Neurons in the same functional class are often organized in characteristic spatial patterns throughout the nervous system. In many sensory circuits, for example, a complete and non-redundant representation of sensory information is attained by a tiling tiling arrangement of the dendrites, such that the dendritic arbors of the same cell type show little or no overlap. Here we show that the TOR (Target of Rapamycin) kinase signaling plays a crucial role in regulation of the dendritic tiling of Drosophila sensory neurons. Our genetic and biochemical studies reveal that TOR kinase controls complementary aspects of dendrite development through two distinct complexes: TORC1 for promoting dendritic growth/branching and TORC2 for limiting dendritic growth/branching. We thus propose that the spatio-temporal cross-talking between the two TOR complexes contributes to ensure proper spacing of dendritic fields of sensory neurons.
　The results of this research were published on line in EMBO Journal on October 29th.

	The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signaling pathway.
	Makiko Koike-Kumagai, Kei-ichiro Yasunaga, Rei Morikawa, Takahiro Kanamori, and Kazuo Emoto.
	EMBO Journal doi:10.1038/emboj.2009.312

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Neural Morphogenesis Laboratory,Emoto Laboratory