研究目標

 生命活動を演劇に例えると、ゲノムには演劇の脚本が書き込まれており、個々の遺伝子は役者にあたる蛋白質の役柄を決めていると考えてよいでしょう。しかし、個々の役者の性質が決まっただけでは演劇は成り立ちません。それぞれの役者が互いにどうかかわり合い、舞台である細胞でいつどこで何を演じるのかが重要です。鈴木研では、このような蛋白質の細胞内動態や相互の位置関係が細胞の機能発現にどのような意味を持つのか、またそれらがどのような遺伝子制御を受けているのか、といった側面を様々な生命活動の場面で明らかにすることを目標にしています。現在以下のテーマについて研究を進めています。



現在進行中の研究
1) 味覚系神経回路の構造と機能の研究

 

研究目標

 研究は山あり谷ありで、時には思ったような結果が出ずにがっかりすることもあります。しかしそんな時、へこたれずに結果について考え直してみると思いがけない新発見があるものです。そのような前向きな姿勢を身につけるには、研究室でメンバー同士がそれぞれの研究について議論するトレーニングが大切と考えます。鈴木研では週1回各人の研究の進行状況を発表しあい、忌憚の無い意見を聞くミーティングがあるほか、遺伝研内で行なわれている勉強会やセミナーに参加しています。
このような機会を通して、研究者としてコミュニケーションする能力と柔軟な精神力を養って欲しいと考えています。

研究目標

発表論文( 20042016)

1.  Tamori, Y., Suzuki, E. & Deng, W.-M. (2016) Epithelial Tumors Originate in Tumor Hotspots, a Tissue-Intrinsic Microenvironment, PLoS Biol. 14, e1002537.

2.  Nakayama, M., Suzuki, E., Tsunoda, S. i. & Hama, C. (2016) The Matrix Proteins Hasp and Hig Exhibit Segregated Distribution within Synaptic Clefts and Play Distinct Roles in Synaptogenesis, Journal of Neuroscience. 36, 590-606.

3.  Ando, K., Hearn, S., Suzuki, E., Maruko-Otake, A., Sekiya, M. & Iijima, K. (2016) Electron Microscopy of the Brains of Drosophila Models of Alzheimer’s Diseases in Transmission Electron Microscopy Methods for Understanding the Brain (Bockstaele, E. J. V., ed) pp. 105-123, Springer International Publishing AG.

4.  Sugie, A., Hakeda-Suzuki, S., Suzuki, E., Silies, M., Shimozono, M., Möhl, C., Suzuki, T. & Tavosanis, G. (2015) Molecular Remodeling of the Presynaptic Active Zone of Drosophila Photoreceptors via Activity-Dependent Feedback, Neuron. 86, 711-725.

5.  Okumura, T., Sasamura, T., Inatomi, M., Hozumi, S., Nakamura, M., Hatori, R., Taniguchi, K., Nakazawa, N., Suzuki, E., Maeda, R., Yamakawa, T. & Matsuno, K. (2015) Class I Myosins Have Overlapping and Specialized Functions in Left-Right Asymmetric Development in Drosophila, Genetics. 199, 1183-1199.

6.  Tamori, Y. & Deng, W. M. (2014) Compensatory cellular hypertrophy: the other strategy for tissue homeostasis, Trends Cell Biol. 24, 230-7.

7.  Mauthner, S. E., Hwang, R. Y., Lewis, A. H., Xiao, Q., Tsubouchi, A., Wang, Y., Honjo, K., Skene, J. H., Grandl, J. & Tracey, W. D., Jr. (2014) Balboa binds to pickpocket in vivo and is required for mechanical nociception in Drosophila larvae, Curr Biol. 24, 2920-5.

8.  Matsuoka, S., Gupta, S., Suzuki, E., Hiromi, Y. & Asaoka, M. (2014) gone early, a Novel Germline Factor, Ensures the Proper Size of the Stem Cell Precursor Pool in the Drosophila Ovary, PLoS ONE. 9, e113423.

9.  Jia, D., Tamori, Y., Pyrowolakis, G. & Deng, W. M. (2014) Regulation of broad by the Notch pathway affects timing of follicle cell development, Dev Biol. 392, 52-61.

10.  Homma, M., Nagashima, S., Fukuda, T., Yanagi, S., Miyakawa, H., Suzuki, E. & Morimoto, T. (2014) Downregulation of Centaurin gamma1A increases synaptic transmission at Drosophila larval neuromuscular junctions, The European journal of neuroscience. 40, 3158-70.

11.  鈴木えみ子 & 来栖光彦 (2013) 神経分化に伴うN-カドヘリンの細胞内分布と機能の変化, 生体の科学. 64, 249-253.

12.  Sasaki, O., Yoshizumi, T., Kuboyama, M., Ishihara, T., Suzuki, E., Kawabata, S. I. & Koshiba, T. (2013) A structural perspective of the MAVS-regulatory mechanism on the mitochondrial outer membrane using bioluminescence resonance energy transfer, Biochimica et biophysica acta. 1833, 1017-1027.

13.  Tanaka, N., Suzuki, E., Louis, D., Ejima, A. & Stopfer, M. (2012) Dye fills reveal additional olfactory tracts in the protocerebrum of wild-type Drosophila., J Comp Neurol. 520, 4131-4140.

14.  Suzuki, E., Masai, I. & Inoue, H. (2012) Phosphoinositide Metabolism in Drosophila Phototransduction: A Coffee Break Discussion Leads to 30 Years of History, J Neurogenet. 26, 34-42.

15.  Kurusu, M., Katsuki, T., Zinn, K. & Suzuki, E. (2012) Developmental changes in expression, subcellular distribution, and function of Drosophila N-cadherin, guided by a cell-intrinsic program during neuronal differentiation, Dev Biol. 366, 204-217.

16.  Iijima-Ando, K., Sekiya, M., Maruko-Otake, A., Ohtake, Y., Suzuki, E., Lu, B. & Iijima, K. M. (2012) Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease–Related Tau Phosphorylation Via PAR-1, PLoS Genetics. 8, e1002918.

17.  Yamakawa, T., Yamada, K., Sasamura, T., Nakazawa, N., Kanai, M., Suzuki, E., Fortini, M. E. & Matsuno, K. (2011) Deficient Notch signaling associated with neurogenic pecanex is compensated for by the unfolded protein response in Drosophila, Development. 139, 558-567.

18.  Sakaidani, Y., Nomura, T., Matsuura, A., Ito, M., Suzuki, E., Murakami, K., Nadano, D., Matsuda, T., Furukawa, K. & Okajima, T. (2011) O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions, Nature communications. 2, 583-592.

19.  Nakayama, M., Sato, H., Okuda, T., Fujisawa, N., Kono, N., Arai, H., Suzuki, E., Umeda, M., Ishikawa, H. O. & Matsuno, K. (2011) Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes, PLoS ONE. 6, e22984.

20.  Mochizuki, H., Toda, H., Ando, M., Kurusu, M., Tomoda, T. & Furukubo-Tokunaga, K. (2011) Unc-51/ATG1 controls axonal and dendritic development via kinesin-mediated vesicle transport in the Drosophila brain, PLoS ONE. 6, e19632.

21.  Yasunaga, K., Kanamori, T., Morikawa, R., Suzuki, E. & Emoto, K. (2010) Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase-mediated modification of the basement membranes, Developmental cell. 18, 621-32.

22.  Midorikawa, R., Yamamoto-Hino, M., Awano, W., Hinohara, Y., Suzuki, E., Ueda, R. & Goto, S. (2010) Autophagy-dependent rhodopsin degradation prevents retinal degeneration in Drosophila, J Neurosci. 30, 10703-19.

23.  Sone, M., Uchida, A., Komatsu, A., Suzuki, E., Ibuki, I., Asada, M., Shiwaku, H., Tamura, T., Hoshino, M., Okazawa, H. & Nabeshima, Y. (2009) Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening, PLoS One. 4, e4466.

24.  Kurusu, M., Maruyama, Y., Adachi, Y., Okabe, M., Suzuki, E. & Furukubo-Tokunaga, K. (2009) A conserved nuclear receptor, Tailless, is required for efficient proliferation and prolonged maintenance of mushroom body progenitors in the Drosophila brain, Dev Biol. 326, 224-36.

25.  Hong, W., Zhu, H., Potter, C. J., Barsh, G., Kurusu, M., Zinn, K. & Luo, L. (2009) Leucine-rich repeat transmembrane proteins instruct discrete dendrite targeting in an olfactory map, Nat Neurosci. 12, 1542-50.

26.  Furukubo-Tokunaga, K., Adachi, Y., Kurusu, M. & Walldorf, U. (2009) Brain patterning defects caused by mutations of the twin of eyeless gene in Drosophila melanogaster, Fly (Austin). 3, 263-9.

27.  Toda, H., Mochizuki, H., Flores, R., 3rd, Josowitz, R., Krasieva, T. B., Lamorte, V. J., Suzuki, E., Gindhart, J. G., Furukubo-Tokunaga, K. & Tomoda, T. (2008) UNC-51/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly, Genes & development. 22, 3292-307.

28.  Nishiwaki, Y., Komori, A., Sagara, H., Suzuki, E., Manabe, T., Hosoya, T., Nojima, Y., Wada, H., Tanaka, H., Okamoto, H. & Masai, I. (2008) Mutation of cGMP phosphodiesterase 6alpha'-subunit gene causes progressive degeneration of cone photoreceptors in zebrafish, Mech Dev. 125, 932-46.

29.  Kurusu, M. & Zinn, K. (2008) Receptor tyrosine phosphatases regulate birth order-dependent axonal fasciculation and midline repulsion during development of the Drosophila mushroom body, Mol Cell Neurosci. 38, 53-65.

30.  Kurusu, M., Cording, A., Taniguchi, M., Menon, K., Suzuki, E. & Zinn, K. (2008) A screen of cell-surface molecules identifies leucine-rich repeat proteins as key mediators of synaptic target selection, Neuron. 59, 972-85.

31.  Hori, T., Amano, M., Suzuki, A., Backer, C. B., Welburn, J. P., Dong, Y., McEwen, B. F., Shang, W. H., Suzuki, E., Okawa, K., Cheeseman, I. M. & Fukagawa, T. (2008) CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore, Cell. 135, 1039-52.

32.  Tokai-Nishizumi, N., Ohsugi, M., Suzuki, E. & Yamamoto, T. (2005) The chromokinesin Kid is required for maintenance of proper metaphase spindle size, Mol Biol Cell. 16, 5455-63.

33.  Orihara-Ono, M., Suzuki, E., Saito, M., Yoda, Y., Aigaki, T. & Hama, C. (2005) The slender lobes gene, identified by retarded mushroom body development, is required for proper nucleolar organization in Drosophila, Dev Biol. 281, 121-33.

34.  鈴木えみ子 (2004) 標的認識分子から見たシナプス形成機構, 細胞. 36, 66-69.

35.  Xu, H., Lee, S. J., Suzuki, E., Dugan, K. D., Stoddard, A., Li, H. S., Chodosh, L. A. & Montell, C. (2004) A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen, Embo J. 23, 811-22.

36.  Kohyama-Koganeya, A., Sasamura, T., Oshima, E., Suzuki, E., Nishihara, S., Ueda, R. & Hirabayashi, Y. (2004) Drosophila glucosylceramide synthase: a negative regulator of cell death mediated by proapoptotic factors, J Biol Chem. 279, 35995-6002.