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A model for cell-size-dependent spindle elongation

 Press Release 

Current Biology

Kimura Laboratory, Cell Architecture Laboratory
Cell-Size-Dependent Spindle Elongation in the Caenorhabditis elegans Early Embryo 
Hara Y., Kimura A. 
Current Biology 19 (18), 1549-1554, 2009.   DOI: 10.1016/j.cub.2009.07.050
 
  Cell size is one of the critical parameters controlling the size of intracellular structures. For example, the sizes of the cell nucleus or the metaphase spindle are known to correlate well with the cell size. However, the mechanisms to coordinate the sizes of cell and intracellular structures have been unclear. We focused on the process of spindle elongation. During anaphase, the mitotic spindle elongates and delivers the centrosomes and sister chromatids near the centers of the nascent daughter cells. We quantified the relationship between spindle elongation and cell size in the early embryo of Caenorhabditis elegans and propose possible models for cell-size-dependent spindle elongation. Quantitative measurements revealed that the extent and speed of spindle elongation are correlated with cell size. Simulation analyses revealed that a combination of the constant-pulling model and the force-generator-limited model reproduced the in vivo dynamics of the cell-size-dependent spindle elongation.

 The results of this research were published on line in Current Bilogy on August 14th.