The human brain receives, processes, stores and transmits complex information with great fidelity. The neuronal network that underlies these functions is comprised of an estimated 10¹¹ neurons linked by over 10¹⁴ synaptic connections between two structurally and functionally different neurites, axons and dendrites. Precise patterning of dendrites as well as axons is essential for correct wiring and function of neural circuits. We combine fly genetic, imaging, and biochemical approaches to investigate the interplay between genetic and epigenetic control of neural morphogenesis, and to deduce the functional importance of these regulatory systems in disease etiology. In particular, we focus our researches on the genetic and molecular regulation of dendrite patterning, maintenance, and plasticity in fly PNS neurons.

Emoto, K., Parrish, J. Z., Jan L. Y., and Jan, Y. N. (2006) The tumor suppressor kinase Hippo functions with the NDR kinases Tricornered and Warts to regulate dendritic tiling and maintenance. Nature in press.

Emoto, K., He, Y., Ye, B., Grueber, W.B., Adler, P.N., Jan, L.Y., and Jan, Y.N. (2004) Control of dendritic branching and tiling by the Tricornered-kinase/Furry signaling pathway in Drosophila sensory neurons. Cell 119, 245-256.

Emoto, K. and Umeda, M. (2000) An essential role for a membrane phospholipid in cytokinesis: Regulation of contractile ring disassembly by redistribution of phosphatidylethanolamine. J. Cell Biol. 149, 1215-1224.

Emoto, K., Kuge, O., Nishijima, M., and Umeda, M. (1999) Isolation of a Chinese hamster ovary cell mutant defective in intramitochondrial transport of phosphatidylserine. Proc. Natl. Acad. Sci. USA 96, 12400-12405.

Emoto, K., Kobayashi, T., Yamaji, A., Aizawa, H., Yahara, I., Inoue, K., and Umeda, M. (1996) Redistribution of phosphatidylethanolamine at the cleavage furrow of dividing cells during cytokinesis. Proc. Natl. Acad. Sci. USA 93, 12867-12872.