文部科学省科学研究費補助金「新学術領域研究」 シリア・中心体系による生体情報フローの制御

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計画班|公募班(平成27-28年度)公募班(平成25-26年度)

計画班

領域代表者: 濱田 博司(大阪大学大学院生命機能研究科)

  1. Shinohara, K., Kawasumi, A., Takamatsu, A., Yoshiba, S., Botilde, Y., Motoyama, N., Reith, W., Durand, B., Shiratori, H. and Hamada, H. (2012). Two rotating cilia in the node cavity are sufficient to break left-right symmetry in the mouse embryo. Nature Commun. 3 : 622doi: 10.1038/ncomms1624.
  2. Nakamura, T., Saito, D., Kawasumi, A., Shinohara, K., Asai, Y., Takaoka, K., Dong, F., Takamatsu, A., Belo, J.A., Mochizuki, A., and Hamada, H. (2012).Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA in the mouse embryo. Nat. Communic. 3:1322.doi:10.1038/ncomms 2319.
  3. Lei, Z., Tamura, A., Maeda, T., Yamazaki, Y., Nakamura, T., Shiratori, H., Yashiro, K., Tsukita, S, and Hamada, H. (2012). EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins. Dev. Biol. 371:136-45.
  4. Yoshiba, S., Shiratori, H., Kawasumi, A., Shinohara, K., Sasaki, G., Belo, J.A., Nonaka, S., Sasaki, H., Kuo, I., Ehrlich, B., Pennekamp, P., Dworniczak, B., and Hamada, H. (2012). Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2. Science, 338:226-231.
  5. Nakamura, T. and Hamada, H. (2012). Lefty-right asymmetry: conserved or diverged. Development. 139:3257-3262.
  6. Takaoka, K., Yamamoto, M. and Hamada, H. (2011). Origin and role of distal visceral endoderm, a group of cells that determines anterior-posterior polarity of the mouse embryo. Nat. Cell Biol. 13(7),743-752.
  7. Ajima, R. and Hamada, H. (2011). Wnt signaling escapes to cilia. Nat. Cell Biol. (News and Views), 13, 636-637.
  8. Kawasumi, A., Nakamura, T., Iwai, N., Yashiro, K., Saijoh, Y., Belo, J.A., Shiratori, H. and Hamada, H. (2011). Left-right asymmetry in the level of active Nodal protein produced in the node is translated into the asymmetry in the lateral plate of mouse embryo. Dev Biol. 353, 321-330.
  9. Hashimoto, M., Shinohara, K., Wang, J., Ikeuchi, S., Meno, C., Yoshiba, S., Takada S., Hatta, K., Wynshaw-Boris, T., and Hamada, H. (2010). Planar polarization of the node cells determines the rotation axis of the node cilia. Nat. Cell Biol. 12, 170-176.
  10. Oki, S., Kitajima, K., Belo, J.A., Yokoyama, T., Hamada, H. and Meno, C. (2009). Reversal of left-right asymmetry by aberrant Nodal signaling in the node of mouse embryos. Development, 136, 3917-3925.
  11. Uehara, M., Yashiro, K., Takaoka, K., Yamamoto M., and Hamada, H. (2009). Removal of maternal retinoic acid by embryonic CYP26 for correct Nodal regulation during early embryonic patterning. Genes & Dev. 23, 1689-1698.
  12. Yamamoto M., Beppu, X., Takaoka, K., Meno, C., Li, E., Miyazono, K., and Hamada, H. (2009). Antagonism between Smad1 and Smad2 signaling regulates formation of the distal visceral endoderm in the mouse embryo. J. Cell Biol. 184, 323-334.
  13. Tanaka, C., Sakuma, R., Nakamura, T., Hamada, H., and Saijoh, Y. (2007). Long-range action of Nodal requires interaction with GDF1. Genes & Dev 21, 3272-3282.
  14. Yashiro, K., Shiratori, H., and Hamada, H. (2007). Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch. Nature, 450, 285-288.

A 01-1研究代表者: 月田 早智子(大阪大学大学院生命機能研究科)

  1. Wada, M., Tamura, A., Takahashi, N., and Tsukita, S. (2013). Loss of Claudins 2 and 15 From Mice Causes Defects in Paracellular Na(+) Flow and Nutrient Transport in Gut and Leads to Death from Malnutrition. Gastroenterology 144, 369-380.
  2. Hirata, T., Nomachi, A., Tohya, K., Miyasaka, M., Tsukita, S., Watanabe, T., and Narumiya, S. (2012) Moesin-deficient mice reveal a non-redundant role for moesin in lymphocyte homeostasis. Int. Immunol. 24, 705-717.
  3. Lei, Z., Maeda, T., Tamura, A., Nakamura, T., Yamazaki, Y., Shiratori, H., Yashiro, K., Tsukita, S., and Hamada, H. (2012). EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins. Dev. Biol. 371, 136-145.
  4. Tamura, A., Yamazaki, Y., Hayashi, D., Suzuki, K., Sentani, K., Yasui, W., and Tsukita, S. (2012). Claudin-based paracellular proton barrier in the stomach. Ann. NY Acad. Sci. 1258, 108-114.
  5. Itoh, M., Tsukita, S., Yamazaki, Y., and Sugimoto, H. Rho GTP exchange factor ARHGEF11 the integrity of epithelial junctions by connecting ZO-1 and RhoA-myosin II signaling. (2012). Proc. Natl. Acad. Sci. U.S.A. 109, 9905-9910.
  6. Kunimoto, K., Yamazaki, Y., Nishida, T., Shinohara, K., Ishikawa, H., Hasegawa, T., Okanoue, T., Hamada H., Noda, T., Tamura, A., Tsukita, S., and Tsukita, S. (2012). Coodinated ciliary beating regulates Odf2-mediated polarization of basal bodies via basal feet. Cell 148, 189-200.
  7. Yamazaki, Y., Tokumasu, R., Kimura, H., and Tsukita, S. (2011). Role of claudin species-specific dynamics in reconstitution and remodeling of the zonula occludens. Mol. Biol. Cell. 22, 1495-504.
  8. Yano, T., Yamazaki, Y., Adachi, M., Okawa, K., Fort, P., Uji, M., Tsukita, S., and Tsukita, S. Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling. (2011). J. Cell Biol. 193, 319-332.
  9. Tamura, A., Hayashi, H., Imasato, M., Yamazaki, Y., Hagiwara, A., Wada, M., Noda, T., Watanabe, M., Suzuki, Y., and Tsukita, S. (2011). Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption in mouse small intestine. Gastroenterology 140, 913-923.
  10. Strilic, B., Kucera, T., Eglinger, J., Hughes, M.R., McNagny, K.M., Tsukita, S., Dejana, E., Ferrara, N., and Lammert, E. (2009). The molecular basis of vascular lumen formation in the developing mouse aorta. Dev.Cell 17, 505-515.
  11. Yamazaki, Y., Umeda, K., Wada, M., Nada, S., Okada, M., Tsukita, S., and Tsukita, S. (2008). ZO-1-and ZO-2-dependent integration of myosin-2 to epithelial zonula adherens. Mol. Biol. Cell 19, 3801-3811.
  12. Nojima, H., Adachi, M., Matsui, T., Okawa, K., Tsukita, S., and Tsukita, S. (2008). IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade. Nat. Cell Biol. 10, 971-978.
  13. Tamura, A., Kitano, Y., Hata, M., Katsuno, T., Moriwaki, K., Sasaki, H, Hayashi, H., Suzuki, Y., Noda, T., Furuse, M., Tsukita, S., and Tsukita, S. (2008). Megaintestine in claudin-15-deficient mice. Gastroenterology 134, 523-534.
  14. Umeda,K., Ikenouchi,J., Katahira-Tayama,S., Furuse,K., Sasaki,H., Nakayama,M., Matsui,T., Tsukita, S, Furuse,M., and Tsukita,S. (2006). ZO-1 and ZO-2 determine independently determine where claudins are polymerized in tight-junction strand formation. Cell 126, 741-754.
  15. Ishikawa, H., Kubo, A., Tsukita, S., and Tsukita, S. (2005). Odf2-deficient mother centrioles lack distal/subdistal appendages and the ability to generate primary cilia. Nat. Cell Biol. 7, 517-524.

A 01-2研究代表者: 北川 大樹(国立遺伝学研究所)

  1. Shiratsuchi, G., Takaoka, K., Ashikawa, T., Hamada, H. and Kitagawa, D. (2014). RBM14 prevents assembly of centriolar protein complexes and maintains mitotic spindle integrity. EMBO J. DOI 10.15252/embj.201488979
  2. Ohta, M., Ashikawa, T., Nozaki, Y., Kozuka-Hata, H., Goto, H., Inagaki, M., Oyama, M. and Kitagawa, D. (2014). Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole. Nat. Commun., doi: 10.1038/ncomms6267.
  3. Kitagawa, D., Kohlmaier, G., Keller, D., Strnad, P., Balestra, F.R., Fluckiger, I. and Gonczy, P. (2011). Spindle positioning in human cells relies on proper centriole formation and on the microcephaly proteins CPAP and STIL. J. Cell Sci. 124, 3884-3893.
  4. Kitagawa, D., Vakonakis, I., Olieric, N., Hilbert, M., Keller, D., Olieric, V., Bortfeld, M., Erat, M.C., Fluckiger, I., Gonczy, P. and Steinmetz, M.O. (2011). Structural basis of the 9-fold symmetry of centrioles. Cell 144, 364-375.
  5. Kitagawa, D., Fluckiger, I., Polanowska, J., Keller, D., Reboul, J. and Gonczy, P. (2011). PP2A phosphatase acts upon SAS-5 to ensure centriole formation in C. elegans embryos. Dev. Cell 20, 550-562.
  6. Kitagawa, D., Busso, C., Fluckiger, I. and Gonczy, P. (2009). Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos. Dev. Cell 17, 900-907.
  7. Kitagawa, D., Kajiho, H., Negishi, T., Ura, S., Watanabe, T., Wada, T., Ichijo, H., Katada, T. and Nishina, H. (2006). Release of RASSF1C from the nucleus by DAXX degradation links DNA damage and SAPK/JNK activation. EMBO J. 25, 3286-3297.

A 02-2研究代表者: 稲垣 昌樹(愛知県がんセンター研究所)

  1. Kasahara, K., Goto, H., Izawa, I., Kiyono, T., Watanabe, N., Elowe, S., Nigg, E.A. and Inagaki, M. (2013). PI 3-kinase-dependent phosphorylation of Plk1-Ser99 promotes its association with 14-3-3γ and is required for metaphase-anaphase transition. Nat. Commun. in press.
  2. Goto, H., Inoko, A. and Inagaki, M. (2013). Cell cycle progression by the repression of primary cilia formation in proliferating cells. Cell. Mol. Life Sci. in press.
  3. Inoko, A., Matsuyama, M., Goto, H., Ohmuro-Matsuyama, Y., Hayashi, Y., Enomoto, M., Ibi, M., Izawa, I., Urano, T., Yonemura, S., Kiyono, T. and Inagaki, M. (2012). Trichoplein blocks aberrant primary cilia assembly in proliferating cells. J. Cell Biol. 197, 391-405.
  4. Ibi, M., Zou, P., Inoko, A., Shiromizu, T., Matsuyama, M., Hayashi, Y., Enomoto, M., Mori, D., Hirotsune, S., Kiyono, T., Tsukita, S., Goto, H. and Inagaki, M. (2011). Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein. J. Cell Sci. 124, 857-864.
  5. Matsuyama, M., Goto, H., Kasahara, K., Kawakami, Y., Nakanishi, M., Kiyono, T., Goshima, N. and Inagaki, M. (2011). Nuclear Chk1 prevents premature mitotic entry. J. Cell Sci. 124, 2113-2119.
  6. Helfand, B.T., Mendez, M.G., Murthy, S.N., Shumaker, D.K., Grin, B., Mahammad, S., Aebi, U., Wedig, T., Wu, Y.I., Hahn, K.M., Inagaki, M., Herrmann, H. and Goldman, R.D. (2011). Vimentin organization modulates the formation of lamellipodia. Mol. Biol. Cell 22, 1274-1289.
  7. Kasahara, K., Goto, H., Enomoto, M., Tomono, Y., Kiyono, T. and Inagaki, M. (2010). 14-3-3γ mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage. EMBO J. 29, 2802-2812.
  8. Enomoto, M., Goto, H., Tomono, Y., Kasahara, K., Tsujimura, K., Kiyono, T. and Inagaki, M. (2009). Novel positive feedback loop between Cdk1 and Chk1 in the nucleus during the G2/M transition. J. Biol. Chem. 284, 34223-34230.
  9. Sugimoto, M., Inoko, A., Shiromizu, T., Nakayama, M., Zou, P., Yonemura, S., Hayashi, Y., Izawa, I., Sasoh, M., Uji, Y., Kaibuchi, K., Kiyono, T. and Inagaki, M. (2008). The keratin-binding protein Albatross regulates polarization of epithelial cells. J. Cell Biol. 183, 19-28.
  10. Toyo-oka, K., Mori, D., Yano, Y., Shiota, M., Iwao, H., Goto, H., Inagaki, M., Hiraiwa, N., Muramatsu, M., Wynshaw-Boris, A., Yoshiki, A. and Hirotsune, S. (2008). Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation. J. Cell Biol. 180, 1133-1147.
  11. Goto, H. and Inagaki, M. (2007). Production of a site- and phosphorylation state-specific antibody. Nat. Protoc. 2, 2574-2581.
  12. Goto, H., Kiyono, T., Tomono, Y., Kawajiri, A., Urano, T., Furukawa, K., Nigg, E.A. and Inagaki, M. (2006). Complex formation of Plk1 and INCENP required for metaphase-anaphase transition. Nat. Cell Biol. 8, 180-187.

A 02-2研究分担者: 五島 直樹(産業技術総合研究所)

  1. Minami, S., Nagashio, R., Ueda, J., Matsumo, K., Goshima, N., Hattori, M., Hachimura, K., Iwamura, M., and Yuichi Sato, Y.(2014). Detection of tumor-associated antigens in culture supernatants using autoantibodies in sera from patients with bladder cancer. Biomedical Research (Tokyo) 35 (1), 25-35,
  2. Tamaoki, N., Takahashi, K., Aoki, H., Iida, K., Kawaguchi, T., Inden, M., Chosa, N., Ishisaki, A., Kunisada, T., Shibata, T., Goshima, N., and Tezuka, K. (2014) The homeobox gene DLX4 promotes generation of human induced pluripotent stem cells. Scientific Reports, Dec 4;4:7283. doi: 10.1038/srep07283.
  3. Kasahara, K., Kawakami, Y., Kiyono, T., Yonemura, S., Kawamura, Y., Era, S., Matsuzaki, F., Goshima, N., Inagaki, M. (2014) Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension. Nature communications 5, Article number:5081 doi:10.1038/ncomms6081
  4. Tetsuro Hirose and Naoki Goshima: Genome-wide co-localization screening of nuclear body components using a fluorescently tagged FLJ cDNA clone library. Methods in Molecular Biology (in press) (2014)
  5. Naoto Muraoka, Hiroyuki Yamakawa, Kazutaka Miyamoto, Sadahiro, T., Umei, T., Isomi, M., Nakashima, H., Akiyama, M., Wada, R., Inagawa, K., Nishiyama, T., Kaneda, R., Fukuda, T., Takeda, S., Tohyama, S., Hashimoto, H., Kawamura, Y., Goshima, N., Aeba, R., Yamagishi, H., Fukuda, K., Ieda, M. (2014) MiR-133 Promotes Cardiac Reprogramming by Directly Repressing Snai1 and Silencing Fibroblast Signatures. EMBO J. 33(14), 1565-1581.
  6. Doi, A., Ishikawa, K., Shibata, N., Ito, E., Fujimoto, J., Yamamoto, M., Shiga, H., Mochizuki, H., Kawamura, Y., Goshima, N., Semba, K., Watanabe, S.(2014) Enhanced expression of retinoic acid receptor alpha (RARA) induces epithelial-to-mesenchymal transition and disruption of mammary acinar structures. Mol Oncol.: S1574-7891(14)00218-X. doi: 10.1016/j.molonc.2014.09.005.
  7. Ishida, A., Tsumura, K., Oue, M., Takenaka, Y., Shigeri, Y., Goshima, N., Ishihara, Y., Hirano, T., Baba, H., Sueyoshi, N., Kameshita, I., and Yamazaki, T. (2013) An active C-terminally truncated form of Ca2+/calmodulin-dependent protein kinase phosphatase-N (CaMKP-N/PPM1E). BioMed Research International ID 134813, doi:10.1155/2013/134813.
  8. Yugawa, T., Nishino, K., Ohno, S., Nakahara, T., Fujita, M., Goshima, N., Umezawa, A., and Kiyono, T. (2013) Non-canonical NOTCH signaling limits self-renewal of human epithelial and iPS cells through ROCK activation. Mol Cell Biol. 33 (22), 4434 – 4447.
  9. Yamamoto, T., Nakayama, K., Hirano, H., Tomonaga, T., Ishihama, Y., Yamada, T., Kondo, T., Kodera, Y., Sato, Y., Araki, N., Mamitsuka, H. and Goshima, N. (2013). Integrated View of the Human Chromosome X-centric Proteome Project. J. Proteome Res. 12, 58-61.
  10. Okita, K., Yamakawa, T., Matsumura, Y., Sato, Y., Amano, N., Watanabe, A., Goshima, N. and Yamanaka, S. (2013). An Efficient Non-viral Method to Generate Integration-Free Human iPS Cells from Cord Blood and Peripheral Blood Cells. Stem Cells 31(3), 458-66.
  11. Naganuma, T., Nakagawa, S., Tanigawa, A., Yasnory F Sasaki, Goshima, N. and Hirose, T. (2012). Alternative 3’-end processing of long noncoding RNA initiates construction of nuclear paraspeckles. EMBO J. 31, 4020-4034.
  12. Saito, M., Kato, Y., Ito, E., Fujimoto, J., Ishikawa, K., Doi, A., Kumazawa, K., Matsui, A., Takebe, S., Ishida, T., Azuma, S., Mochizuki, H., Kawamura, Y. Yanagisawa, Y., Honma, R., Imai, J., Ohbayashi, H., Goshima, N., Semba, S., Watanabe, S. (2012) Expression screening of 17q12-21 amplicon reveals GRB7 as an ERBB2-dependent oncogene. FEBS Letters 586(12), 1708-1714.
  13. Maekawa, M., Yamaguchi, K., Nakamura, T., Shibukawa, R., Kodanaka, I., Ichisaka, T., Kawamura, Y., Mochizuki, H., Goshima,N. and Yamanaka S. (2011). Promotion of Direct Reprogramming by Maternal Transcription Factor Glis1. Nature 474, 225-229.
  14. Miyamoto, K., Iwadate, M., Yanagisawa, Y., Ito, E., Imai, J., Yamamoto, M., Sawada, N., Saito, M., Suzuki, S., Nakamura, I., Ohki, S., Saze, Z., Kogur,e M., Gotoh, M., Omicronbara, K., Ohira, H., Tasaki, K., Abe, M., Goshima, N., Watanabe, S., Waguri, S., Takenoshita, S. (2011). Cathepsin L is highly expressed in gastrointestinal stromal tumors. Int J Oncol. 39(5), 1109-15.
  15. Matsuyama, M., Goto, H., Kasahara, K., Kawakami, Y., Nakanishi, M., Kiyono, T., Goshima, N., Inagaki,M. (2011). Nuclear Chk1 prevents premature mitotic entry. J. Cell Sci. 124, 2113-2119.
  16. Takeda, H., Kawamura, Y., Miura, A., Mori, M., Wakamatsu, A., Yamamoto, J., Isogai, T., Matsumoto, M., Nakayama, K.I., Natsume, T., Nomura, N. and Goshima, N. (2010). Comparative analysis of human Src-family kinase substrate specificity in vitro. J. Proteome Res. 9, 5982-5993.
  17. Maruyama, Y., Wakamatsu, A., Kawamura, Y., Kimura, K., Yamamoto, J., Nishikawa, T., Kisu, Y., Sugano, S., Goshima, N., Isogai, T., Nomura, N. (2009). Human Gene and Protein Database (HGPD): a novel database presenting a large quantity of experiment-based results in human proteomics. Nucleic Acids Res. 37 (Database issue), D762-766.
  18. Goshima, N., Kawamura, Y., Fukumoto, A., Miura, A., Honma, R., (以下49名省略) and Nomura, N. (2008). Human protein factory for converting the transcriptome into an in vitro-expressed proteome. Nature methods. 5, 1011-1017.

A 03-1研究代表者: 松崎 文雄(理化学研究所 発生・再生科学総合研究センター)

  1. Kasahara K, Kawakami Y, Kiyono T, Yonemura S, Kawamura Y, Era S, Matsuzaki F, Goshima N, Inagaki M. Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension. Nat Commun. 2014 Oct 1;5:5081. doi: 10.1038/ncomms6081. (2014)
  2. Mora-Bermúdez F, Matsuzaki F and Huttner WB. Specific polar subpopulations of astral microtubules control spindle orientation and symmetric neural stem cell division. Elife. Jul 4:e02875. doi: 10.7554/eLife.02875 (2014).
  3. Pilz GA, Shitamukai A, Reillo I, Pacary E, Schwausch J, Stahl R, Ninkovic J, Snippert HJ, Clevers H, Godinho L, Guillemot F, Borrell V, Matsuzaki F, Götz M. Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type. Nat Commun. 4:2125. doi: 10.1038/ncomms3125 (2013)
  4. Matsuzaki F, and Shitamukai A. Cell division modes and cleavage planes of neural progenitors during mammalian cortical development. Cold Spring Harb Perspect Biol. Mammalian Develop. Doi 10.1101/cshperspect.a015719 (2013).
  5. Iwano T, Masuda A, Kiyonari H, Enomoto H, and Matsuzaki F. Prox1 postmitotically defines dentate gyrus cells by specifying the granule cell identity over the CA3 pyramidal cell fate in the hippocampus. Development 139, 3051-62 (2012)
  6. Shitamukai A, and Matsuzaki F. Control of asymmetric cell division of mammalian neural progenitors. Dev Growth Differ. 54, 277-286 (2012).
  7. Yoshiura S, Ohta N, and Matsuzaki F. Tre1 GPCR signaling orients stem cell divisions in the Drosophila central nervous system. Dev. Cell 22, 1-13 (2012).
  8. Kelava I, Reillo I, Murayama AY, Kalinka AT, Stenzel D, Tomancak P, Matsuzaki F, Lebrand C, Sasaki E, Schwamborn JC, Okano H, Huttner WB, Borrell V. Abundant Occurrence of Basal Radial Glia in the Subventricular Zone of Embryonic Neocortex of a Lissencephalic Primate, the Common Marmoset Callithrix jacchus. Cereb Cortex. 22, 469-481 (2012).
  9. Konno D, Iwashita M, Satoh Y, Momiyama A, Abe T, Kiyonari H, Matsuzaki F. (2012). The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex. PLoS One. 7(10):e46577. doi: 10.1371.
  10. Iwano T, Masuda A, Kiyonari H, Enomoto H, and Matsuzaki F. (2012). Prox1 postmitotically defines dentate gyrus cells by specifying the granule cell identity over the CA3 pyramidal cell fate in the hippocampus. Development 139, 3051-62.
  11. Shitamukai A, and Matsuzaki F. (2012). Control of asymmetric cell division of mammalian neural progenitors. Dev Growth Differ. 54, 277-286.
  12. Yoshiura S, Ohta N, and Matsuzaki F. (2012). Tre1 GPCR signaling orients stem cell divisions in the Drosophila central nervous system. Dev. Cell 22, 1-13.
  13. Kosodo Y, Suetsugu T, Suda M, Mimori-Kiyosue Y, Toida K, Baba SA, Kimura A, and Matsuzaki F. Regulation of Interkinetic Nuclear Migration by Cell Cycle-Coupled Active and Passive Mechanisms in the Developing Brain. EMBO J. 30, 1690-1704 (2011).
  14. Shitamukai A, Konno D, and Matsuzaki F. Oblique radial glial divisions in the developing mouse neocortex induce self-renewing progenitors outside the germinal zone that resemble primate outer-subventricular zone progenitors. J Neurosci. 31, 3683–3695 (2011).
  15. Wang C, Li S, Januschke J, Rossi F, Izumi Y, Garcia-Alvarez G, Gwee SS, Soon SB, Sidhu HK, Yu F, Matsuzaki F, Gonzalez C, and Wang H. (2011). An Ana2/Ctp/Mud Complex Regulates Spindle Orientation in Drosophila Neuroblasts. Dev Cell 21, 520-533.
  16. Kosodo Y, Suetsugu T, Suda M, Mimori-Kiyosue Y, Toida K, Baba SA, Kimura A, and Matsuzaki F. (2011). Regulation of Interkinetic Nuclear Migration by Cell Cycle-Coupled Active and Passive Mechanisms in the Developing Brain. EMBO J. 30, 1690-1704.
  17. Shitamukai A, Konno D, and Matsuzaki F. (2011). Oblique radial glial divisions in the developing mouse neocortex induce self-renewing progenitors outside the germinal zone that resemble primate outer-subventricular zone progenitors. J Neurosci. 31, 3683-3695.
  18. Konno D, Shioi G, Shitamukai A, Mori A, Kiyonari H, Miyata T, Matsuzaki F. Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis. (2008). Nat Cell Biol. 100, 93-101. published online: 16 December 2007; doi:10.1038/ncb1673
  19. Izumi, Y., Ohta, N., Hisata K., Raabe, T. and Matsuzaki, F. (2006). Drosophila Pins-binding protein Mud regulates spindle-polarity coupling and centrosome organization. Nat. Cell Biol. 8, 586-593.

A 03-2研究代表者: 広常 真治(大阪市立大学大学院医学研究科)

  1. Xie Y, Juschke C, Esk C, Hirotsune S, Knoblich JA. (2013). The Phosphatase PP4c Controls Spindle Orientation to Maintain Proliferative Symmetric Divisions in the Developing Neocortex. Neuron S0896-6273(13)00447-9.
  2. Yamada, M., Kumamoto, K., Mikuni S., Arai Y., Kinjo M., Nagai T., Tsukasaki Y., M. Watanabe T., Toba S. and Hirotsune S.. (2013). Rab6a releases LIS1 from a dynein idling complex and activates dynein for retrograde movement. Nature Communication 4:2033.
  3. Sebe, J. Y., Bershteyn, M., Hirotsune S, Wynshaw-Boris, A., and Baraban, S. C. (2013). ALLN rescues an in vitro excitatory synaptic transmission deficit in Lis1 mutant mice. J Neurophysiol 109, 429-436.
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