Dermal morphogenesis controls lateral line patterning during postembryonic development of teleost fish
PRESTO, Japan Science and Technology Agency (JST)
Developmental Biology
Division of Molecular and Developmental Biology
Dermal morphogenesis controls lateral line patterning during postembryonic development of teleost fish.
Hironori Wada, Alain Ghysen, Chie Satou, Shin-ichi Higashijima, Koichi Kawakami, Satoshi Hamaguchi, and Mitsuru Sakaizumi
Developmental Biology 340 ,583-594, 2010.@doi:10.1016/j.ydbio.2010.02.017


@The lateral line system displays highly divergent patterns in adult teleost fish. The mechanisms underlying this variability are poorly understood. Here, we demonstrate that the lateral line mechanoreceptor, the neuromast, gives rise to a series of accessory neuromasts by a serial budding process during postembryonic development in zebrafish. We also show that accessory neuromast formation is highly correlated to the development of underlying dermal structures such as bones and scales. Abnormalities in opercular bone morphogenesis, in endothelin 1-knockdown embryos, are accompanied by stereotypic errors in neuromast budding and positioning, further demonstrating the tight correlation between the patterning of neuromasts and of the underlying dermal bones. In medaka, where scales form between peridermis and opercular bones, the lateral line displays a scale-specific pattern which is never observed in zebrafish. These results strongly suggest a control of postembryonic neuromast patterns by underlying dermal structures. This dermal control may explain some aspects of the evolution of lateral line patterns.


Figure
@ iAjBudding processes of the opercular neuromast in embryos doubly transgenic for cldnb:gfp (expresses GFP in all neuromast cells, green) and atoh1a:dtomato (expresses RFP in hair cells, red).
(B) Schematic representation of the developing lateral line system in the operculum, the scale, and the caudal fin.


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