motor. Methods Mol Biol 778:259-271.
  10. Nishizaka, T. 2010. Molecular bio-motors in living cells. Adv Biochem Eng Biotechnol 119:3-15.
  11. Yajima, J., K. Mizutani, and T. Nishizaka. 2008. A torque component present in mitotic kinesin Eg5 revealed by three-dimensional tracking. Nature structural & molecular biology 15:1119-1121.
  12. Masaike, T., F. Koyama-Horibe, K. Oiwa, M. Yoshida, and T. Nishizaka. 2008. Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80 degrees and 40 degrees substep rotations. Nature structural & molecular biology 15:1326-1333.
  13. Nishizaka, T., K. Oiwa, H. Noji, S. Kimura, E. Muneyuki, M. Yoshida, and K. Kinosita, Jr. 2004. Chemomechanical coupling in F1-ATPase revealed by simultaneous observation of nucleotide kinetics and rotation. Nature structural & molecular biology 11:142-148.
  14. Nishizaka, T., Q. Shi, and M. P. Sheetz. 2000. Position-dependent linkages of fibronectin- integrin-cytoskeleton. Proc Natl Acad Sci U S A 97:692-697.
  15. Nishizaka, T., H. Miyata, H. Yoshikawa, S. Ishiwata, and K. Kinosita, Jr. 1995. Unbinding force of a single motor molecule of muscle measured using optical tweezers. Nature 377:251-254.
  16. Nishizaka, T., T. Yagi, Y. Tanaka, and S. Ishiwata. 1993. Right-handed rotation of an actin filament in an in vitro motile system. Nature 361:269-271.

A02: 福井 一(国立循環器病研究センター研究所)

  1. Fukuhara S, Fukui H, Wakayama Y, Ando K, Nakajima H, and Mochizuki N. (2015). Looking back and moving forward: Recent advances in understanding of cardiovascular development by imaging of zebrafish. Dev Growth Differ., 57, 333-40.
  2. Kashiwada T, Fukuhara S, Terai K, Tanaka T, Wakayama Y, Ando K, Nakajima H, Fukui H, Yuge S, Saito Y, Gemma A, and Mochizuki N. (2015).
    b-catenin-dependent transcription is central to Bmp-mediated formation of venous vessels.
    Development, 142, 497-509.
  3. Fukui H, Terai K, Nakajima H, Chiba A, Fukuhara S, and Mochizuki N. (2014).
    S1P-Yap1 signaling regulates endoderm formation required for cardiac precursor cell migration in zebrafish.
    Dev Cell, 31, 128-36.
  4. Fukui H, Shiba D, Asakawa K, Kawakami K, and Yokoyama T. (2012).
    The ciliary protein Nek8/Nphp9 acts downstream of Inv/Nphp2 during pronephros morphogenesis and left-right establishment in zebrafish.
    FEBS Lett., 586, 2273-2279.
  5. Mitsui S, Torii K, Fukui H, Tsujimura K, MaedaA, Nose M, Nagatsu A, Mizukami H, and Morita A. (2010).
    The herbal medicine compound falcarindiol from Notopterygii Rhizoma suppresses dendritic cell maturation.
    J. Pharmacol. Exp. Ther., 333, 954-960.
  6. Fukui H, Hanaoka R, and Kawahara A. (2009).
    Noncanonical activity of seryl-tRNA synthetase is involved in vascular development.
    Circ. Res., 104, 1253-1259.
  7. Kawahara A, Nishi T, Hisano Y, Fukui H, Yamaguchi A, and Mochizuki N. (2009).
    The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors.
    Science, 323, 524-527.

A03: 貝淵 弘三(名古屋大学大学院医学系研究科)

  1. Matsui, T., Watanabe, T., Matsuzawa, K., Kakeno, M., Okumura, N., Sugiyama, I., Itoh, N., and Kaibuchi, K. (2014). PAR3 and aPKC regulate Golgi organization through CLASP2 phosphorylation to generate cell polarity. Mol Biol Cell, in press
  2. Hamaguchi, T., Nakamuta, S., Funahashi, Y., Takano, T., Nishioka, T., Hasanuzzaman, S.M., Yura, Y., Kaibuchi, K., and Amano, M. (2014). In vivo Screening for Substrates of Protein Kinase A using a combination of proteomic approaches and pharmacological modulation of kinase activity. Cell Struct Funct, in press
  3. Kakeno, M., Matsuzawa, K., Matsui, T., Akita, H., Sugiyama, I., Ishidate, F., Nakano, A., Takashima, S., Goto, H., Inagaki, M., et al. (2014). Plk1 phosphorylates CLIP-170 and regulates its binding to microtubules for chromosome alignment. Cell Struct Funct 39, 45-59.
  4. Funahashi, Y., Namba, T., Fujisue, S., Itoh, N., Nakamuta, S., Kato, K., Shimada, A., Xu, C., Shan, W., Nishioka, T., et al. (2013). ERK2-mediated phosphorylation of Par3 regulates neuronal polarization. J Neurosci 33, 13270-13285.
  5. Wang, S., Watanabe, T., Matsuzawa, K., Katsumi, A., Kakeno, M., Matsui, T., Ye, F., Sato, K., Murase, K., Sugiyama, I., Kimura, K., Mizoguchi, A., Ginsberg, M. H., Collard, J. G., and Kaibuchi, K. (2012). Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration. The Journal of cell biology 199, 331-345.
  6. Nishioka, T., Nakayama, M., Amano, M., and Kaibuchi, K. (2012). Proteomic screening for Rho-kinase substrates by combining kinase and phosphatase inhibitors with 14-3-3zeta affinity chromatography. Cell structure and function 37, 39-48.
  7. Kato, K., Yazawa, T., Taki, K., Mori, K., Wang, S., Nishioka, T., Hamaguchi, T., Itoh, T., Takenawa, T., Kataoka, C., Matsuura, Y., Amano, M., Murohara, T., and Kaibuchi, K. (2012). The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration. Molecular biology of the cell 23, 2593-2604.
  8. Sato, K., Watanabe, T., Wang, S., Kakeno, M., Matsuzawa, K., Matsui, T., Yokoi, K., Murase, K., Sugiyama, I., Ozawa, M., and Kaibuchi, K. (2011). Numb controls E-cadherin endocytosis through p120 catenin with aPKC. Molecular biology of the cell 22, 3103-3119.
  9. Namba, T., Nakamuta, S., Funahashi, Y., and Kaibuchi, K. (2011). The role of selective transport in neuronal polarization. Developmental neurobiology 71, 445-457.
  10. Nakamuta, S., Funahashi, Y., Namba, T., Arimura, N., Picciotto, M. R., Tokumitsu, H., Soderling, T. R., Sakakibara, A., Miyata, T., Kamiguchi, H., and Kaibuchi, K. (2011).Local application of neurotrophins specifies axons through inositol 1,4,5-trisphosphate, calcium, and Ca2+/calmodulin-dependent protein kinases. Science signaling 4, ra76.
  11. Amano, M., Tsumura, Y., Taki, K., Harada, H., Mori, K., Nishioka, T., Kato, K., Suzuki, T., Nishioka, Y., Iwamatsu, A., and Kaibuchi, K. (2010). A proteomic approach for comprehensively screening substrates of protein kinases such as Rho-kinase. PloS one 5, e8704.
  12. Arimura, N., Kimura, T., Nakamuta, S., Taya, S., Funahashi, Y., Hattori, A., Shimada, A., Menager, C., Kawabata, S., Fujii, K., Iwamatsu, A., Segal, R. A., Fukuda, M., and Kaibuchi, K. (2009). Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27. Dev Cell 16, 675-686.
  13. Nakayama, M., Goto, T. M., Sugimoto, M., Nishimura, T., Shinagawa, T., Ohno, S., Amano, M., and Kaibuchi, K. (2008). Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation. Dev Cell 14, 205-215.

A03: 清光 智美(名古屋大学大学院理学研究科)

  1. Kiyomitsu, T.
    Mechanisms of daughter cell-size control during cell division.
    Trends in Cell Biology 25(5):286-295. (2015)
  2. Kiyomitsu, T. and Cheeseman, I.M.
    Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase.
    Cell 154(2):391-402. (2013)
  3. 清光智美
    細胞内の紡錘体配置制御システム
    Intrinsic Regulatory System for the Mitotic Spindle Positioning.
    実験医学増刊号 Vol.31-No.2 (2013)
  4. Kiyomitsu, T. and Cheeseman, I.M.
    Chromosome and spindle pole-derived signals generate an intrinsic code for spindle position and orientation.
    Nature Cell Biology 14(3):311-7 (2012)
  5. Kiyomitsu, T., Murakami, H., and Yanagida, M.
    Protein interaction domain mapping of human kinetochore protein Blinkin reveals a consensus motif for binding of spindle assembly checkpoint proteins Bub1 and BubR1.
    Mol Cell Biol. 31: 998-1011 (2011).
  6. Kiyomitsu, T.*, Iwasaki, O.*, Obuse, C., and Yanagida, M. (* equal contribution)
    Inner centromere formation requires hMis14, a trident kinetochore protein that specifically recruits HP1 to human chromosomes.
    J Cell Biol. 188: 791-807 (2010).

A03: 松村 繁(京都大学ウイルス研究所)

  1. Hamasaki, M., Matsumura, S., Satou, A., Takahashi, C., Oda, Y., Higashiura, C., Ishihama, Y., Toyoshima, F.(2014). Pregnenolone Functions in Centriole Cohesion during Mitosis. Chem Biol. 18, 1707-1721.
  2. Matsumura, S., Hamasaki, M., Yamamoto, T., Ebisuya, M., Sato, M., Nishida, E., and Toyoshima, F. (2012). ABL1 regulates spindle orientation in adherent cells and mammalian skin. Nat. Commun. 3: 626. doi:10.1038/ncomms1634.
  3. Matsumura, S., and Toyoshima, F. (2012). ABL1 joins the cadre of spindle orientation machinery. Cell Struct. Funct. 37, 81-87.
  4. Mitsushima, M., Aoki, K., Ebisuya, M., Matsumura, S., Yamamoto, T., Matsuda, M., Toyoshima, F., and Nishida, E. (2010). Revolving movement of a dynamic cluster of actin filaments during mitosis. J. Cell Biol. doi: 10.1083/jcb.201007136.

A03: 澤本 和延(名古屋市立大学大学院医学研究科)

  1. Yamagishi S, Yamada K, Sawada M, Nakano S, Mori N, Sawamoto K and Sato K (2015) Netrin-5 is highly expressed in neurogenic regions of the adult brain. Front Cell Neurosci9:146. doi: 10.3389/fncel.2015.00146
  2. Zheng LS, Kaneko N and Sawamoto K (2015) Minocycline treatment ameliorates interferon-alpha-induced neurogenic defects and depression-like behaviors in mice. Front Cell Neurosci 9:5. doi: 10.3389/fncel.2015.00005
  3. Ajioka I, Jinnou H, Okada K, Sawada M, Saitoh S, Sawamoto K (2015) Enhancement of neuroblast migration into the injured cerebral cortex using laminin-containing porous sponge. Tissue Eng Part A 21: 193-201.
  4. Ota H, Hikita T, Sawada M, Nishioka T, Matsumoto M, Komura M, Ohno A, Kamiya Y, Miyamoto T, Asai N, Enomoto A, Takahashi M, Kaibuchi K, Sobue K, Sawamoto K (2014) Speed control for neuronal migration in the postnatal brain by Gmip-mediated local inactivation of RhoA. Nat Commun 5: 4532. DOI: 10.1038/ncomms5532
  5. Zheng LS, Hitoshi S, Kaneko N, Takao K, Miyakawa T, Tanaka Y, Xia H, Kalinke U, Kudo K, Kanba S, Ikenaka K, Sawamoto K (2014) Mechanisms for interferon-alpha-induced depression and neural stem cell dysfunction. Stem Cell Rep 3: 73-84.?DOI:http://dx.doi.org/10.1016/j.stemcr.2014.05.015
  6. Hikita T, Ohno A, Sawada M, Ota H, Sawamoto K (2014) Rac1-mediated indentation of resting neurons promotes the chain migration of new neurons in the rostral migratory stream of postnatal mouse brain. J Neurochem 128: 790-797. DOI: 10.1111/jnc.12518
  7. Sawada M, Matsumoto M, Sawamoto K (2014) Vascular regulation of adult neurogenesis under the physiological and pathological conditions. Front Neurosci 8:53. doi: 10.3389/fnins.2014.00053
  8. Ota H, Hikita T, Nishioka T, Matsumoto M, Ito J, Asai N, Enomoto A, Takahashi M, Kaibuchi K, Sobue K, Sawamoto K (2013) Proteomic analysis of Girdin-interacting proteins in migrating new neurons in the postnatal mouse brain. Biochem Biophys Res Commun442: 16-21.
  9. Kishimoto N, Asakawa K, Madelaine R, Blader P, Kawakami K, Sawamoto K (2013) Interhemispheric asymmetry of olfactory input-dependent neuronal specification in the adult brain. Nat Neurosci 16: 884-888.
  10. Kaneko N, Kako E, Sawamoto K (2013) Enhancement of ventricular-subventricular zone-derived neurogenesis and oligodendrogenesis by erythropoietin and its derivatives. Front Cell Neurosci 7:235. doi: 10.3389/fncel.2013.00235
  11. Sawada M and Sawamoto K (2013) Mechanisms of neurogenesis in the normal and injured adult brain. Keio J Med 62:13-28.
  12. Kato Y, Kaneko N, Sawada M, Ito K, Arakawa S, Murakami S, Sawamoto K (2012) A subtype-specific critical period for neurogenesis in the postnatal development of mouse olfactory glomeruli. PLoS ONE 7 (11): e48431. doi: 10.1371/journal.pone.0048431.
  13. Nakaguchi K, Jinnou H, Kaneko N, Sawada M, Hikita T, Saitoh S, Tabata Y, Sawamoto K (2012) Growth factors released from gelatin hydrogel microspheres increase new neurons in the adult mouse brain. Stem Cells Int 2012, Article ID 915160, 7 pages, doi: 10.1155/2012/915160.
  14. Kako E, Kaneko N, Aoyama M, Hida H, Takebayashi H, Ikenaka K, Asai K, Togari H, Sobue K, Sawamoto K (2012) Subventricular-zone derived oligodendrogenesis in injured neonatal white-matter in mice enhanced by a nonerythropoietic EPO derivative. Stem Cells 30: 2234-2247.
  15. Hirota Y, Sawada M, Kida YS, Huang S, Yamada O, Sakaguchi M, Ogura T, Okano H, Sawamoto K (2012) Roles of planar cell polarity signaling in maturation of neuronal precursor cells in the postnatal mouse olfactory bulb. Stem Cells 30: 1726-1733.
  16. Kishimoto N, Shimizu K, Sawamoto, K (2012) Neuronal regeneration in a zebrafish model of adult brain injury. Dis Models Mech 5: 200-209.
  17. Shinohara R, Thumkeo D, Kamijo H, Kaneko N, Sawamoto K, Watanabe K, Takebayashi H, Kiyonari H, Ishizaki T, Furuyashiki T, Narumia S (2012) A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors. Nat Neurosci 15: 373-380.
  18. Kishimoto N and Sawamoto K (2012) Planar polarity of ependymal cilia. Differentiation83: S86-S90.
  19. Sawada M, Kaneko N, Inada H, Wake H, Kato Y, Yanagawa Y, Kobayashi K, Nemoto T, Nabekura J, Sawamoto K (2011) Sensory input regulates spatial and subtype-specific patterns of neuronal turnover in the adult olfactory bulb. J Neurosci31:11587-11596.
  20. Kishimoto N, Alfaro-Cervello C, Shimizu K, Asakawa K, Urasaki A, Nonaka S, Kawakami K, Garcia-Verdugo JM, Sawamoto K (2011) Migration of neuronal precursors from the telencephalic ventricular zone into the olfactory bulb in adult zebrafish. J Comp Neurol519:3549-3565.
  21. Sawamoto K, Hirota Y, Alfaro-Cervello C, Soriano-Navarro M, He X, Hayakawa-Yano Y, Yamada M, Hikishima K, Tabata H, Iwanami A, Nakajima K, Toyama Y, Itoh T, Alvarez-Buylla A, Garcia-Verdugo JM, Okano H (2011) Cellular composition and organization of the subventricular zone and rostral migratory stream in the adult and neonatal common marmoset brain. J Comp Neurol 519:690-713.
  22. Sawada M, Huang S, Hirota Y, Kaneko N, Sawamoto K (2011) Neuronal migration in the adult brain. Neurogenesis in the adult brain. (Edited by Seki T, Sawamoto K, Parent J, Alvarez-Buylla A) Springer
  23. Nakaguchi K, Masuda H, Kaneko N, Sawamoto K (2011) Strategies for regenerating striatal neurons in the adult brain by using endogenous neural stem cells. Neurol Res Int2011:898012.
  24. Kaneko N, Kako E, Sawamoto K (2011) Prospects and limitations of using endogenous neural stem cells for brain regeneration. Genes 2011(2): 107-130.
  25. Oki K, Kaneko N, Kanki H, Imai T, Suzuki N, Sawamoto K, Okano H (2010) Musashi1 as a marker of reactive astrocytes after transient focal brain ischemia. Neurosci Res 66:390-395.
  26. Kojima T, Hirota Y, Ema M, Takahashi S, Miyoshi I, Okano H, Sawamoto K (2010) Subventricular zone-derived neural progenitor cells migrate along a blood vessel scaffold toward the post-stroke striatum. Stem Cells 28:545-554.
  27. Kaneko N, Marin O, Koike M, Hirota Y, Uchiyama Y, Wu JY, Lu Q, Tessier-Lavigne M, Alvarez-Buylla A, Okano H, Rubenstein JL, Sawamoto K (2010) New Neurons Clear the Path of Astrocytic Processes for Their Rapid Migration in the Adult Brain. Neuron 67:213-223.
  28. Ikeda M, Hirota Y, Sakaguchi M, Yamada O, Kida YS, Ogura T, Otsuka T, Okano H, Sawamoto K (2010) Expression and Proliferation-Promoting Role of Diversin in the Neuronally Committed Precursor Cells Migrating in the Adult Mouse Brain. Stem Cells28:2017-2026.
  29. Hirota Y, Meunier A, Huang S, Shimozawa T, Yamada O, Kida YS, Inoue M, Ito T, Kato H, Sakaguchi M, Sunabori T, Nakaya MA, Nonaka S, Ogura T, Higuchi H, Okano H, Spassky N, Sawamoto K (2010) Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin II. Development 137:3037-3046.
  30. Guirao B, Meunier A, Mortaud S, Aguilar A, Corsi JM, Strehl L, Hirota Y, Desoeuvre A, Boutin C, Han YG, Mirzadeh Z, Cremer H, Montcouquiol M, Sawamoto K, Spassky N (2010) Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile cilia. Nat Cell Biol 12:341-350.

A03: 廣田 ゆき(慶應義塾大学医学部)

  1. Hirota, Y., Kubo, K., Katayama, K., Honda, T., Fujino, T., Yamamoto, T., Nakajima, K. Reelin receptors ApoER2 and VLDLR are expressed in distinct spatio-temporal patterns in developing mouse cerebral cortex. J. Comp. Neurol. 523, 463-478. 2015.
  2. *Ishii, K., *Nagai, T., *Hirota, Y., Noda, M., Nabeshima, T., Yamada, K., Kubo, K., Nakajima, K. Reelin has a preventive effect on phencyclidine-induced cognitive and sensory-motor gating deficits. Neurosci. Res. 96, 30–36. 2015. *equal contribution.
  3. Hirota, Y., Sawada, M., Kida, YS., Huang, SH., Yamada, O., Sakaguchi, M., Ogura, T., Okano, H., Sawamoto, K. Roles of planar cell polarity signaling in maturation of neuronal precursor cells in the postnatal mouse olfactory bulb. Stem Cells, 30, 1726-33. 2012.
  4. *Sawamoto, K., *Hirota, Y*., *Alfaro-Cervello, C., *Soriano-Navarro, M., He, X., Hayakawa-Yano, Y., Yamada, M., Hikishima, K., Tabata, H., Iwanami, A., Nakajima, K., Toyama, Y., Itoh, T., Alvarez-Buylla, A., Garcia-Verdugo, JM., and Okano, H. Cellular composition and organization of the subventricular zone and rostral migratory stream in the adult and neonatal common marmoset brain. J. Comp. Neurol. 519, 690-713. 2011. *equal contribution.