Actin mutations that induce heat-shock response
アクチン突然変異による熱ショック反応の誘導

Hiromi, Y. and Hotta, Y. (1985). Actin gene mutations in Drosophila; heat shock activation in the indirect flight muscles. EMBO J. 4, 1681-1687. abstract

Hiromi, Y., Okamoto, H., Gehring, W. J. and Hotta, Y. (1986). Germline transformation with Drosophila mutant actin genes induces constitutive expression of heat shock genes. Cell 44, 293-301 abstract

Okamoto, H., Hiromi, Y., Ishikawa, E., Yamada, T., Isoda, K., Maekawa, H. and Hotta, Y. (1986). Molecular characterization of mutant actin genes which induce heat shock proteins in Drosophila flight muscles. EMBO J. 5, 589-596. abstract

Regulation of fushi tarazu expression
fushi tarazu遺伝子の発現調節

Hiromi, Y., Kuroiwa, A. and Gehring, W. J. (1985). Control elements of the Drosophila segmentation gene fushi tarazu. Cell 43, 603-613. abstract

Hiromi, Y. and Gehring, W. J. (1987). Regulation and function of the Drosophila segmentation gene fushi tarazu. Cell 50, 963-974. abstract

Mlodzik, M., De Montrion, C., Hiromi, Y., Krause, H. M., and Gehring, W. J.(1987). The influence on the blastoderm fate map of maternal-effect genes that affect the anterior-posterior pattern in Drosophila. Genes Dev. 1, 603-614. Not in Medline

Dorso-ventral patterning of the embryo
胚背腹軸決定

Roth, S., Hiromi, Y., Godt, D. and Nusslein-Volhard, C. (1991). cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos. Development 112, 371-388. abstract

Geisler, R., Bergman, A., Hiromi, Y., and Nusslein-Volhard, C. (1992). cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IkB gene family of vertebrates. Cell 71, 613-621. abstract

Cell fate determination in the nervous system
神経細胞の運命決定

Doe, C. Q., Hiromi, Y., Gehring, W. J. and Goodman, C. S. (1988). Expression and function of the segmentation gene fushi tarazu during Drosophila neurogenesis. Science 239, 170-175. abstract

Jacobs, J. R., Hiromi, Y., Patel, N.H. and Goodman, C. S. (1989). Lineage, migration and morphogenesis of longitudinal glia in the Drosophila CNS as revealed by a molecular lineage marker. Neuron 2, 1625-1631. abstract

Mlodzik, M., Hiromi, Y., Weber, U., Goodman, C.S. and Rubin, G.M. (1990). The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates. Cell 60, 211-224. abstract

Mlodzik, M., Hiromi, Y., Goodman, C. S., and Rubin, G. M. (1992). The presumptive R7 cell of the developing Drosophila eye receives positional information independent of sevenless, boss and sina. Mech. Dev. 37, 37-42. abstract

Hiromi, Y., Mlodzik, M., West, S. R., Rubin, G. M., and Goodman, C. S. (1993). Ectopic expression of seven-up causes cell fate changes during ommatidial assembly. Development 118, 1123-1135. abstract

Kramer, S., West, S. R. and Hiromi, Y. (1995). Cell fate control in the Drosophila retina by the orphan receptor seven-up: its role in the decisions mediated by the ras signaling pathway. Development 121, 1361-1372. abstract

Publication since 1996
1996年以降の論文

Bush, A., Hiromi, Y. and Cole, M. D. (1996). biparous: a novel bHLH gene expressed in neuronal and glial precursors in Drosophila. Dev. Biol. 180, 759-772. abstract

Butler, S. J., Ray, S. and Hiromi, Y. (1997). klingon, a novel member of the Drosophila Immunoglobulin superfamily, is required for the development of the R7 neuron. Development 124, 781-792. abstract

Ito, K., Awano, W., Suzuki, K., Hiromi, Y., and Yamamoto, D. (1997). The Drosophila mushroom body is a quadruple structure of clonal units each of which contains almost identical set of neurons and glial cells. Development 124, 761-771. abstract

Hacohen, N., Kramer, S., Sutherland, D., Hiromi, Y. and Krasnow, M. A. (1998). sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Cell 92, 253-263. abstract

Kramer, S., Okabe, M., Hacohen, N., Krasnow, M. A., and Hiromi, Y. (1999). Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila. Development 126, 2515-2525. abstract

Hiramoto, M., Hiromi, Y., Giniger, E. and Hotta, Y. (2000). A Drosophila Netrin receptor Frazzled guides axons by controlling Netrin distribution. Nature 406, 886-889. abstract

Okabe, M., Imai, T., Kurusu, M., Hiromi, Y. and Okano, H. (2001). Translational repression determines a neuronal potential in Drosophila asymmetric cell division. Nature 411, 94-98. abstract

Umesono Y, Hiromi Y, Hotta Y. (2002). Context-dependent utilization of Notch activity in Drosophila glial determination. Development 129, 2391-2399. abstract

Liu QX, Jindra M, Ueda H, Hiromi Y, Hirose S. (2003). Drosophila MBF1 is a co-activator for Tracheae Defective and contributes to the formation of tracheal and nervous systems. Development 130, 719-728. abstract

Yuasa, Y., Okabe, M., Yoshikawa, S., Tabuchi, K., Xiong, W.C., Hiromi, Y. and Okano, H. (2003). Drosophila homeodomain protein REPO controls glial differentiation by cooperating with ETS and BTB transcription factors. Development 130, 2419-2428. abstract

Yamada, T., Okabe, M., and Hiromi, Y. (2003). EDL/MAE regulates EGF-mediated induction by antagonizing Ets transcription factor Pointed. Development 130, 4085-4096. abstract

Niwa, N., Hiromi, Y., and Okabe, M. (2004). A conserved developmental program for sensory organ formation in Drosophila melanogaster. Nature Genetics 36, 293-297. abstract

Jindra, M., Gaziova, I., Uhlirova, M., Okabe, M., Hiromi, Y. and Hirose, S. (2004). Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in Drosophila. EMBO J. 23, 3538-3547. abstract

Kanai, M. I., Okabe, M. and Hiromi, Y. (2005). seven-up controls switching of transcription factors that specify identities of Drosophila neuroblasts. Developmental Cell 8, 203-213. abstract

Iwanami, M. Hiromi, Y. and Okabe, M. (2005). Cell-type specific utilization of multiple negative feedback loops generates developmental constancy. Genes Cells 10, 743-752. abstract

Hiramoto, M. and Hiromi, Y. (2006). ROBO licenses axon crossing of segmental boundaries by suppressing responsiveness to relocalized Netrin. Nature Neuroscience 9, 58-66. abstract

Kondo, S., Senoo-Matsuda, N., Hiromi, Y. and Miura, M. (2006). DRONC coordinates cell death and compensatory proliferation. Mol. Cell. Biol. 26, 7258-7268. abstract

Williams, D. W., Kondo, S., Krzyzanowska, A., Hiromi, Y. and Truman, J. W. (2006). Local caspase activity directs engulfment of dendrites during pruning. Nature Neuroscience 9, 1234-1236. abstract

Matsuno M., Kose H., Okabe M., Hiromi Y. (2007). TFIIH controls developmentally-regulated cell cycle progression as a holocomplex. Genes Cells 12,1289-300. abstract

Suto F., Tsuboi M., Kamiya H., Mizuno H., Kiyama Y., Komai S., Shimizu M., Sanbo M., Yagi T., Hiromi Y., Chedotal A., Mitchell K. J., Manabe T. and Fujisawa H. (2007). Interactions between Plexin-A2, Plexin-A4, and Semaphorin 6A Control Lamina-Restricted Projection of Hippocampal Mossy Fibers. Neuron 53, 535-547. abstract

Liu Q.X., Hiramoto M., Ueda H., Gojobori T., Hiromi Y., Hirose S. (2009). Midline governs axon pathfinding by coordinating expression of two major guidance systems. Genes Dev. 23, 1165-70. abstract

Katsuki T., Ailani D., Hiramoto M., Hiromi Y. (2009). Intra-axonal patterning: intrinsic compartmentalization of the axonal membrane in Drosophila neurons. Neuron, 64, 188-199. abstract

Reviews
総説

広海健，堀田凱樹 (1982). ショウジョウバエ飛翔行動の生化学的解析．遺伝 36, 8-15.

Gehring, W. J. and Hiromi, Y. (1986). Homeotic genes and the homeobox. Ann. Rev. Genet. 20, 147-173.

広海 健 (1988). ショウジョウバエ分節遺伝子 fushi tarazu の機能と調節機構:　 細胞運命を決定する遺伝子. 　実験医学 6, 1196-1204.

広海 健 (1989). ショウジョウバエ神経系形成の遺伝子支配．実験医学 7, 897-904.

広海 健 (1991). ショウジョウバエ体節形成の分子機構． 医科分子生物学　改訂第２版 pp. 256-268.　村松正実　編集．南江堂．

Mlodzik, M. and Hiromi, Y. (1992). Enhancer trap method in Drosophila: its application to neurobiology. In "Gene Expression in Neural Tissues" (Methods in Neurosciences 9), P. M. Conn, ed. pp. 397-414. Academic Press, San Diego.

広海健 (1992). エンハンサートラップ法--原理と応用．新生化学実験口座１４．発生・分?宗ο群 pp.52-63. 日本生化学会編．東京化学同人．

広海 健 (1996). ショウジョウバエ体節形成の分子機構．医科分子生物学　改訂第3版 pp. 301-311. 村松正実・谷口維紹　編集．南江堂．

山田 琢磨, 広海 健 (1996). TO BE OR NOT TO BE-ショウジョウバエ光受容細胞の神経分化経路. 実験医学 14, 1150-1155.

細谷俊彦, 藤岡美輝, Janes, J. B., 広海健 (2000). ショウジョウバエのRunt, Lozengeによる分化制御. 蛋白質 核酸 酵素 45, 7-12.

丹羽尚, 岡部正隆, 広海健 (2002) . 神経系の進化　―遺伝子が語る神経系形成の共通システム―　科学 72, 315-322.

梅園良彦, 広海健 (2002). Notchシグナルと環境因子　-ショウジョウバエを用いた神経性形成機構?硫鮴-　実験医学 20, 1643-1649.

金井誠 広海健 (2006). 神経幹細胞における遺伝子発現プログラムのスイッチング　細胞工学 25, 33-37.

平本正輝, 広海健 (2007). ポスト科学走行仮説 ー 拡散性濃度勾配を使わない軸索パターニング
細胞工学 26, 1147-1152.

勝木健雄, 広海健 (2008). 神経回路形成における構造・機能相関 ー 軸索ガイダンス受容体はなぜ軸索内局在をするのか？蛋白質核酸酵素 53, 537-543.

その他

広海健 (2000)
ハエの名前の付け方 (遺伝学電子博物館)

広海 健 (2004).
縞と縞のあいだ　「一枚の写真館」　細胞工学 23, 1361.　

広海 健 (2005).
この遺伝子・・・だれ？？　人物にちなんだ遺伝子の名前　化学 60, 28-29.