Laboratory of Mutagenesis,
National Institute of Genetics, JAPAN
Yata 1111, Mishima-city, Sizuoka-pref.
Post-translational modifications and its roles in the integrated chromosomal functions.
The ubiquitin system, post-translationally linking ubiquitin to a vast range of proteins, contributes to a selective proteolysis in eukaryotic cells. Ubiquitin, however, together with other post-translational modification systems, has been expected to play roles other than protein degradation. On the other hand, the chromosomal functions like replication, separation, damage repair, recombination and epigenetic controls and so on, have been revealed owing to the post-translational modification systems. Based on our past achievements in ubiquitin research, we pursue the roles of post-translational modifications, especially by ubiquitin system, in the maintenance of chromosomal integrity, creating new paradigm in the both fields. For this, using fission yeast, we are carrying the following programs.
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National Institute of Genetics, Japan