| rDNA as a DNA damage sensor | ||
| Cellular and Molecular Life Sciences | ||
| Kobayashi Laboratory , Division of Cytogenetics | ||
| Regulation of ribosomal RNA gene copy number and its role in modulating genome integrity and evolutionary adaptability in yeast. Takehiko Kobayashi Cellular and Molecular Life Sciences Published online 05 Jan 2011 DOI: 10.1007/s00018-010-0613-2 The genes encoding ribosomal RNA, so-called rDNA, are the most abundant genes in the eukaryotic genome. They reside in tandem repetitive clusters, in some cases totaling hundreds of copies. Due to their repetitive structure, the rDNA is some of the most fragile sites in the chromosome. We recently found that the repeat number determines sensitivity to DNA damage (Ide et al., 2010, Science ). In addition, rDNA instability is known to induce cellular senescence (Ganley et al., 2009, Mol Cell ). In this review, I am introducing a new aspect of the rDNA as a center of maintenance of genome integrity and discuss its contribution to evolution. This paper was selected the top 2% paper in biology and medicine by Faculty 1000. http://f1000.com/8159964
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