文部科学省科学研究費補助金「新学術領域研究」 シリア・中心体系による生体情報フローの制御

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研究業績

計画班公募班(平成27-28年度)|公募班(平成25-26年度)

公募班(平成25-26年度)

A01: 水野 健作(東北大学大学院生命科学研究科)

  1. Oda, T., Chiba, S., Nagai, T., and Mizuno, K. (2014). Binding to Cep164, but not EB1, is essential for centriolar localization of TTBK2 and its function in ciliogenesis. Genes Cells 19, 927-940.
  2. Ohashi, K., Sampei, K., Nakagawa, M., Uchiumi, N., Amanuma, T., Aiba, S., Oikawa, M., and Mizuno, K. (2014). Damnacanthal, an effective inhibitor of LIM-kinase, inhibits cell migration and invasion. Mol. Biol. Cell 25, 828-840.
  3. Homma, Y., Kanno, S. I., Sasaki, K., Nishita, M., Yasui, A., Asano, T., Ohashi, K., and Mizuno, K. (2014). Insulin receptor substrate-4 binds to Slingshot-1 phosphatase and promotes cofilin dephosphorylation. J. Biol. Chem. 289, 26302-26313.
  4. Nagai, T., and Mizuno, K. (2014). Multifaceted roles of Furry proteins in invertebrates and vertebrates. J. Biochem. 155, 137-146.
  5. Nagai, T., Ikeda, M., Chiba, S., Kanno, S., and Mizuno, K. (2013). Furry promotes acetylation of microtubules in the mitotic spindle by inhibition of SIRT2 tubulin deacetylase. J. Cell Sci. 126, 4369-4380.
  6. Chiba, S., Amagai, Y., Homma, Y., Fukuda, M., and Mizuno, K. (2013). NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15. EMBO J. 32, 874-885.
  7. Higashida, C., Kiuchi, T., Akiba, Y., Mizuno, H., Maruoka, M., Narumiya, S., Mizuno, K., and Watanabe, N. (2013). F- and G-actin homeostasis regulates mechanosensitive actin nucleation by formins. Nat. Cell Biol. 15, 395-405.
  8. Borroni, E. M., Cancellieri, C., Vacchini, A., Benureau, Y., Lagane, B., Bachelerie, F., Arenzana-Seisdedos, F., Mizuno, K., Mantovani, A., Bonecchi, R., and Locati, M. (2013). β-Arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6. Sci. Signal. 6, ra30.
  9. Mizuno, K. (2013). Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation. Cell. Signal. 25, 457-469.
  10. Hou, X., Katahira, T., Ohashi, K., Mizuno, K., Sugiyama, S, and Nakamura, H. (2013). Coactosin accelerates cell dynamism by promoting actin polymerization. Dev. Biol. 379, 53-63.
  11. Ikeda, M., Chiba, S., Ohashi, K., and Mizuno, K. (2012). Furry protein promotes Aurora A-mediated Polo-like kinase 1 activation. J. Biol. Chem. 287, 27670-27681.
  12. Ohashi, K., Kiuchi, T., Shoji, K., Sampei, K., and Mizuno, K. (2012). Visualization of cofilin-actin and Ras-Raf interactions by bimolecular fluorescence complementation assays using a new pair of split Venus fragments. BioTechniques 52, 45-50.
  13. Nishio, M., Hamada, K., Kawahara, K., Sasaki, M., Noguchi, F., Chiba, S., Mizuno, K., Suzuki, S. O., Dong, Y., Tokuda, M., Morikawa, T., Hikasa, H., Eggenschwiler, J., Yabuta, N., Nojima, H., Nakagawa, K., Hata, Y., Nishina, H., Mimori, K., Mori, M., Sasaki, T., Mak, T. W., Nakano, T., Itami, S., and Suzuki, A. (2012). Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J. Clin. Invest. 122, 4505-4518.
  14. Kiuchi, T., Nagai, T., Ohashi, K., and Mizuno, K. (2011). Measurements of spatiotemporal changes in G-actin concentration reveal its effect on stimulus-induced actin assembly and lamellipodium extension. J. Cell Biol. 193, 365-380.
  15. Ohashi, K., Fujiwara, S., Watanabe, T., Kondo, H., Kiuchi, T., Sato, M., and Mizuno, K. (2011). LIM-kinase has a dual role in regulating lamellipodium extension by decelerating the rate of actin retrograde flow and the rate of actin polymerization. J. Biol. Chem. 286, 36340-36351.
  16. Itoh, G., Kanno, S., Uchida, K. S. K., Chiba, S., Sugino, S., Watanabe, K., Mizuno, K., Yasui, A., Hirota, T., and Tanaka, K. (2011). CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment. EMBO J. 30, 130-144.
  17. Tsuji, T., Ohta, Y., Kanno, Y., Hirose, K., Ohashi, K., and Mizuno, K. (2010). Involvement of p114-RhoGEF and Lfc in Wnt-3a- and Dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells. Mol. Biol. Cell 21, 3590-3600.
  18. Xiao, K., Sun, J., Kim, J., Rajagopal, S., Zhai, B., Villen, J., Haas, W., Kovacs, J. J., Shukla, A. K., Hara, M., Hernandez, M., Lachmann, A., Zhao, S., Lin, Y., Cheng, Y., Mizuno, K., Ma'ayan, A., Gygi, S. P., and Lefkowitz, R. J. (2010). Global phosphorylation analysis of β-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc. Natl. Acad. Sci. U.S.A. 107, 15299-15304.
  19. Chiba, S., Ikeda, M., Katsunuma, K., Ohashi, K., and Mizuno, K. (2009). MST2- and Furry-mediated activation of NDR1 is critical for precise alignment of mitotic chromosomes. Curr. Biol. 19, 675-681.
  20. Eiseler, T., Doppler, H., Yan, I. K., Kitatani, K., Mizuno, K., and Storz, P. (2009). Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through Slingshot. Nat. Cell Biol. 11, 545-556.

A01: 広野 雅文(東京大学大学院理学系研究科)

  1. Arakaki, Y., Kawai-Toyooka, H., Hamamura, Y., Higashiyama, T., Noga, A., Hirono, M., Olson, B.J., Nozaki, H. (2013). The simplest integrated multicellular organism unveiled. PLoS One 8, e81641.
  2. Ishikawa, H., Ide, T., Yagi, T., Jiang, X., Hirono, M., Sasaki, H., Yanagisawa, H., Wemmer, K.A., Stainier, D.Y., Qin, H., Kamiya, R., Marshall, W.F. (2014). TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella. eLife 3, e01566.
  3. Hirono, M. (2014). Cartwheel assembly. Philos. Trans. R. Soc. Lond. B Biol. Sci. 369, pii: 20130458 (Issue of "Centrosome Renaissance")
  4. Kubo, T., Yanagisawa, H.A., Liu, Z., Shibuya, R., Hirono, M., Kamiya, R. (2014). A conserved flagella-associated protein in Chlamydomonas, FAP234, is essential for axonemal localization of tubulin polyglutamylase TTLL9. Mol. Biol. Cell 25, 107-117.
  5. Yanagisawa, H.A., Mathis, G., Oda, T., Hirono, M., Richey, E.A., Ishikawa, H., Marshall, W.F., Kikkawa, M., Qin, H. (2014). FAP20 is an inner junction protein of doublet microtubules essential for both the planar asymmetrical waveform and stability of flagella in Chlamydomonas. Mol. Biol. Cell 25, 1472-1483.
  6. Wang, L., Yamano, T., Kajikawa, M., Hirono, M., Fukuzawa, H. (2014). Isolation and characterization of novel high-CO2-requiring mutants of Chlamydomonas reinhardtii. Photosynth. Res. 121, 175-184.
  7. Nakazawa, Y., Ariyoshi, T., Noga, A., Kamiya, R., and Hirono, M. (2014). Space-dependent formation of central pair microtubules and their interactions with radial spokes. PLoS One 9, pii: e110513.
  8. Yamamoto, R., Hirono, M., and Kamiya, R. (2010). Discrete PIH proteins function in the cytoplasmic preassembly of different subsets of axonemal dyneins. J. Cell Biol. 190, 65-71.
  9. Kubo, T., Yanagisawa, H., Yagi, T., Hirono, M., and Kamiya, R. (2010). Tubulin polyglutamylation regulates axonemal motility by modulating activities of inner-arm dyneins. Curr. Biol. 20, 441-445.
  10. Shiratsuchi, G., Kamiya, R., and Hirono, M. (2011). Scaffolding function of the Chlamydomonas procentriole protein CRC70, a member of the conserved Cep70 family. J. Cell Sci. 124, 2964-2975.
  11. van Breugel, M., Hirono, M., Andreeva, A., Yanagisawa, H. A., Yamaguchi, S., Nakazawa, Y., Morgner, N., Petrovich, M., Ebong, I. O., Robinson, C. V., Johnson, C. M., Veprintsev, D., Zuber, B. (2011). Structures of SAS-6 suggest its organization in centrioles. Science. 331, 1196-1199.
  12. Engel, B. D., Ishikawa, H., Wemmer, K. A., Geimer, S., Wakabayashi, K., Hirono, M., Craige, B., Pazour, G. j., Witman, G. B., Kamiya, R., Marshall, W. F. (2012). The role of retrograde intraflagellar transport in flagellar assembly and function. J. Cell Biol. 199, 151-167.
  13. Yamamoto,R., Song,K., Yanagisawa,H., Fox,L., Yagi,T., Wirschell,M., Hirono,M., Kamiya,R., Nicastro,D., and Sale, W. S. (2013). The MIA complex is a conserved and novel dynein regulator essential for normal ciliary motility. J. Cell Biol. 201, 263-278.

A01: 豊島 陽子(東京大学大学院総合文化研究科)

  1. Furuta, K., Furuta, A., Toyoshima, Y.Y., Amino, M., Oiwa, K., and Kojima, H. (2013). Measuring collective transport by defined numbers of processive and nonprocessive kinesin motors. Proc Natl Acad Sci U S A. 110, 501-6.
  2. Shibata, K., Miura, M., Watanabe, Y., Saito, K., Nishimura, A., Furuta, K. and Toyoshima, Y. Y. (2012). A Single Protofilament Is Sufficient to Support Unidirectional Walking of Dynein and Kinesin. PLoS One. 7, e42990.
  3. Toyoshima, Y. Y. and Higuchi, H. (2012). Motile and enzymatic properties of native dynein molecules. Handbook of Dynein pp123-144. (eds. Hirose, K. and Amos, L., Pan Stanford Publishing)
  4. Shapasand, K., Uemura, I., Saito, T., Asano, T., Hata, K., Shibata, K., Toyoshima, Y. Y., Hasegawa, M. & Hisanaga, S. (2012). Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylation in Alzheimer’s disease. J. Neurosci., 32, 2430-2441.
  5. Kitai, T., Watanabe, Y., Toyoshima, Y. Y., Kobayashi, T., Murayama, T., Sakaue, H., Suzuki, H., and Takahagi, T. (2011). Simple method of synthesizing nickel-nitrilotriacetic acid gold nanoparticles with a narrow size distribution for protein labeling. Jap. J. Appl.Phys. 50, 0950021-095024.
  6. Ichikawa, M., Watanabe, Y., Murayama, T., and Toyoshima, Y. Y. (2011). Recombinant human cytoplasmic dynein heavy chain 1 and 2: Observation of dynein-2 motor activity in vitro. FEBS Lett. 585, 2419-2423.
  7. Torisawa, T., Nakayama, A., Furuta, K., Yamada, M., Hirotsune, S. and Toyoshima, Y. Y. (2011). Functional Dissection of LIS1 and NDEL1 Towards Understanding the Molecular Mechanisms of Cytoplasmic Dynein Regulation. J. Biol.Chem. 286, 1959-1965.
  8. Miura, M., Matsubara, A., Kobayashi, T., Edamatsu, M., and Toyoshima, Y. Y. (2010). Nucleotide-dependent behavior of single molecules of cytoplasmic dynein on microtubules in vitro. FEBS Lett. 584, 2351-2355.
  9. Arimura, N., Hattori, A., Kimura, T., Nakamura , S., Funahashi, Y., Hirotsune, S., Furuta, K., Toyoshima, Y. Y., and Kaibuchi, K. (2009). Inhibition of cytoplasmic dynein activity by CRMP-2 through a direct interaction. J Neurochem. 111, 380-390.
  10. Furuta, K. and Toyoshima, Y. Y. (2008). Diffusion and directed movement: In vitro motile properties of fission yeast kinesin-14 Pkl1. J. Biol.Chem. 283, 36465-36473.
  11. Taba, T., Edamatsu, M., Toba, S., Shibata, K., Imafuku, Y., Toyoshima, Y.Y., Tawada, K., and Yamada, A. (2008). Direction and speed of microtubule movements driven by kinesin motors arranged on catchin thick filaments. Cell Motility and the Cytoskeleton 65, 816-826.
  12. Shimizu, Y., Kato, Y., Morii, H., Edamatsu, M., Toyoshima, Y.Y, Tanokura, M. (2008). The dynein stalk head, the microtubule binding-domain of dynein: NMR assignment and ligand binding. J. Biomol. NMR 41, 89-96.
  13. Furuta, K. and Toyoshima, Y. Y. (2008). Minus-end-directed motor Ncd exhibits processive movement that is enhanced by microtubule bundling in vitro. Current Biology 18, 152-157.

A01: 塚原 達也(東京大学大学院理学系研究科)

  1. Nishimura T, Herpin A, Kimura T, Hara I, Kawasaki T, Nakamura S, Yamamoto Y, Saito TL, Yoshimura J, Morishita S, Tsukahara T, Kobayashi S, Naruse K, Shigenobu S, Sakai N, Schartl M, Tanaka M. (2014). Analysis of a novel gene, Sdgc, reveals sex chromosome-dependent differences of medaka germ cells prior to gonad formation. Development, 141, 3363-3369
  2. Nakamura R, Tsukahara T, Qu W, Otsuka T, Ogoshi K, Saito TL, Matsushima K, Sugano S, Hashimoto S, Suzuki Y, Morishita S, Takeda H. (2014). Large DNA hypomethylated domain as a repressive platform of key transcription factors in vertebrates. Development, 141, 2568-2580, 2014
  3. Tsukahara T, Tanno Y and Watanabe Y. (2010). Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation. Nature 467, 719-723.
  4. Omran H, Kobayashi D, Olbrich H, Tsukahara T, Loges NT, Hagiwara H, Zhang Q, Leblond G, O’Toole E, Hara C, Mizuno H, Kawano H, Fliegauf M, Yagi T, Koshida S, Miyawaki A, Zentgraf H, Seithe H, Reinhardt R, Watanabe Y, Kamiya R, Mitchell DR and Takeda H.(2008). Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins. Nature (article) 456, 611-616.
  5. Moriyama Y, Kawanishi T, Nakamura R, Tsukahara T, Sumiyama K, Suster ML, Kawakami K, Toyoda A, Fujiyama A, Yasuoka Y, Nagao Y, Sawatari E, Shimizu A, Wakamatsu Y, Hibi M, Taira M, Okabe M, Naruse K, Hashimoto H, Shimada A, Takeda H. (2012).The Medaka zic1/zic4 Mutant Provides Molecular Insights into Teleost Caudal Fin Evolution. Current Biology 22, 601-607.
  6. Kagami A, Sakuno T, Yamagishi Y, Ishiguro T, Tsukahara T, Shirahige K, Tanaka K and Watanabe Y. (2011). Acetylation regulates monopolar attachment at several levels during meiosisI in fission yeast. EMBO reports 12, 1189-1195.
  7. Hauf S, Biswas A, Langegger M, Kawashima SA, Tsukahara T and Watanabe Y. (2007). Aurora controls sister kinetochore mono-orientation and homolog bi-orientation in meiosis-I. EMBO journal 26, 4475-4486.
  8. Kawashima SA, Tsukahara T, Langegger M, Hauf S, Kitajima TS and Watanabe Y. (2007). Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres. Genes & Development 21, 420-435.
  9. Hojo M, Takashima S, Kobayashi D, Sumeragi A, Shimada A, Tsukahara T, Yokoi H, Narita T, Jindo T, Kage T, Kitagawa T, Kimura T, Sekimizu K, Miyake A, Setiamarga D, Murakami R, Tsuda S, Ooki S, Kakihara K, Naruse K, Takeda H. (2007). Right-elevated expression of charon is regulated by fluid flow in medaka Kupffer's vesicle. Development, Growth and Differentiation 49, 395-405.

A01: 荒川 聡子(東京医科歯科大学 難治疾患研究所)

  1. Honda S, Arakawa S, Nishida Y, Yamaguchi H, Ishii E, and Shimizu S. (2014). Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes, Nature Commun. 5:4004.
  2. Shimizu S, Honda S, Arakawa S, Yamaguchi H. (2014). Alternative macroautophagy and mitophagy. Int J Biochem Cell Biol. 50, 64-66.
  3. Shimizu S, Yoshida T, Tsujioka M, Arakawa S. (2014). Autophagic cell death and cancer. Int J Mol Sci. 15, 3145-3153.
  4. Mizushima T, Arakawa S, Sanada Y, Yoshino I, Miyazaki D, Urushima H, Tsujimoto Y, Ito T, S. Shimizu. (2013). Inhibition of epithelial cell death by Bcl-2 improved chronic colitis in IL-10 KO mice. Am J Pathol. 183, 1936-1944.
  5. Nakase, I., Okumura, S., Katayama, S., Hirose, H., Pujals, S., Yamaguchi, H., Arakawa, S., Shimizu, S., Futaki, S.. (2012). Transformation of an antimicrobial peptide into a plasma membrane-permeable, mitochondria-targeted peptide via the substitution of lysine with arginine. Chem Commun (Camb) 48(90):11097-9.
  6. Miyaoka, Y., Ebato, K., Kato, H., Arakawa, S., Shimizu, S., Miyajima, A.. (2012). Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration. Curr Biol. 22(13):1166-75.
  7. Konishi, A., Arakawa, S., Yue, Z., Shimizu, S. (2012). Involvement of Beclin 1 in engulfment of apoptotic cells. J Biol Chem. 287(17):13919-29.
  8. Fukumatsu, M., Ogawa, M., Arakawa, S., Suzuki, M., Nakayama, K., Shimizu, S., Kim, M., Mimuro, H., Sasakawa, C. (2012). Shigella targets epithelial tricellular junctions and uses a noncanonical clathrin-dependent endocytic pathway to spread between cells. Cell Host Microbe 11(4):325-36.
  9. Yamasaki, T., Kawasaki, H., Arakawa, S., Shimizu, K., Shimizu, S., Reiner, O., Okano, H., Nishina, S., Azuma, N., Penninger, JM., Katada, T., Nishina, H. (2011). Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex. J Neurosci. 31(46):16872-83.
  10. Narita, M., Young, AR., Arakawa, S., Samarajiwa, SA., Nakashima, T., Yoshida, S., Hong, S., Berry, LS/, Reichelt, S/, Ferreira, M/, Tavare, S/, Inoki, K/, Shimizu, S., Narita, M. (2011). Spatial coupling of mTOR and autophagy augments secretory phenotypes. Science 332(6032):966-70.
  11. Kamiya, K., Tsumoto, K., Arakawa, S., Shimizu, S., Morita, I., Yoshimura, T., Akiyoshi, K.. (2010). Preparation of connexin43-integrated giant Liposomes by a baculovirus expression-liposome fusion method. Biotechnol Bioeng 107(5):836-43.
  12. Nabeyama, A., Kurita, A., Asano, K., Miyake, Y., Yasuda, T., Miura, I., Nishitai, G., Arakawa, S., Shimizu, S., Wakana, S., Yoshida, H., Tanaka, M. (2010). xCT deficiency accelerates chemically induced tumorigenesis. Proc Natl Acad Sci U S A. 107(14):6436-41.
  13. Nishida, Y., Arakawa, S., Fujitani, K., Yamaguchi, H., Mizuta, T., Kanaseki, T., Komatsu, M., Otsu, K., Tsujimoto, Y., Shimizu, S.. (2009). Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature 461(7264):654-8.
  14. Young, AR., Narita, M., Ferreira, M., Kirschner, K., Sadaie, M., Darot, JF., Tavare, S., Arakawa, S., Shimizu, S., Watt, FM., Narita, M.. (2009). Autophagy mediates the mitotic senescence transition. Genes Dev. 23(7):798-803.

A01: 中山 和久(京都大学大学院薬学研究科)

  1. Takatsu, H., Tanaka, G., Segawa, K., Suzuki, J., Nagata, S., Nakayama, K. & Shin, H.-W. (2014). Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane. J. Biol. Chem., 289, 33543-33556.
  2. Nakazawa, S., Sakanaka, M., Furuta, K., Natsuhara, M., Takano, H., Tsuchiya, S., Okuno, Y., Ohtsu, H., Nishibori, M., Thurmond, R.L., Hirasawa, N., Nakayama, K., Ichikawa, A., Sugimoto, Y. & Tanaka, S. (2014). Histamine synthesis is required for granule maturation in murine mast cells. Eur. J. Immunol., 44, 204-214.
  3. Nakai, W., Kondo, Y., Saitoh, A., Naito, T., Nakayama, K. & Shin, H.-W. (2013). ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus. Mol. Biol. Cell 24, 2570-2581.
  4. Ueda, T., Hanai, A., Takei, T., Kubo, K., Ohgi, M., Sakagami, H., Takahashi, S., Shin, H.-W. & Nakayama, K. (2013). EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis. FEBS Lett. 587, 1617-1623.
  5. Takatsu, H., Katoh, Y., Ueda, T., Waguri, S., Murayama, T., Takahashi, S., Shin, H.-W. & Nakayama, K. (2013). Mitosis-coupled, microtubule-dependent clustering of endosomal vesicles around centrosomes. Cell Struct. Funct. 38, 31-41.
  6. Kondo, Y., Hanai, A., Nakai, W., Katoh, Y., Nakayama, K. & Shin, H.-W. (2012). ARF1 and ARF3 are required for the integrity of recycling endosomes and the recycling pathway. Cell Struct. Funct. 37, 141-154.
  7. Nakamura, K., Man, Z., Xie, Y., Hanai, A., Makyio, H., Kawasaki, M., Kato, R., Shin, H.-W., Nakayama, K. & Wakatsuki, S. (2012). Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase. J. Biol. Chem. 287, 25478-25489.
  8. Takahashi, S., Kubo, K., Waguri, S., Yabashi, A., Shin, H.-W., Katoh, Y. & Nakayama, K. (2012). Rab11 regulates exocytosis of recycling vesicles at the plasma membrane. J. Cell Sci. 125, 4049-4057.
  9. Makyio, H., Ohgi, M., Takei, T., Takahashi, S., Takatsu, H., Katoh, Y., Hanai, A., Ueda, T., Kanaho, Y., Xie, Y., Shin, H.-W., Kamikubo, H., Kataoka, M., Kawasaki, M., Kato, R., Wakatsuki, S. & Nakayama, K. (2012). Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis. EMBO J. 31, 2590-2603.
  10. Fukumatsu, M., Ogawa, M., Arakawa, S., Suzuki, M., Furuse, M., Nakayama, K., Shimizu, S., Kim, M., Mimuro, H. & Sasakawa, C. (2012). Shigella targets epithelial tricellular junctions and uses a noncanonical clathrin-dependent endocytic pathway to spread between cells. Cell Host Microbe 11, 325-336.
  11. Takano, H., Furuta, K., Yamashita, K., Sakanaka, M., Itano, N., Gohda, E., Nakayama, K., Kimata, K., Sugimoto, Y., Ichikawa, A. & Tanaka, S. (2012). Restriction of mast cell proliferation through hyaluronan synthesis by co-cultured fibroblasts. Biol. Pharm. Bull. 35, 408-412.
  12. Takashima, K., Saitoh, A., Hirose, S., Nakai, W., Kondo, Y., Takasu, Y., Kakeya, H., Shin, H.-W. & Nakayama, K. (2011). GBF1-Arf-COPI-ArfGAP-mediated Golgi-to-ER transport involved in regulation of lipid homeostasis. Cell Struct. Funct. 36, 223-235.
  13. Takatsu, H., Baba, K., Shima, T., Umino, H., Kato, U., Umeda, M., Nakayama, K. & Shin, H.-W. (2011). ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50-independent manner. J. Biol. Chem. 286, 38159-38167.
  14. Takahashi, S., Takei, T., Koga, H., Takatsu, H., Shin, H.-W. & Nakayama, K. (2011). Distinct roles of Rab11 and Arf6 in the regulation of Rab11-FIP3/Arfophilin-1 localization in mitotic cells. Genes Cells 16, 938-950.
  15. Man, Z., Kondo, Y., Koga, H., Umino, H., Nakayama, K. & Shin, H.-W. (2011). Arfaptins are localized to the trans-Golgi by interaction with Arl1, but not Arfs. J. Biol. Chem. 286, 11569-11578.
  16. Yamamoto, H., Koga, H., Katoh, Y., Takahashi, S., Nakayama, K. & Shin, H.-W. (2010). Functional crosstalk between Rab14 and Rab4 through a dual effector, RUFY1/Rabip4. Mol. Biol. Cell 21, 2746-2755.
  17. Saitoh, A., Shin, H.-W., Yamada, A., Waguri, S. & Nakayama, K. (2009). Three homologous ArfGAPs participate in coat protein I-mediated transport. J. Biol. Chem. 284, 13948-13957.
  18. Nishimoto-Morita, K., Shin, H.-W., Mitsuhashi, H., Kitamura, M., Zhang, Q., Johannes, L. & Nakayama, K. (2009). Differential effects of depletion of ARL1 and ARFRP1 on membrane trafficking between the trans-Golgi network and endosomes. J. Biol. Chem. 284, 10583-10592.
  19. Azuma, Y., Takada, M., Shin, H.-W., Kioka, N., Nakayama, K. & Ueda, K. (2009). The retroendocytosis pathway of ABCA1/apoA-I contributes to HDL formation. Genes Cells 14, 191-204.
  20. Takano, H., Nakazawa, S., Shirata, N., Tamba, S., Furuta, K., Tsuchiya, S., Morimoto, K., Itano, N., Irie, A., Ichikawa, A., Kimata, K., Nakayama, K., Sugimoto, Y. & Tanaka, S. (2009). Involvement of CD44 in mast cell proliferation during terminal differentiation. Lab. Invest. 89, 446-455.
  21. Ishizaki, R., Shin, H.-W., Mitsuhashi, H. & Nakayama, K. (2008). Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ARFs, in membrane traffic between the TGN and endosomes. Mol. Biol. Cell 19, 2650-2660.

A01: 藤原 敬宏(京都大学 物質-細胞統合システム拠点)

  1. Hiramoto-Yamaki, N., Tanaka, K.A., Suzuki, K.G., Hirosawa, K.M., Miyahara, M.S., Kalay, Z., Tanaka, K., Kasai, R.S., Kusumi, A., and Fujiwara, T.K. (2014). Ultrafast diffusion of a fluorescent cholesterol analog in compartmentalized plasma membranes. Traffic 15, 583-612.
  2. Kalay, Z., Fujiwara, T.K., Otaka, A., and Kusumi, A. (2014). Lateral diffusion in a discrete fluid membrane with immobile particles. Phys. Rev. E 89, 022724.
  3. Imayoshi, I., Isomura, A., Harima, Y., Kawaguchi, K., Kori, H., Miyachi, H., Fujiwara, T., Ishidate, F., and Kageyama, R. (2013). Oscillatory control of factors determining multipotency and fate in mouse neural progenitors. Science 342, 1203-1208.
  4. Yoshikawa, N., Hirori, H., Watanabe, H., Aoki, T., Ihara, T., Kusuda, R., Wolpert, C., Fujiwara, T.K., Kusumi, A., Kanemitsu, Y., and Tanaka, K. (2013). Biexciton state causes photoluminescence fluctuations in CdSe/ZnS core/shell quantum dots at high photoexcitation densities. Phys. Rev. B 88, 155440.
  5. Nishimura, H., Ritchie, K., Kasai, R.S., Goto, M., Morone, N., Sugimura, H., Tanaka, K., Sase, I., Yoshimura, A., Nakano, Y., Fujiwara, T.K., and Kusumi, A. (2013). Biocompatible fluorescent silicon nanocrystals for single-molecule tracking and fluorescence imaging. J. Cell Biol. 202, 967-983.
  6. Koyama-Honda, I., Itakura, E., Fujiwara, T.K., and Mizushima, N. (2013). Temporal analysis of recruitment of mammalian ATG proteins to the autophagosome formation site. Autophagy 9, 1491-1499.
  7. Takamatsu, S., Onoguchi, K., Onomoto, K., Narita, R., Takahasi, K., Ishidate, F., Fujiwara, T.K., Yoneyama, M., Kato, H., and Fujita, T. (2013). Functional characterization of domains of IPS-1 using an inducible oligomerization system. PLoS One 8, e53578.
  8. Shibata, A.C., Chen, L.H., Nagai, R., Ishidate, F., Chadda, R., Miwa, Y., Naruse, K., Shirai, Y.M., Fujiwara, T.K., and Kusumi, A. (2013). Rac1 recruitment to the archipelago structure of the focal adhesion through the fluid membrane as revealed by single-molecule analysis. Cytoskeleton 70, 161-177.
  9. Suzuki, K.G., Kasai, R.S., Hirosawa, K.M., Nemoto, Y.L., Ishibashi, M., Miwa, Y., Fujiwara, T.K., and Kusumi, A. (2012). Transient GPI-anchored protein homodimers are units for raft organization and function. Nat. Chem. Biol. 8, 774-783.
  10. Shibata, A.C., Fujiwara, T.K., Chen, L., Suzuki, K.G., Ishikawa, Y., Nemoto, Y.L., Miwa, Y., Kalay, Z., Chadda, R., Naruse, K., and Kusumi, A. (2012). Archipelago architecture of the focal adhesion: membrane molecules freely enter and exit from the focal adhesion zone. Cytoskeleton 69, 380-392.
  11. Sheng, R., Chen, Y., Yung Gee, H., Stec, E., Melowic, H.R., Blatner, N.R., Tun, M.P., Kim, Y., Kallberg, M., Fujiwara, T.K., Hong, J.H., Kim, K.P., Lu, H., Kusumi, A., Lee, M.G., and Cho, W. (2012). Cholesterol modulates cell signaling and protein networking by specifically interacting with PDZ domain-containing scaffold proteins. Nat. Commun. 3, 1249.
  12. Kalay, Z., Fujiwara, T.K., and Kusumi, A. (2012). Confining domains lead to reaction bursts: reaction kinetics in the plasma membrane. PLoS One 7, e32948.
  13. Kasai, R.S., Suzuki, K.G., Prossnitz, E.R., Koyama-Honda, I., Nakada, C., Fujiwara, T.K., and Kusumi, A. (2011). Full characterization of GPCR monomer-dimer dynamic equilibrium by single molecule imaging. J. Cell Biol. 192, 463-480.
  14. Tanaka, K.A., Suzuki, K.G., Shirai, Y.M., Shibutani, S.T., Miyahara, M.S., Tsuboi, H., Yahara, M., Yoshimura, A., Mayor, S., Fujiwara, T.K., and Kusumi, A. (2010). Membrane molecules mobile even after chemical fixation. Nat. Methods 7, 865-866.
  15. Umemura, Y.M., Vrljic, M., Nishimura, S.Y., Fujiwara, T.K., Suzuki, K.G., and Kusumi, A. (2008). Both MHC class II and its GPI-anchored form undergo hop diffusion as observed by single-molecule tracking. Biophys. J. 95, 435-450.

A01: 原田 彰宏(大阪大学大学院医学系研究科)

  1. Nur, A., Kunii, M., Avriyanti,E., Furumoto, N., Inami, K., Yoshimura, S., Harada, R.,,and Harada, A. (2014). The Role of PKD in Cell Polarity, Biosynthetic Pathways, and Organelle/F-actin Distribution Cell Struct. Funct.39:61-77, http://dx.doi.org/10.1247/csf.13020
  2. Sato, T., Iwano, T., Kunii, M., Matsuda, S., Mizuguchi, R., Jung, Y., Hagiwara, H., Yoshihara, Y., Yuzaki, M., Harada, R., and Harada, A. (2014). Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis. J Cell Sci.127:422-431. doi: 10.1242/jcs.136903.
  3. D’Angelo, G., Uemura, T., Chuang, C., Polishchuk, E., Santoro, M., Ohvo-Rekila, H., Sato, T., Di Tullio, G., Varriale, A., D’Auria, S., Daniele, T., Capuani, F., Johannes, L., Mattjus, P., Monti, M., Pucci, Pl., Williams,,R.L., Burke, J.E., Platt, F.M., Harada, A., and De Matteis M.A. (2013) Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi. Nature 501,116-120, doi:10.1038/nature12423
  4. Takasuga S, Horie Y, Sasaki J, Sun-Wada GH, Kawamura N, Iizuka R, Mizuno K, Eguchi S, Kofuji S, Kimura H, Yamazaki M, Horie C, Odanaga E, Sato Y, Chida S, Kontani K, Harada A, Katada T, Suzuki A, Wada Y, Ohnishi H, Sasaki T. (2013). Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc Natl Acad Sci U S A. 110:1726-1731.
  5. Hashimoto Y, Muramatsu K, Kunii M, Yoshimura S, Yamada M, Sato T, Ishida Y, Harada R, Harada A. (2012). Uncovering genes required for neuronal morphology by morphology-based gene trap screening with a revertible retrovirus vector. FASEB J 26: 4662-4674.
  6. Sato M, Yoshimura S, Hirai R, Goto A, Kunii M, Atik N, Sato T, Sato K, Harada R, Shimada J, Hatabu T, Yorifuji H, Harada A. (2011). The role of VAMP7/TI-VAMP in cell polarity and lysosomal exocytosis in vivo. Traffic, 12: 1383-1393.
  7. Sato M, Saegusa K, Sato K, Hara T, Harada A, Sato K. (2011). Caenorhabditis elegans SNAP-29 is required for organellar integrity of the endomembrane system and general exocytosis in intestinal epithelial cells. Mol Biol Cell 22: 2579-2587.
  8. Uemura T, Sato T, Aoki T, Yamamoto A, Okada T, Hirai R, Harada R, Mori K, Tagaya M, Harada A. (2009). p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival. Mol Cell Biol 29: 1869-1881.
  9. Sato M, Grant BD, Harada A, Sato K. (2008). Rab11 is required for synchronous secretion of chondroitin proteoglycans after fertilization in Caenorhabditis elegans. J Cell Sci 121: 3177-3186.
  10. Sato M, Sato K, Liou W, Pant S, Harada A, Grant BD. (2008). Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein. EMBO J 27: 1183-1196.
  11. Sato T, Mushiake S, Kato Y, Sato K, Sato M, Takeda N, Ozono K, Miki K, Kubo Y, Tsuji A, Harada R, Harada A. (2007). The Rab8 GTPase regulates apical protein localization in intestinal cells. Nature 448: 366-369.

A01: 松浦 伸也(広島大学 原爆放射線医科学研究所)

  1. The microtubule depolymerizing activity of a mitotic kinesin protein KIF2A drives primary cilia disassembly coupled with cell proliferation. Miyamoto T, Hosoba K, Ochiai H, Royba E, Izumi H, Sakuma T, Yamamoto T, Dynlacht BD, Matsuura S. Cell Rep (in press)
  2. TALEN-mediated single-base editing identification of an intergenic mutation upstream of BUB1B as causative of PCS (MVA) syndrome. Ochiai H, Miyamoto T, Hosoba K, Sakuma T, Kudo Y, Asami K, Ogawa A, Watanabe A, Kajii T, Yamamoto T, Matsuura S. Proc Natl Acad Sci USA 111, 1461-1466 (2014)
  3. Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity. Sakuma T, Ochiai H, Kaneko T, Mashimo T, Tokumasu D, Sakane Y, Suzuki K, Miyamoto T, Sakamoto N, Matsuura S, Yamamoto T. Sci Rep 337, 219-223 (2013)
  4. Efficient TALEN construction and evaluation methods for human cell and animal applications. Sakuma T, Hosoi S, Woltjen K, Suzuki K, Kashiwagi K, Wada H, Ochiai H, Miyamoto T, Kawai N, Sasakura Y, Matsuura S, Okada Y, Kawahara A, Hayashi S, Yamamoto T. Genes Cells. 18: 315-26, (2013)
  5. Zinc-finger nuclease-mediated targeted insertion of reporter genes for quantitative imaging of gene expression in sea urchin embryos. Ochiai H, Sakamoto N, Nishikawa M, Suzuki K, Matsuura S, Miyamoto T, Sakuma T, Shibata T, Yamamoto T. Proc Natl Acad Sci USA, 109: 10915-10920, (2012)
  6. Nucleolin participates in DNA double-strand break-induced damage response through MDC1-dependent pathway. Kobayashi J, Fujimoto H, Sato J, Hayashi I, Burma S, Matsuura S, Chen DJ, Komatsu K. PLoS One, 7(11) e49245, (2012)
  7. Miyamoto T, Porazinski S, Wang H, Boravina A, Ciruna B, Shimizu A, Kajii T, Kikuchi A, Furutani-Seiki M, Matsuura S. Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates. Hum Mol Genet 20, 2058-2070 (2011).
  8. Matsumoto Y, Miyamoto T, Sakamoto H, Izumi H, Nakazawa Y, Ogi T, Tahara H, Oku S, Hiramoto A, Shiiki T, Fujisawa Y, Ohashi H, Sakemi Y, Matsuura S. Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly. DNA Repair (Amst) 10, 314-321 (2011).
  9. Yanagihara H, Kobayashi J, Tateishi S, Kato A, Matsuura S, Tauchi H, Yamada K, Takezawa J, Sugasawa K, Masutani C, Hanaoka F, Weemaes CM, Mori T, Zou L, Komatsu K. NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis. Mol Cell 43: 788-789 (2011)
  10. Kobayashi J, Okui M, Asaithamby A, Burma S, Chen BP, Tanimoto K, Matsuura S, Komatsu K, Chen DJ. WRN participates in translesion synthesis pathway through interaction with NBS1. Mech Ageing Dev 131, 436-444 (2010).
  11. Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y, Kinoshita Y, Kamada M, Nodera H, Suzuki H, Komure O, Matsuura S, Kobatake K, Morimoto N, Abe K, Suzuki N, Aoki M, Kawata A, Hirai T, Kato T, Ogasawara K, Hirano A, Takumi T, Kusaka H, Hagiwara K, Kaji R, Kawakami H. Mutations of optineurin in amyotrophic lateral sclerosis. Nature 465, 223-226 (2010).
  12. Fujita K, Takechi E, Sakamoto N, Sumiyoshi N, Izumi S, Miyamoto T, Matsuura S, Tsurugaya T, Akasaka K, Yamamoto T. HpSulf, a heparan sulfate 6-O-endosulfatase, is involved in the regulation of VEGF signaling during sea urchin development. Mech Dev 127, 235-245 (2010).
  13. Kanemoto N, Fukushima T, Imoto N, Koike K, Kanemoto K, Matsuura S. Sporadic neonatal Fanconi's anemia with VACTERL association. Pediatr Int 52,141-142 (2010).

A01: 政池 知子(東京理科大学理工学部)

  1. Kikuchi, Y., Naka,Y., Osakabe, H., Okamoto, T., Masaike, T., Ueno, H., Toyabe, S., Muneyuki, E. (2014). Thermodynamic analyses of nucleotide binding to an isolated monomeric beta subunit and the alpha3beta3gamma subcomplex of F1-ATPase. Biophys. J. 105 : 2541-2548.
  2. Masaike, T. Imaging Motions, Functions,and Reactions of Single Molecules. (2014). Invited Talk, OIST workshop Single Protein Dynamics in Cellulo 2014: Spatio-Temporal, Structural and Quantitative Analyses.
  3. Kinosita, Y., Nakane, D., Sugawa, M., Masaike, T., Mizutani, K., Miyata, M., Nishizaka, T. (2014). Unitary step of gliding machinery in Mycoplasma mobile. Proc. Natl. Acad. Sci. USA. 111: 23, 8601-8606.
  4. Masaike, T., Ikegami, K., Setou, M., Nishizaka, T. (2013). Invited talk, Motions in Ciliary Axonemes that Cause Functions. the 25th CDB meeting, RIKEN, Japan
  5. Masaike, T. Ikegami, K., Nakayama, R., Setou, M., Nishizaka, T. (2012). Motions in F1-ATPase and ciliary axonemes that drive Functions. Oral presentation, The 50th Annual Meeting of the Biophysical Society of Japan.
  6. Sugawa, M., Okada, K. A., Masaike, T., Nishizaka, T. (2011). A change in the radius of rotation of F1-ATPase indicates a tilting motion of the central shaft. Biophys. J. 101 : 2201-2206.
  7. Nishizaka, T., Hashimoto, Y., Masaike, T. (2011). Simultaneous observation of chemomechanical coupling of a molecular motor. Meth. Mol. Biol. Single Molecule Enzymology: Methods and Protocols 778 : 259-271
  8. Masaike, T., Koyama-Horibe, F., Oiwa, K., Yoshida, M., Nishizaka, T. (2008). Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80° and 40° substep rotations. Nat. Struct. Mol. Biol. 15 : 1326-33
  9. Masaike, T., Suzuki, T., Tsunoda, S. P., Konno, H., Yoshida, M. (2006). Probing conformations of the β subunit of FoF1-ATP synthase in catalysis. Biochem. Biophys. Res. Commun. 342 : 800-807
  10. Yasuda, R., Masaike, T., Adachi, K., Noji, H., Itoh, H., Kinosita, K. Jr. (2003). The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer. Proc. Natl. Acad. Sci. USA 100 : 9314-9318
  11. Masaike. T., Muneyuki, E., Noji, H., Kinosita, K. Jr., Yoshida, M. (2002). F1-ATPase changes its conformations upon phosphate release. J. Biol. Chem. 277 : 21643-21649

A02: 若林 憲一(東京工業大学 資源化学研究所)

  1. Owa M, Furuta A, Usukura J, Arisaka F, King SM, Witman GB, Kamiya R, and Wakabayashi K. (2014) Cooperative binding of the outer arm docking complex underlies the regular arrangement of outer arm dynein in the axoneme Proc Natl Acad Sci U S A. 111:9461-6.
  2. 荒井 祐介, 若林 憲一, 吉川 雅英, 奥 寛雅, 石川 正俊 (2013) 暗視野顕微鏡法におけるクラミドモナスの三次元トラッキング 日本ロボット学会誌 31:1028-1035
  3. Ide, T., Owa, M., King, S.M., Kamiya, R., Wakabayashi, K. (2013). Protein-Protein Interactions between Intermediate Chains and the Docking Complex of Chlamydomonas Flagellar Outer Arm Dynein. FEBS Lett. 587:2143-9.
  4. Engel, B.D., Ishikawa, H., Wemmer, K.A., Geimer, S., Wakabayashi, K., Hirono, M., Craige, B., Pazour, G.J., Witman, G.B., Kamiya, R., and Marshall, W.F. (2012). The role of retrograde intraflagellar transport in flagellar assembly and function. J Cell Biol. 199:151-167.
  5. Mochiji, S., Wakabayashi, K. (2012). Redox regulation of phototactic migration in the green alga Chlamydomonas reinhardtii and its possible application. Commun Integr Biol. 5:196-8.
  6. VanderWaal, K.E., Yamamoto, R., Wakabayashi, K., Fox, L., Kamiya, R., Dutcher, S.K., Bayly, P., Sale, W.S., and Porter, M.E. (2011). bop5 mutations reveal new roles for the IC138 phosphoprotein in the regulation of flagellar behavior. Mol Biol Cell. 22:2862-74.
  7. Wakabayashi, K., Misawa, Y., Mochiji, S., and Kamiya, R. (2011). Reduction-oxidation poise regulates the sign of phototaxis in Chlamydomonas reinhardtii. Proc Natl Acad Sci U S A. 108:11280-4.
  8. Kohno, T., Wakabayashi, K., Diener, D.R., Rosenbaum, J.L., and Kamiya, R. (2011). Subunit interactions within the Chlamydomonas flagellar spokehead. Cytoskeleton (Hoboken) 68:237-46.
  9. Kawai, T., Abe, H., Wakabayashi, K., and Oka, Y. (2009). Calcium oscillations in the olfactory non-sensory cells of the goldfish, Carassius auratus. Biochim Biophys Acta. 1790:1681-8.
  10. Wakabayashi, K. (2009). Analysis of redox-sensitive dynein components. Methods Cell Biol. 92 “Cilia: Motors and Regulation”, Academic Press, pp.153-161.
  11. Wakabayashi, K., Ide, T., and Kamiya, R. (2009). Calcium-dependent flagellar motility activation in Chlamydomonas reinhardtii in response to mechanical agitation. Cell Motil Cytoskeleton 66:736-42.

A02: 池上 浩司(浜松医科大学)

  1. Hayasaka T, Goto-Inoue N, Masaki N, Ikegami K, Setou M. Application of 2,5-dihydroxyacetophenone with sublimation provides more efficientionization of lipid species by atmospheric-pressure matrix-assisted laser desorption/ionization imaging mass spectrometry. Surf Interface Anal. 46(12-13):1219-1222, 2014.
  2. Cytosolic carboxypeptidase 5 removes α- and γ-linked glutamates from tubulin. Berezniuk I, Lyons PJ, Sironi JJ, Xiao H, Setou M, Angeletti RH, Ikegami K, Fricker LD. J Biol Chem. 288(42):30445-30453, 2013.
  3. Konno A, Setou M, Ikegami K. Ciliary and flagellar structure and function--their regulations by posttranslational modifications of axonemal tubulin. Int Rev Cell Mol Biol. 294:133-171, 2012.
  4. Lee JE, et al. CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium. Nat Genet. 44(2):193-199, 2012.
  5. Berezniuk I, Vu HT, Lyons PJ, Sironi JJ, Xiao H, Burd B, Setou M, Angeletti RH, Ikegami K, Fricker LD. Cytosolic carboxypeptidase 1 is involved in processing α- and β-tubulin. J Biol Chem. 287(9):6503-6517, 2012.
  6. Ikegami K, Sato S, Nakamura K, Ostrowski LE, Setou M. Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry. Proc Natl Acad Sci USA. 107(23):10490-10495, 2010.
  7. Ikegami K, Setou M. Unique post-translational modifications in specialized microtubule architecture. Cell Struct Funct. 35(1):15-22, 2010.
  8. Ikegami K, Setou M. TTLL10 can perform tubulin glycylation when co-expressed with TTLL8. FEBS Lett. 583(12):1957-1963, 2009.

A02: 花房 洋(名古屋大学大学院理学研究科)

  1. Kedashiro, S., Pastuhov, S., Nishioka, T., Watanabe, T., Kaibuchi, K., Matsumoto, K. and Hanafusa, H. LRRK1-phosphorylated CLIP-170 regulates EGFR trafficking by recruiting p150Glued to microtubule plus-ends. J. Cell Sci. in press
  2. Ishikawa, K., Nara, A., Matsumoto, K., and Hanafusa, H. (2012).EGFR-dependent phosphorylation of Leucine-rich repeat kinase LRRK1 is important for proper endosomal trafficking of EGFR. Mol. Biol. Cell 23:1294-1306.
  3. Hanafusa, H., Ishikawa, K., Kedashiro, S., et al. (2011). Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor. Nature Commun. 2:158.
  4. Hanafusa, H., Matsumoto, K., and Nishida, E. (2009). Regulation of the ERK activity duration by Sprouty contributes to dorsoventral patterning. Nature Cell Biology 11:106-109.

A02: 西田 宏記(大阪大学大学院理学研究科)

  1. Kuwajima, M., Kumano, G., and Nishida, H. (2014). Regulation of the number of cell division rounds by tissue-specific transcription factors and Cdk inhibitor during ascidian embryogenesis. PLOS ONE 9, e90188. doi:10.1371/journal.pone.0090188.
  2. Kumano, G., Negoro, N., and Nishida, H. (2014). Transcription factor Tbx6 plays a central role in fate determination between mesenchyme and muscle in embryos of the ascidian, Halocynthia roretzi. Dev. Growth Differ. 56, 310-322.
  3. Yamada, A., and Nishida, H. (2014). Control of the number of cell division rounds in distinct tissues during ascidian embryogenesis. Dev. Growth Differ. 56, 376–386.
  4. Nishida, H and Stach, T. (2014). Cell lineages and fate maps in tunicates: Conservation and modification. Zool. Sci. 31, 645-652.
  5. Kishi, K., Onuma, T. A., and Nishida, H. (2014). Long-distance cell migration during larval development in the appendicularian, Oikopleura dioica. Dev. Biol. 395, 299-306.
  6. Stolfi, A., Sasakura, Y., Chalopin, D., Satou, Y., Christiaen, L., Dantec, C., Endo, T., Naville, M., Nishida, H., Swalla, B., Volff J-N, Voskoboynik, A., Dauga, D., and Lemaire, P. (2014). Guidelines for the nomenclature of genetic elements in tunicate genomes. Genesis in press.
  7. Omotezako, T., Nishino, A., Onuma T. A. and Nishida, H. (2013). RNA interference in the appendicularian Oikopleura dioica reveals the function of the Brachyury gene. Dev. Genes Evol. 223, 261-267.
  8. Nishida, H. (2012). The maternal muscle determinant in the ascidian egg. WIREs Dev. Biol. 1, 425-433. doi: 10.1002/wdev.22.
  9. Makabe, K. and Nishida, H. (2012). Cytoplasmic localization and reorganization in ascidian eggs: Role of postplasmic/PEM RNAs in axis formation and fate determination. WIREs Dev. Biol. 1, 501-518. doi: 10.1002/wdev.54.
  10. Nishide, K., Mugitani, M., Kumano, G. and Nishida, H. (2012). Neurula rotation determines left-right asymmetry in ascidian tadpole larvae. Development 139, 1467-1475.
  11. Ouchi, K., Nishino, A. and Nishida, H. (2011). Simple procedure for sperm cryopreservation in the larvacean tunicate Oikopleura dioica. Zool. Sci. 28, 8-11.
  12. Negishi, T., Kumano, G. and Nishida, H. (2011). Polo-like kinase 1 is required for localization of PEM protein to the centrosome-attracting body and unequal cleavages in ascidian embryos. Dev. Growth Differ. 53, 76-87.
  13. Hashimoto, H., Enomoto, T., Kumano, G. and Nishida, H. (2011). The transcription factor FoxB mediates temporal loss of cellular competence for notochord induction in ascidian embryos. Development 138, 2591-2600.
  14. Fujikawa, T., Takatori, N., Kuwajima,M., Kim G. J. and Nishida, H. (2011). Tissue-specific regulation of the number of cell division rounds by inductive cell interaction and transcription factors during ascidian embryogenesis. Dev. Biol. 355, 313-323.
  15. Kumano, G., Takatori, N., Negishi, T., Takada T. and Nishida, H. (2011). A maternal factor unique to ascidians silences the germline via binding to P-TEFb and RNAP II regulation. Curr. Biol. 21, 1308-1313.
  16. Nishida, H., Satoh, N. and Hirose, E. (2010). More diversity and more convergence in tunicate biology. Zool. Sci. 27, 67-68.
  17. Kobayashi, M., Takatori, N., Nakajima, Y., Kumano, G., Nishida, H. and Saiga, H. (2010). Spatial and temporal expression of two transcriptional isoforms of Lhx3, a LIM class homeobox gene, during embryogenesis of two phylogenetically remote ascidians, Halocynthia roretzi and Ciona intestinalis. Gene Expression Patterns 10, 98-104.
  18. Prodon, F., Chenevert, J., Hebras, C., Dumollard, R., Faure, E., Gonzalez-Garcia, J., Nishida, H., Sardet, C. and McDougall, A. (2010). Dual mechanism controls asymmetric spindle position in ascidian germ cell precursors. Development 137, 2011-2021.
  19. Kumano, G., Kawai, N. and Nishida, H. (2010). Macho-1 regulates unequal cell divisions independently of its function as a muscle determinant. Dev. Biol. 344, 284-292.
  20. Takatori, N., Kumano, G., Saiga, H. and Nishida, H. (2010). Segregation of germ layer fates by nuclear migration-dependent localization of Not mRNA. Dev. Cell 19, 589-598.
  21. Denoeud, F., Henriet, S., ……, Nishida, H., (34番目)……… Wincker, P. and Chourrout, D. (計51人). (2010). Plasticity of animal genome architecture unmasked by rapid evolution of a pelagic tunicate. Science 330, 1381-1385.
  22. Prodon, F., Hanawa, K. and Nishida, H. (2009). Actin microfilaments guide the polarized transport of nuclear pore complexes and the cytoplasmic dispersal of Vasa mRNA during GVBD in the ascidian Halocynthia roretzi. Dev. Biol. 330, 377-388.
  23. Kumano, G. and Nishida, H. (2009). Patterning of an ascidian embryo along the anterior-posterior axis through spatial regulation of competence and induction ability by maternally localized PEM. Dev. Biol. 331, 78-88.
  24. Niwano, T., Takatori, N. Kumano, G., and Nishida, H. (2009). Wnt5 is required for notochord cell intercalation in the ascidian Halocynthia roretzi. Biol. Cell 101, 645-659.
  25. Prodon, F., Sardet, C. and Nishida, H. (2008). Cortical and cytoplasmic flows driven by actin microfilaments polarize the cortical ER-mRNA domain along the a-v axis in ascidian oocytes. Dev. Biol. 313, 682-699.
  26. Fujii, S., Nishio, T. and Nishida, H. (2008). Cleavage pattern, gastrulation, and neurulation in the appendicularian, Oikopleura dioica. Dev. Genes Evol. 218, 69-79.
  27. Sardet, C., Swalla, B. J., Satoh, N., Sasakura, Y., Branno, M., Thompson, E. M., Levine, M. and Nishida, H. (2008). Meeting review. Euro chordates: Ascidian community swims ahead. Dev. Dynam. 237, 1207-1213.
  28. Nishida, H. (2008). Development of the appendicularian Oikopleura dioica: culture, genome, and cell lineages. Dev. Growth Differ. 50, S239-S256.
  29. Lemaire, P., Smith, W. C. and Nishida, H. (2008). Ascidians and the plasticity of the chordate developmental program. Curr. Biol. 18, R620-R631.

A02: 大森 義裕(大阪大学 蛋白質研究所)

  1. Chaya T, Omori Y, Kuwahara R, Furukawa T, (2014) ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport. EMBO J 33(11):1227-1242.
  2. Omori Y, Araki1 F, Chaya T, Kajimura N, Irie S, Terada K, Muranishi Y, Tsujii T, Ueno S, Koyasu T, Tamaki Y, Kondo M, Amano S, Furukawa T. (2012). Presynaptic dystroglycan-pikachurin complex regulates the proper synaptic connection between retinal photoreceptor and bipolar cells. J Neurosci 32(18):6126-6137.
  3. Zhao C, Omori Y, Brodowska K, Kovach P, Malicki J. (2012). Kinesin-2 family in vertebrate ciliogenesis. Proc Natl Acad Sci U S A. 109(7):2388-93.
  4. Omori Y, Katoh K, Sato S, Muranishi Y, Chaya T, Onishi A, Minami T, Fujikado T, Furukawa T. (2011). Analysis of transcriptional regulatory pathways of photoreceptor genes by expression profiling of the Otx2-deficient retina. PLoS One 6(5):e19685.
  5. Omori Y, Chaya T, Katoh K, Kajimura N, Sato S, Muraoka K, Ueno S, Koyasu T, Kondo M, Furukawa T. (2010). Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival. Proc Natl Acad Sci U S A. 107(52):22671-6.
  6. Kanagawa M, Omori Y, Sato S, Kobayashi K, Miyagoe-Suzuki Y, Takeda S, Endo T, Furukawa T, Toda T. (2010). Post-translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localization. J Biol Chem. 285(41):31208-16.
  7. Katoh K, Omori Y, Onishi A, Sato S, Kondo M, Furukawa T. (2010). Blimp1 suppresses Chx10 expression in differentiating retinal photoreceptor precursors to ensure proper photoreceptor development. J Neurosci 30 (19) 6515-6526.
  8. Sanuki R, Omori Y, Koike C, Sato S, Furukawa T. (2010). Panky, a novel photoreceptor-specific ankyrin repeat protein, is a transcriptional cofactor that suppresses CRX-regulated photoreceptor genes. FEBS letter 584 (4):753-8.
  9. Sato S, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata M, Funabiki K,Koyasu T, Kajimura N, Miyoshi T, Sawai H, Kobayashi K, Tani A, Toda T, Usukura J, Tano Y, Fujikado T and Furukawa T. (2008). Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation. Nature Neuroscience 11(8)923-931.
  10. Omori Y, Zhao C, Saras A, Mukhopadhyay S, Kim W, Furukawa T, Sengupta P, Veraksa A, Malicki J. (2008). Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8. Nature Cell Biology. 10(4):437-44.
  11. Blachon S, Gopalakrishnan J, Omori Y, Polyanovsky A, Church A, Nicastro D, Malicki J, Avidor-Reiss T. (2008). Drosophila asterless and vertebrate Cep152 Are orthologs essential for centriole duplication. Genetics. 180(4):2081-94.
  12. Tsujikawa M, Omori Y, Biyanwila J, Malicki J. (2007). Mechanism of positioning the cell nucleus in vertebrate photoreceptors. Proc Natl Acad Sci U S A. 104(37):14819-14824.

A02: 斎藤 祐見子(広島大学大学院総合科学研究科)

  1. Hamamoto A, Kobayashi Y, *Saito Y. (2015) Identification of amino acids that are selectively involved in Gi/o activation by the rat melanin-concentrating hormone receptor 1. Cellular Signaling, in press
  2. Nagasaki H, *Saito Y. Melanin-concentrating hormone (MCH) in Handbook of Hormone, Eds. Takei Y and Takahashi A, Elsevier, in press
  3. Nagasaki H, *Saito Y. Cocaine and Amphetamine Regulated Transcript (CART) in Handbook of Hormone, Eds. Takei Y and Takahashi A, Elsevier, in press
  4. Mizusawa K, Kawashima Y, Sunuma T, Hamamoto A, Kobayashi Y, Kodera Y, Saito Y, Takahashi A. Gen Comp Endocrinol. doi: 10.1016/j.ygcen.2014.07.008. in press
  5. Kobayashi, Y., Hamamoto, A., Hirayama, T., and *Saito Y. (2014) Molecular cloning, expression, and signaling pathway of four melanin-concentrating hormone receptors from Xenopus tropicalis. Gen Comp Endocrinol.doi: 10.1016/j.ygcen.2014.03.005. in press
  6. *Saito Y, Hamamoto A, Kobayashi Y. (2013) Regulated control of melanin-concentrating hormone receptor 1 through posttranslational modifications. Front Endocrinol (Lausanne). 4:154
  7. Nagata A, Hamamoto A, Horikawa M, Yoshimura K, Takeda S, *Saito Y. (2013) Characterization of ciliary targeting sequence of rat melanin-concentrating hormone receptor 1. Gen Comp Endocrinol. 188:159-165.
  8. Nagata A, Hamamoto A, Horikawa M, Yosimura K, Takeda S, Saito Y. (2013). Characterization of ciliary targeting sequence of rat melanin-concentrating hormone receptor 1. General Comp Endocri 188:159-165.
  9. Hamamoto A, Horikawa M, Saho T, Saito Y. (2012). Mutation of Phe318 within the NPxxY(x)5,6F motif in melanin-concentrating hormone receptor 1 results in an efficient signaling activity. Front. Endocrinology. 3:147. doi: 10.3389/fendo.2012.00147.
  10. Hamamoto A, Mizusawa K, Takahashi A, Saito Y. (2011). Signaling pathway of the goldfish melanin-concentrating hormone receptor 1 and 2. Regulatory Peptides. 169, 6-12.
  11. 斎藤祐見子 児島将康 (2011). 新規生理活性ペプチドの探索方法の進歩 実験医学増刊号「代謝・内分泌ネットワークと医薬応用」29, 80-85.
  12. Miyamoto-Matsubara M, and Saito Y. (2010). Functional interaction of regulator of G-protein-signaling-2 with melanin-concentrating hormone receptor 1. Ann NY Science. 1200, 112-119.
  13. Ukena K, Tachibana T, Iwakoshi-Ukena E, Saito Y, Minakata H, Kawaguchi R, Osugi T, Tobari Y, Leprince J, Vaudry H, Tsutsui K. (2010). Identification, localization, and function of a novel avian hypothalamic neuropeptide, 26RFa, and its cognate receptor, G Protein-Coupled Receptor-103. Endocrinology 151, 2255-2264.
  14. Chung S, Saito Y, Civelli O. (2009). MCH receptors/gene structure-in vivo expression. Peptides 30, 1985-1989.
  15. Aizaki Y, Nakano-Tetsuka M, Maruyama K, Saito Y. (2009). Distinct role of the DRY motif in rat melanin-concentrating hormone receptor 1 in signaling control. Peptides 30, 974-981.
  16. Nagasaki H, Chung S, Dooley CT, Wang Z, Li C, Saito Y, Clark SD, Houghten RA, Civelli O. (2009). The pharmacological properties of a novel MCH1 receptor antagonist isolated from combinatorial libraries. Eur J Pharmacol. 602, 194-202.
  17. Saito, Y and Nagasaki, H. (2008). The Melanin-Concentrating Hormone System and Its Physiological Functions "Results and Problems in Cell Differentiation: Orphan G protein-coupled receptors and novel neuropeptides" 46, 159-179, Eds. Civelli/Zhou, Springer Berlin / Heidelberg
  18. Miyamoto-Matsubara M, Saitoh O, Maruyama K, Aizaki Y, Saito Y. (2008). Regulation of melanin-concentrating hormone receptor 1 signaling by RGS8 with the receptor third intracellular loop. Cellular Signaling 20, 2084-2094.

A03: 大杉 美穂(東京大学大学院総合文化研究科)

  1. Soeda, S., Yamada, K., and Ohsugi, M. (2013). Inactivation of mitogen-activated protein kinase is neither necessary nor sufficient for the onset of pronuclear formation in mouse oocytes. Genes Cells. in press.
  2. Ozaki, Y., Matsui, H., Asou, H., Nagamachi, A., Aki, D., Honda, H., Yasunaga, S., Takihara, Y., Yamamoto, T., Izumi, S., Ohsugi, M., and Inaba, T. (2012). Poly-ADP Ribosylation of Miki by tankyrase-1 Promotes Centrosome Maturation. Mol Cell. 47, 694-706.
  3. Takahashi, A., Kikuguchi, C., Morita, M., Shimodaira, T., Tokai-Nishizumi, N., Yokoyama, K., Ohsugi, M., Suzuki, T., and Yamamoto, T. (2012). Involvement of CNOT3 in mitotic progression through inhibition of MAD1 expression. Biochem Biophys Res Commun. 419, 268-273
  4. Masuda, N., Shimodaira, T., Shiu, S.J., Tokai-Nishizumi, N., Yamamoto, T., and Ohsugi, M. (2011). Microtubule stabilization triggers the plus-end accumulation of Kif18A/kinesin-8. Cell Struct Funct. 2, 261-267.
  5. Kitajima, T.S., Ohsugi, M., and Ellenberg, J. (2011). Complete kinetochore tracking reveals error-prone homologous chromosome biorientation in Mammalian oocytes. Cell 146, 568-581.
  6. Oshimori, N., Li, X., Ohsugi, M., and Yamamoto, T. (2009). Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formation. EMBO J 28, 2066-2076.

A03: 貝淵 弘三(名古屋大学大学院医学系研究科)

  1. Matsui, T., Watanabe, T., Matsuzawa, K., Kakeno, M., Okumura, N., Sugiyama, I., Itoh, N., and Kaibuchi, K. (2014). PAR3 and aPKC regulate Golgi organization through CLASP2 phosphorylation to generate cell polarity. Mol Biol Cell, in press
  2. Hamaguchi, T., Nakamuta, S., Funahashi, Y., Takano, T., Nishioka, T., Hasanuzzaman, S.M., Yura, Y., Kaibuchi, K., and Amano, M. (2014). In vivo Screening for Substrates of Protein Kinase A using a combination of proteomic approaches and pharmacological modulation of kinase activity. Cell Struct Funct, in press
  3. Kakeno, M., Matsuzawa, K., Matsui, T., Akita, H., Sugiyama, I., Ishidate, F., Nakano, A., Takashima, S., Goto, H., Inagaki, M., et al. (2014). Plk1 phosphorylates CLIP-170 and regulates its binding to microtubules for chromosome alignment. Cell Struct Funct 39, 45-59.
  4. Funahashi, Y., Namba, T., Fujisue, S., Itoh, N., Nakamuta, S., Kato, K., Shimada, A., Xu, C., Shan, W., Nishioka, T., et al. (2013). ERK2-mediated phosphorylation of Par3 regulates neuronal polarization. J Neurosci 33, 13270-13285.
  5. Wang, S., Watanabe, T., Matsuzawa, K., Katsumi, A., Kakeno, M., Matsui, T., Ye, F., Sato, K., Murase, K., Sugiyama, I., Kimura, K., Mizoguchi, A., Ginsberg, M. H., Collard, J. G., and Kaibuchi, K. (2012). Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration. The Journal of cell biology 199, 331-345.
  6. Nishioka, T., Nakayama, M., Amano, M., and Kaibuchi, K. (2012). Proteomic screening for Rho-kinase substrates by combining kinase and phosphatase inhibitors with 14-3-3zeta affinity chromatography. Cell structure and function 37, 39-48.
  7. Kato, K., Yazawa, T., Taki, K., Mori, K., Wang, S., Nishioka, T., Hamaguchi, T., Itoh, T., Takenawa, T., Kataoka, C., Matsuura, Y., Amano, M., Murohara, T., and Kaibuchi, K. (2012). The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration. Molecular biology of the cell 23, 2593-2604.
  8. Sato, K., Watanabe, T., Wang, S., Kakeno, M., Matsuzawa, K., Matsui, T., Yokoi, K., Murase, K., Sugiyama, I., Ozawa, M., and Kaibuchi, K. (2011). Numb controls E-cadherin endocytosis through p120 catenin with aPKC. Molecular biology of the cell 22, 3103-3119.
  9. Namba, T., Nakamuta, S., Funahashi, Y., and Kaibuchi, K. (2011). The role of selective transport in neuronal polarization. Developmental neurobiology 71, 445-457.
  10. Nakamuta, S., Funahashi, Y., Namba, T., Arimura, N., Picciotto, M. R., Tokumitsu, H., Soderling, T. R., Sakakibara, A., Miyata, T., Kamiguchi, H., and Kaibuchi, K. (2011).Local application of neurotrophins specifies axons through inositol 1,4,5-trisphosphate, calcium, and Ca2+/calmodulin-dependent protein kinases. Science signaling 4, ra76.
  11. Amano, M., Tsumura, Y., Taki, K., Harada, H., Mori, K., Nishioka, T., Kato, K., Suzuki, T., Nishioka, Y., Iwamatsu, A., and Kaibuchi, K. (2010). A proteomic approach for comprehensively screening substrates of protein kinases such as Rho-kinase. PloS one 5, e8704.
  12. Arimura, N., Kimura, T., Nakamuta, S., Taya, S., Funahashi, Y., Hattori, A., Shimada, A., Menager, C., Kawabata, S., Fujii, K., Iwamatsu, A., Segal, R. A., Fukuda, M., and Kaibuchi, K. (2009). Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27. Dev Cell 16, 675-686.
  13. Nakayama, M., Goto, T. M., Sugimoto, M., Nishimura, T., Shinagawa, T., Ohno, S., Amano, M., and Kaibuchi, K. (2008). Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation. Dev Cell 14, 205-215.

A03: 松村 繁(京都大学 ウイルス研究所)

  1. Hamasaki, M., Matsumura, S., Satou, A., Takahashi, C., Oda, Y., Higashiura, C., Ishihama, Y., Toyoshima, F.(2014). Pregnenolone Functions in Centriole Cohesion during Mitosis. Chem Biol. 18, 1707-1721.
  2. Matsumura, S., Hamasaki, M., Yamamoto, T., Ebisuya, M., Sato, M., Nishida, E., and Toyoshima, F. (2012). ABL1 regulates spindle orientation in adherent cells and mammalian skin. Nat. Commun. 3: 626. doi:10.1038/ncomms1634.
  3. Matsumura, S., and Toyoshima, F. (2012). ABL1 joins the cadre of spindle orientation machinery. Cell Struct. Funct. 37, 81-87.
  4. Mitsushima, M., Aoki, K., Ebisuya, M., Matsumura, S., Yamamoto, T., Matsuda, M., Toyoshima, F., and Nishida, E. (2010). Revolving movement of a dynamic cluster of actin filaments during mitosis. J. Cell Biol. doi: 10.1083/jcb.201007136.

A03: 竹内 隆(鳥取大学医学部)

  1. Tane, S., Kubota, M., Okayama, H., Ikenishi, A., Yoshitome, S., Iwamoto, N., Satoh, Y., Kusakabe, A., Ogawa, S., Kanai, A., Molkentin, J. D., Nakamura, K., Ohbayashi, T., and Takeuchi, T. (2014) Repression of cyclin D1 expression is necessary for the maintenance of cell cycle exit in adult mammalian cardiomyocytes. J. Biol. Chem., 289, 18033-18044.
  2. Tane, S., Ikenishi, A., Okayama, H., Iwamoto, N., Nakayama, I. K., and Takeuchi, T. (2014) CDK inhibitors, p21Cip1 and p27Kip1, participate in cell cycle exit of mammalian cardiomyocytes. Biochem. Biophys. Res. Commun., 443, 1105-1109.
  3. Hayashi, T., Sakamoto, K., Sakuma, T., Yokotani, N., Inoue, T., Kawaguchi, E., Agata, K., Yamamoto, T., and Takeuchi, T. (2014) Transcription activator-like effector nucleases efficiently disrupt the target gene in Iberian ribbed newts (Pleurodeles waltl), an experimental model animal for regeneration. Dev. Growth Differ., 56, 115-121.
  4. Inagawa, M., Nakajima, K., Makino, T., Ogawa, S., Kojima, M., Ito, S., Ikenishi, A., Hayashi, T., Schwartz, R. J., Nakamura, K., Obayashi, T., Tachibana, M., Shinkai, Y., Maeda, K., Miyagawa-Tomita, S., and Takeuchi, T. (2013) Histone H3 Lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis. Mech. Dev. 130, 519-531.
  5. Hayashi, T., Yokotani, N., Tane, S., Matsumoto, A., Myouga, A., Okamoto, M., and Takeuchi, T. (2013) Molecular genetic system for regenerative studies using newts. Dev. Growth Differ.,55, 229-236.
  6. Ikenishi, A., Okayama, H., Iwamoto, N., Yoshitome, S., Tane, S., Nakamura, K., Obayashi, Ikenishi, A., Okayama, H., Iwamoto, N., Yoshitome, S., Tane, S., Nakamura, K., Obayashi, T., Hayashi, T., and Takeuchi, T. (2012) Cell cycle regulation in mouse heart during embryonic and postnatal stages. Dev. Growth. Differ., 54, 731-738.
  7. Takahashi, A., Imai, Y., Yamakoshi, K., Kuninaka, S., Ohtani, N., Yoshimoto, S., Hori, S., Tachibana, M., Anderton, E., Takeuchi, T., Shinkai, Y., Peters, G., Saya, H., and Hara, E. (2012) DNA damage signaling triggers degradation of histone methyltransferases through APC/CCdh1 in senescent cells. Mol. Cell, 45, 123-131.
  8. Nakajima, K., Inagawa, M., Uchida, C., Okada, K., Tane, S., Kojima, M., Kubota, M., Noda, M., Ogawa, S, Shirato, H., Sato, M., Suzuki-Migishima, R., Hino, T., Satoh, Y., Kitagawa, M., and Takeuchi, T. (2011) Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a Jumonji (Jarid2)-cyclin D1 pathway. Development, 138, 1771-1782.
  9. Kusunoki, H., Takeuchi, T., and Kohno, T. Solution structure of the AT-rich interaction domain of Jumonji/JARID2. (2009) Proteins, 76, 1023-1028
  10. Kaneko, S., Takeuchi, T., and *Itaya, M. Genetic connection of two contiguous Bacterial Artificial Chromosomes in the BGM vector. (2009) J. Biotech., 139, 211-213.
  11. Shirato, H., Ogawa, S., Nakajima, K., Inagawa, M., Kojima, M., Tachibana, M., Shinkai, Y., and Takeuchi, T. (2009) A Jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9. J. Biol. Chem., 284, 733-739.

A03: 廣田 ゆき(慶應義塾大学医学部)

  1. Hirota, Y., Kubo, K., Katayama, K., Honda, T., Fujino, T., Yamamoto, T., Nakajima, K. (2015) Reelin receptors ApoER2 and VLDLR are expressed in distinct spatio-temporal patterns in developing mouse cerebral cortex. J. Comp. Neurol. 523, 463-478.
  2. Ishii, K., Nagai, T., Hirota, Y., Noda, M., Nabeshima, T., Yamada, K., Kubo, K., Nakajima, K. (2015) Reelin has a preventive effect on phencyclidine-induced cognitive and sensory-motor gating deficits. Neurosci. Res. in press. (Ishii, K., Nagai, T., Hirota, Y. are co-first authors)
  3. Hirota, Y., Sawada, M., Kida, YS., Huang, SH., Yamada, O., Sakaguchi, M., Ogura, T., Okano, H., Sawamoto, K. (2012). Roles of planar cell polarity signaling in maturation of neuronal precursor cells in the postnatal mouse olfactory bulb. Stem Cells 30, 1726-33.
  4. Sawamoto, K., Hirota, Y., Alfaro-Cervello, C., Soriano-Navarro, M., He, X., Hayakawa-Yano, Y., Yamada, M., Hikishima, K., Tabata, H., Iwanami, A., Nakajima, K., Toyama, Y., Itoh, T., Alvarez-Buylla, A., Garcia-Verdugo, JM., and Okano, H. (2011). Cellular composition and organization of the subventricular zone and rostral migratory stream in the adult and neonatal common marmoset brain. J. Comp. Neurol. 519, 690-713.
  5. Hirota, Y., Meunier, A., Huang, S., Shimozawa, T., Yamada, O., Kida, Y.S., Inoue, M., Ito, T., Kato, H., Sakaguchi, M., Sunabori, T., Nakaya, M.A., Nonaka, S., Ogura, T., Higuchi, H., Okano, H., Spassky, N., and Sawamoto, K. (2010). Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin II. Development 137, 3037-3046.
  6. Ikeda, M., Hirota, Y., Sakaguchi, M., Yamada, O., Kida, Y.S., Ogura, T., Otsuka, T., Okano, H., Sawamoto, K. (2010). Expression and proliferation-promoting role of Diversin in the neuronally committed precursor cells migrating in the adult mouse brain. Stem Cells 28, 2017-26.
  7. Kojima, T., Hirota, Y., Ema, M., Takahashi, S., Miyoshi, I., Okano, H., and Sawamoto, K. (2010). Subventricular zone-derived neural progenitor cells migrate along a blood vessel scaffold toward the post-stroke striatum. Stem Cells 28, 545-554.
  8. Guirao, B., Meunier, A., Mortaud, S., Aguilar, A., Corsi, J.M., Strehl, L., Hirota, Y., Desoeuvre, A., Boutin, C., Han, Y.G., Mirzadeh, Z., Cremer, H., Montcouquiol, M., Sawamoto, K., and Spassky, N. (2010). Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile cilia. Nat. Cell Biol. 12, 341-350.